Adrenergic Drugs and Use Flashcards
What is the primary receptor activated and cause of Phenylephrine?
Alpha1; Mydriasis; SE = vasoconstriction, increased BP, bradycardia
What is the primary receptor activated and cause of Clonidine?
Alpha1; General decrease in SNS activity (reduced BP, bradycardia)
What is the primary receptor activated and cause of Norepinephrine?
Alpha1 = Alpha2; Cardiac stimulant, vasoconstriction
What is the primary receptor activated and cause of Epinephrine?
Alpha1, Alpha2, ß1, ß2; Increase HR/contraction, increase systolic BP, relax bronchial SM, SkM tremor, increase glycogenolysis/gluconeogenesis
What is the primary receptor activated and cause of Dobutamine?
ß1 agonist; Inotropic
What is the primary receptor activated and cause of Isoproterenol?
ß1 = ß2 agonist; Inotropic/Chronotropic, increase CO, vasodilation, bronchodilation
What is the primary receptor activated and cause of Terbutalin?
ß2 agonist; Bronchodilation, uterine relaxation
What is the primary receptor activated and cause of Albuterol?
ß2 agonist; Bronchodilation, uterine relaxation
What is the primary receptor activated and cause of Dopamine?
D1 = D2; Vasodilation of renal vasculature (D2 suppresses Nepi release)
What is the primary receptor activated and cause of Fenoldopam?
D1 agonist; Vasodilation of renal vasculature
What type of drug is Phentolamine?
Alpha antagonist
What type of drug is Phenoxybenzamine?
Alpha antagonist
What type of drug is Prazosin?
Alpha 1 selective antagonist
What type of drug is Terazosin?
Alpha 1 selective antagonist
What type of drug is Tamsulosin?
Alpha 1 selective antagonist
What type of drug is Doxazosin?
Alpha 1 selective antagonist
What type of drug is Alfuzosin?
Alpha 1 selective antagonist
What type of drug is Silodosin?
Alpha 1 selective antagonist
What are the primary uses of Tamsulosin and Silodosin?
Reduce prostate contraction b/c they are most selective for Alpha1A receptors which are in high concentration on the prostate
What type of drug is Propranolol?
Non-selective ß antagonist/blocker
What type of drug is Pindolol?
Non-selective ß antagonist/blocker
What type of drug is Nadolol?
Non-selective ß antagonist/blocker
What type of drug is Penbutolol?
Non-selective ß antagonist/blocker
What type of drug is Metoprolol?
ß1 selective antagonist/blocker
What type of drug is Betaxolol?
ß1 selective antagonist/blocker
What type of drug is Acebutolol?
ß1 selective antagonist/blocker
What type of drug is Atenolol?
ß1 selective antagonist/blocker
Which ß antagonist/blocker’s are full antagonists?
Propranolol, Nadolol, Betaxolol, Atenolol
Which ß antagonist/blocker’s are partial agonists?
Pindolol, Penbutolol, Acebutolol
Which ß antagonist/blocker is an inverse agonists?
Metoprolol
What is the benefit of using a partial ß antagonist VS a full ß antagonist?
Partial’s have a lower risk of bradycardia, VLDL/HDL increase, and other SE of ß blockers
