Know This Antipsychotic Agents

Question 1

↑ DA –> Positive Symptoms

Answer 1

Delusions
Hallucinations
Disordered thoughts

Question 2

↓ DA –> Negative Symptoms

Answer 2

Blunted affect-anhedonia

Alogia - Asociality

Question 3

Effects of Antipsychotic Receptor Block– Mesolimbic pathway

Answer 3

↓ + symptoms of schizophrenia

Question 4

Mesocortical pathway

Effects of Antipsychotic Receptor Block

Answer 4

↑ - symptoms of schizophrenia

Question 5

Nigrostriatal pathway

Effects of Antipsychotic Receptor Block

Answer 5

↑ Extrapyramidal Side Effects

Question 6

Tuberoinfindibular pathway

Effects of Antipsychotic Receptor Block

Answer 6

Hyperprolactinemia

Question 7

Effects of Antipsychotic Receptor Block

Hypothalamus

Answer 7

Poikilothermia, Weight Gain

Question 8

Chemoreceptor Trigger Zone

Answer 8

Anti-Emetic Effect

Question 9

Acute dystonia (onset 1-5 days)

Answer 9

Torticollis, trismus, opisthotonos

Treatment: anticholinergic agents [diphenhydramine-benztropine]

Question 10

Akathisia (onset 6-60 days)

Answer 10

Motor restlessness – “can’t sit still”

Treatment: reduce dose – change drug – anticholinergic – β blocker, benzodiazepine

Question 11

Pseudoparkinsonism (onset 5-90 days)

Answer 11

Tremor, bradykinesia, rigidity, shuffling gait

Treatment: anticholinergic agents

Question 12

Tardive dyskinesia (onset 3-6 months or longer, 20-40% incidence in elderly females)

Answer 12

D2 receptor supersensitivity?

Involuntary movements of orofacial muscles, choreathetoid movements

Treatment: rarely effective, prevention best strategy