Konorev Adrenergic Antagonist Drugs

Question 1

Which drugs are non-selective alpha antagonists?

Answer 1

Phentolamine, Phenoxybenzamine

Question 2

Which drugs are alpha1 selective antagonists? What is their common suffix?

Answer 2

Prazosin, Terazosin, Tamsulosin, Doxazosin, Alfuzosin, Silodosin; -osin

Question 3

What are the major cardiovascular effects of alpha antagonistic drugs?

Answer 3

Decreased PVR and BP, postural HTN, reflex tachycardia

Question 4

What are the major genitourinary effects of alpha antagonistic drugs?

Answer 4

SM relaxation in prostate, decreases urine flow resistance

Question 5

What are the major eye effects of alpha antagonistic drugs?

Answer 5

Pupillary dilator m. relaxation (miosis)

Question 6

What are the common clinical uses of alpha antagonists?

Answer 6

Pheochromocytoma, Chronic HTN, BPH, ED

Question 7

Which two alpha antagonists have the greatest selectivity for alpha1A receptors which are mostly found on the prostate?

Answer 7

Tamsulosin, Silodosin

Question 8

Which drugs are mixed adrenergic antagonists?

Answer 8

Labetalol, Carvedilol

Question 9

Which drugs are non-selective ß blockers/antagonists?

Answer 9

Propranolol, Pindolol, Nadolol, Penbutolol

Question 10

Which drugs are ß1 selective ß blockers/antagonists?

Answer 10

Metoprolol, Betaxolol, Acebutolol, Atenolol

Question 11

What is the common suffix of all ß blockers?

Answer 11

-olol

Question 12

Which ß blockers are full antagonists?

Answer 12

Atenolol, Nadolol, Propranolol, Betaxolol

Question 13

Which ß blockers are partial agonists?

Answer 13

Acebutolol, Labetalol, Penbutolol, Pindolol

Question 14

Which ß blockers are inverse agonists?

Answer 14

Carvedilol, Metoprolol

Question 15

What are the major heart effects of ß-blockers?

Answer 15

Negative inotropic/chronotropic effects

Question 16

What are the major blood vessel effects of ß-blockers?

Answer 16

Initial rise in PVR followed by decrease in PVR with chronic use

Question 17

What are the major RAAS effects of ß-blockers?

Answer 17

Inhibition of renin release

Question 18

What are the major respiratory effects of ß-blockers?

Answer 18

Increased airway resistance

Question 19

What are the major eye effects of ß-blockers?

Answer 19

Reduce aqueous humor production (reduce intraocular pressure)

Question 20

What are the major metabolic effects of ß-blockers?

Answer 20

Inhibit lipolysis, increase VLDL, decrease HDL, inhibit gluconeogenesis/glycogenolysis

Question 21

What are the major clinical uses for ß-blockers?

Answer 21

Angina pectoris, HTN, MI, Cardiac arrhythmias, Heart failure, Glaucoma, Hyperthyroidism