Adrenergic Drugs and Use

Question 1

What is the primary receptor activated and cause of Phenylephrine?

Answer 1

Alpha1; Mydriasis; SE = vasoconstriction, increased BP, bradycardia

Question 2

What is the primary receptor activated and cause of Clonidine?

Answer 2

Alpha1; General decrease in SNS activity (reduced BP, bradycardia)

Question 3

What is the primary receptor activated and cause of Norepinephrine?

Answer 3

Alpha1 = Alpha2; Cardiac stimulant, vasoconstriction

Question 4

What is the primary receptor activated and cause of Epinephrine?

Answer 4

Alpha1, Alpha2, ß1, ß2; Increase HR/contraction, increase systolic BP, relax bronchial SM, SkM tremor, increase glycogenolysis/gluconeogenesis

Question 5

What is the primary receptor activated and cause of Dobutamine?

Answer 5

ß1 agonist; Inotropic

Question 6

What is the primary receptor activated and cause of Isoproterenol?

Answer 6

ß1 = ß2 agonist; Inotropic/Chronotropic, increase CO, vasodilation, bronchodilation

Question 7

What is the primary receptor activated and cause of Terbutalin?

Answer 7

ß2 agonist; Bronchodilation, uterine relaxation

Question 8

What is the primary receptor activated and cause of Albuterol?

Answer 8

ß2 agonist; Bronchodilation, uterine relaxation

Question 9

What is the primary receptor activated and cause of Dopamine?

Answer 9

D1 = D2; Vasodilation of renal vasculature (D2 suppresses Nepi release)

Question 10

What is the primary receptor activated and cause of Fenoldopam?

Answer 10

D1 agonist; Vasodilation of renal vasculature

Question 11

What type of drug is Phentolamine?

Answer 11

Alpha antagonist

Question 12

What type of drug is Phenoxybenzamine?

Answer 12

Alpha antagonist

Question 13

What type of drug is Prazosin?

Answer 13

Alpha 1 selective antagonist

Question 14

What type of drug is Terazosin?

Answer 14

Alpha 1 selective antagonist

Question 15

What type of drug is Tamsulosin?

Answer 15

Alpha 1 selective antagonist

Question 16

What type of drug is Doxazosin?

Answer 16

Alpha 1 selective antagonist

Question 17

What type of drug is Alfuzosin?

Answer 17

Alpha 1 selective antagonist

Question 18

What type of drug is Silodosin?

Answer 18

Alpha 1 selective antagonist

Question 19

What are the primary uses of Tamsulosin and Silodosin?

Answer 19

Reduce prostate contraction b/c they are most selective for Alpha1A receptors which are in high concentration on the prostate

Question 20

What type of drug is Propranolol?

Answer 20

Non-selective ß antagonist/blocker

Question 21

What type of drug is Pindolol?

Answer 21

Non-selective ß antagonist/blocker

Question 22

What type of drug is Nadolol?

Answer 22

Non-selective ß antagonist/blocker

Question 23

What type of drug is Penbutolol?

Answer 23

Non-selective ß antagonist/blocker

Question 24

What type of drug is Metoprolol?

Answer 24

ß1 selective antagonist/blocker

Question 25

What type of drug is Betaxolol?

Answer 25

ß1 selective antagonist/blocker

Question 26

What type of drug is Acebutolol?

Answer 26

ß1 selective antagonist/blocker

Question 27

What type of drug is Atenolol?

Answer 27

ß1 selective antagonist/blocker

Question 28

Which ß antagonist/blocker’s are full antagonists?

Answer 28

Propranolol, Nadolol, Betaxolol, Atenolol

Question 29

Which ß antagonist/blocker’s are partial agonists?

Answer 29

Pindolol, Penbutolol, Acebutolol

Question 30

Which ß antagonist/blocker is an inverse agonists?

Answer 30

Metoprolol

Question 31

What is the benefit of using a partial ß antagonist VS a full ß antagonist?

Answer 31

Partial’s have a lower risk of bradycardia, VLDL/HDL increase, and other SE of ß blockers