Antidepressants, Anti-manic drugs & Mood Stabilizers Flashcards
1
Q
block 5HT pre-synaptic reuptake pump
A
• SSRIs:
2
Q
block NE and 5-HT reuptake pumps
A
• SNRIs:
3
Q
blocks 5-HT2A, 5-HT2C, 5-HT3, a-2-adrenergic receptors
A
• Mirtazapine:
4
Q
increases whole-body NE, weakly blocks reuptake of DA
A
• Buproprion
5
Q
most potent action is blockade of post-synaptic 5-HT2. Block reuptake of 5-HT and NE.
A
• Trazodone and nefazodone
6
Q
block reuptake of 5-HT and NE, (and, to lesser extent, DA), as well as H1, muscarinic cholinergic receptors and a-1.
A
• Tricyclics:
7
Q
irreversibly inhibit MAO-A and MAO-B, increasing levels of 5-HT and NE.
A
• MAOIs
8
Q
a new antidepressant, is an SSRI + 5HT1A partial agonist.
A
• Vilazodone,
9
Q
- Pluses: Time-tested, very effective, more effective in severe depression, can monitor blood levels. Newer TCAs (secondary amines such as desipramine and nortriptyline) have fewer side effects than older TCAs (tertiary amines, such as imipramine and amitryptyline)
- Minuses: Hypotension, orthostasis, anticholinergic side effects, weight gain, sexual side effects, dangerous in overdose (10 day supply can be lethal)
A
TCAs
10
Q
- Pluses: Can be very effective in non-responsive patients, especially atypical depression, time-tested.
- Minuses: Hypotension, orthostasis, dry mouth, constipation, urinary retention, sexual side effects, weight gain, hypertensive crisis–Tyramine reaction
A
MAOIs
11
Q
- Pluses: Safe, effective, multiple indications: Generalized Anxiety Disorder, social anxiety, panic, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Premenstrual Dysphoric Disorder
- Minuses: Diarrhea, nausea, jitteriness/anxiety, sexual side effects, drug interactions: P450 inhibition
A
SSRIs
12
Q
- Pluses: Some evidence more effective than SSRIs, safe, better tolerated than TCAs, multiple indications
- Minuses: Sexual side effects, sweating, increased diastolic blood pressure, withdrawal syndrome (flu-like, “electric shocks”)
A
SNRIs
13
Q
TCAs
A
- Pluses: Time-tested, very effective, more effective in severe depression, can monitor blood levels. Newer TCAs (secondary amines such as desipramine and nortriptyline) have fewer side effects than older TCAs (tertiary amines, such as imipramine and amitryptyline)
- Minuses: Hypotension, orthostasis, anticholinergic side effects, weight gain, sexual side effects, dangerous in overdose (10 day supply can be lethal)
14
Q
SSRIs
A
- Pluses: Safe, effective, multiple indications: Generalized Anxiety Disorder, social anxiety, panic, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Premenstrual Dysphoric Disorder
- Minuses: Diarrhea, nausea, jitteriness/anxiety, sexual side effects, drug interactions: P450 inhibition
15
Q
MAOIs
A
- Pluses: Can be very effective in non-responsive patients, especially atypical depression, time-tested.
- Minuses: Hypotension, orthostasis, dry mouth, constipation, urinary retention, sexual side effects, weight gain, hypertensive crisis–Tyramine reaction