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Zak, Pharmacology Week > Konorev Adrenergic Antagonist Drugs > Flashcards

Konorev Adrenergic Antagonist Drugs Flashcards

1
Q

Which drugs are non-selective alpha antagonists?

A

Phentolamine, Phenoxybenzamine

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2
Q

Which drugs are alpha1 selective antagonists? What is their common suffix?

A

Prazosin, Terazosin, Tamsulosin, Doxazosin, Alfuzosin, Silodosin; -osin

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3
Q

What are the major cardiovascular effects of alpha antagonistic drugs?

A

Decreased PVR and BP, postural HTN, reflex tachycardia

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4
Q

What are the major genitourinary effects of alpha antagonistic drugs?

A

SM relaxation in prostate, decreases urine flow resistance

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5
Q

What are the major eye effects of alpha antagonistic drugs?

A

Pupillary dilator m. relaxation (miosis)

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6
Q

What are the common clinical uses of alpha antagonists?

A

Pheochromocytoma, Chronic HTN, BPH, ED

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7
Q

Which two alpha antagonists have the greatest selectivity for alpha1A receptors which are mostly found on the prostate?

A

Tamsulosin, Silodosin

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8
Q

Which drugs are mixed adrenergic antagonists?

A

Labetalol, Carvedilol

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9
Q

Which drugs are non-selective ß blockers/antagonists?

A

Propranolol, Pindolol, Nadolol, Penbutolol

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10
Q

Which drugs are ß1 selective ß blockers/antagonists?

A

Metoprolol, Betaxolol, Acebutolol, Atenolol

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11
Q

What is the common suffix of all ß blockers?

A

-olol

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12
Q

Which ß blockers are full antagonists?

A

Atenolol, Nadolol, Propranolol, Betaxolol

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13
Q

Which ß blockers are partial agonists?

A

Acebutolol, Labetalol, Penbutolol, Pindolol

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14
Q

Which ß blockers are inverse agonists?

A

Carvedilol, Metoprolol

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15
Q

What are the major heart effects of ß-blockers?

A

Negative inotropic/chronotropic effects

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16
Q

What are the major blood vessel effects of ß-blockers?

A

Initial rise in PVR followed by decrease in PVR with chronic use

17
Q

What are the major RAAS effects of ß-blockers?

A

Inhibition of renin release

18
Q

What are the major respiratory effects of ß-blockers?

A

Increased airway resistance

19
Q

What are the major eye effects of ß-blockers?

A

Reduce aqueous humor production (reduce intraocular pressure)

20
Q

What are the major metabolic effects of ß-blockers?

A

Inhibit lipolysis, increase VLDL, decrease HDL, inhibit gluconeogenesis/glycogenolysis

21
Q

What are the major clinical uses for ß-blockers?

A

Angina pectoris, HTN, MI, Cardiac arrhythmias, Heart failure, Glaucoma, Hyperthyroidism

Zak, Pharmacology Week (13 decks)

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