Konorev Corticoids

Question 1

Blocks the conversion of cholesterol to pregnenolone

Answer 1

Aminoglutethimide

Question 2

P450 inhibition, Reduces synthesis of adrenal and sex hormones

Answer 2

Ketoconazole

Question 3

Inhibition of steroid 11-hydroxylation

Relatively selectively suppresses formation of cortisol and corticosterone

Answer 3

Metyrapone

Question 4

Multiple actions:
Na+ ionofore, Ca2+ ionofore
Protein kinase C and adenylyl cyclase inhibitor
Non-selective cytotoxic action on adrenal cortex

Answer 4

Mitotane

Question 5

Stabilizes hsp90-GR complex in cytosol, prevents nuclear translocation of
GR

Answer 5

Mifepristone

Question 6

Glucocorticoid receptor antagonist

Answer 6

Mifepristone

Question 7

Progesterone receptor antagonist

Answer 7

Mifepristone

Question 8

Aldosterone receptor antagonist

Also an antagonist at androgen receptor

Answer 8

Spironolactone

Question 9

competitive antagonist of aldosterone at mineralocorticoid receptors. Lower affinity for androgen receptors vs. spironolacton

Answer 9

Eplerenone

Question 10

what is a DXA?

Answer 10

“duel energy xray absorptiometry” enhanced form fo xray tech used to measure bone loss. established standard for measuring bone mineral density (BMD)

Question 11

Was used for breast cancer treatment (was replaced by tamoxifen and aromatase inhibitors). Adrenocortical cancer

Answer 11

Aminoglutethimide

Question 12

indicated to suppresses androgenic hair loss

Answer 12

ketoconazole

Question 13

indicated to tx cushing’s syndrome

Answer 13

ketoconazole

Question 14

indicated to tx prostate cancer

Answer 14

ketoconazole

Question 15

indicated for cushing’s in pregnant women

Answer 15

metyrapone

Question 16

indicated for adrenal carcinoma

Answer 16

mitotane

Question 17

indicated for hypercortisolism in adult patients with endogenous cushing’s, anti-progesterone action and can be used to terminate pregnancy

Answer 17

mifepristone

Question 18

indicated for hirsutism

Answer 18

spironolactone

Question 19

indicated for primary hyperaldosteronism

Answer 19

spironolactone

Question 20

indicated for HTN and heart failure, reduces cardiac remodeling

Answer 20

eplerenone

Question 21

ketoconazole and arvostatin

Answer 21

myalgia and myoglobinuria: ketoconazole is a strong cyp 3AF, the main pathway of artovastatin metabolism. ketoconazole increases the half life and plasma levels of this drug and may cause atorvstatin toxicity: liver damage, skeletal muscle damage, rhabdomyolysis, which may lead to acute renal failure