Konorev Adrenergic Agonist Drugs

Question 1

Which drugs are direct alpha agonists?

Answer 1

Phenylephrine, Clonidine

Question 2

Which drugs are direct mixed agonists?

Answer 2

Norepinephrine, Epinephrine

Question 3

Which drugs are direct ß agonists?

Answer 3

Dobutamine, Isoproterenol, Terbutaline, Albuterol

Question 4

Which drugs are direct DA agonists?

Answer 4

Dopamine, Fenoldopam

Question 5

What type of GPCR are alpha1 receptors associated with?

Answer 5

Gq

Question 6

What type of GPCR are alpha2 receptors associated with?

Answer 6

Gi

Question 7

What type of GPCR are ß receptors associated with?

Answer 7

Gs

Question 8

What type of GPCR are D1 and D5 receptors associated with?

Answer 8

Gs

Question 9

What type of GPCR are D2-D4 receptors associated with?

Answer 9

Gi

Question 10

What are the major effects of activation of alpha1 receptors?

Answer 10

Vascular contraction, pupillary dilator m. contraction (dilation), increased heart contraction, prostate contraction

Question 11

What are the major effects of activation of alpha2 receptors?

Answer 11

Platelet aggregation, inhibition of NT release, vascular contraction, inhibition of lipolysis

Question 12

What are the major effects of activation of ß1 receptors?

Answer 12

Increase force/rate of heart contraction, increase renin release

Question 13

What are the major effects of activation of ß2 receptors?

Answer 13

SM relaxation, increased K+ uptake in SkM, activation of gluconeogenesis/glycogenolysis

Question 14

What are the major effects of activation of ß3 receptors?

Answer 14

Relax detrusor m., activate lipolysis

Question 15

What is the major effect of activation of D1 receptors?

Answer 15

Dilation of renal blood vessels

Question 16

What is the major effect of activation of D2 receptors?

Answer 16

Modulate NT release from nerve endings

Question 17

Which receptor(s) does Epinephrine activate? What are the major effects of Epinephrine?

Answer 17

alpha1 = alpha2, ß1 = ß2; Increase HR/contraction force, increase systolic BP, relax bronchial SM, increase K+ uptake in SkM (m. tremors), increase glycogenolysis/gluconeogenesis

Question 18

Which receptor(s) does Norepinephrine activate? What are the major effects of Norepinephrine?

Answer 18

alpha1 = alpha2, ß1; Vasoconstriction, increase cardiac contraction but reduce HR, increase PVR

Question 19

Which specific receptor does Nepi not activate and what is the effect of that?

Answer 19

ß2, no bronchodilation and vasodilation

Question 20

Which receptor(s) does Phenylephrine activate? What are the major effects of Phenylephrine?

Answer 20

alpha1 > alpha2; Mydriasis, vasoconstriction, increased BP, bradycardia

Question 21

Which receptor(s) does Clonidine activate? What are the major effects of Clonidine?

Answer 21

alpha2 > alpha1; Decreases SNS activity by acting at level of brainstem; decreases BP, bradycardia

Question 22

Which receptor(s) does Isoproterenol activate? What are the major effects of Isoproterenol?

Answer 22

ß1 = ß2; Increases CO, vasodilation, decrease arterial pressure, bronchodilation

Question 23

Which receptor(s) does Dobutamine activate? What are the major effects of Dobutamine?

Answer 23

ß1; Inotropic actions

Question 24

Which receptor(s) do Terbutaline and Albuterol activate? What are the major effects of Terbutaline and Albuterol?

Answer 24

ß2; Bronchodilation, uterine relaxation

Question 25

Which receptor(s) does Dopamine activate? What are the major effects of Dopamine?

Answer 25

D1 = D2; D1 –> vasodilation of renal vasculature, D2 –> suppress Nepi release