CYP Inducers and Inhibitors

Question 1

Which drugs induce CYP450 enzymes?

Answer 1

Carbamazepine, Phenytoin, Phenobarbital, Isoniazid, Rifampin

Question 2

Which drugs inhibit CYP450 enzymes?

Answer 2

Fluoxetine, Omeprazole, Cimetidine, Ketoconazole

Question 3

What are environmental things that can induce the CYP450 enzymes?

Answer 3

Chronic ethanol, aromatic hydrocarbons, St. John’s Wort

Question 4

What are environmental things that can inhibit the CYP450 enzymes?

Answer 4

Grapefruit juice

Question 5

What is the effect on the CYP450 enzymes of Carbamazepine?

Answer 5

Inducer

Question 6

What is the effect on the CYP450 enzymes of Fluoxetine?

Answer 6

Inhibitor

Question 7

What is the effect on the CYP450 enzymes of Isoniazid?

Answer 7

Inducer

Question 8

What is the effect on the CYP450 enzymes of Phenobarbital?

Answer 8

Inducer

Question 9

What is the effect on the CYP450 enzymes of Omeprazole?

Answer 9

Inhibitor

Question 10

What is the effect on the CYP450 enzymes of Ketoconazole?

Answer 10

Inhibitor

Question 11

What is the effect on the CYP450 enzymes of Cimetidine?

Answer 11

Inhibitor

Question 12

What is the effect on the CYP450 enzymes of Phenytoin?

Answer 12

Inducer