Kruse Cholinergic Drugs Flashcards
What are the direct acting choline ester drugs?
Acetylcholine, Methacholine, Carbachol, Bethanechol, Cevimeline, Pilocarpine
What are the direct acting alkaloid drugs?
Nicotine, Muscarine
What are the two types of indirect acting cholinergic drugs?
Charged and Neutral AchE inhibitors
What are the charged AchE inhibitors?
Edrophonium, Pyridostigmine, Neostigmine, Echothiophate, Ambenonium
What are the neutral AchE inhibitors?
Organophosphates, Physostigmine, Donepezil, Galantamine, Rivastigmine, Tacrine
What is Varenicline used for?
Smoking cessation (nAchR partial agonist)
What are the common side effects of Varenicline?
Nausea, behavioral changes, agitation, depression, suicidal ideations/acts
What are the 3 groups of AchE inhibitors?
Alcohols (reversible), Carbamic acid esters (reversible), Organophosphates (irreversible)
What is the prototypical anti-mAchR drug?
Atropine
What are the common cholinergic antagonist drugs?
Scopolamine, Atropine, Dicyclomine, Hyoscyamine, Ipratropium, Tiotropium, Oxybutynin, Pralidoxime
What drugs are used for Parkinsons disease?
Benztropine, Trihexyphenidyl, Procyclidine
What drug is used for motion sickness?
Scopolamine
Which drug blocks the vagal reflex response during anesthesia?
Atropine
Which drugs are inhaled to treat asthma/COPD?
Ipratropium, Tiotropium
Which drug is most commonly used to treat common traveler’s diarrhea (GI disorders)?
Lomotil (Atropine + diphenoxylate)
