Ketamine Drug Sheet

Question 1

Ketamine

- Presentation

Answer 1

200 mg in 2 ml glass ampul

Question 2

Ketamine

- Contraindications

Answer 2

• Non- Traumatic brain injury with a SBP of >180

Question 3

Ketamine

- Mode of action

Answer 3

Anaesthetic agent with analgesic properties at low doses

Antagonist at the NMDA receptor

Question 4

Ketamine

- Indications

Answer 4

Intubation
Analgesia
Sedation (agitation or pt movement during CPR)

Question 5

Ketamine

- Precautions

Answer 5

May exacerbate cardiovascular conditions due to its effects on BP and HR

Question 6

Ketamine

- Adverse Affects

Answer 6

• CV Hypertension, tachycardia
• Resp: transient resp depression/ aponea rare
  CNS: Emergence reactions, increased skeletal muscle tone
  GI: Nausea and vomiting
  Other: Injection site pain, hyper-salivation, lacrimation, nystagmus, diplopia

Question 7

Ketamine Affects IV
Onset
Duration

Answer 7

Onset 30 seconds

Duration 5-10 minutes

Question 8

Ketamine Affects IN
Onset
Peak
Duration

Answer 8

Onset 5 minutes
Peak 20 minutes
Duration 45 minutes

Question 9

Ketamine Affects IM
Onset
Duration

Answer 9

Onset 3-4 minutes

Duration 12-25 minutes

Question 10

Is Ketamine safe to use in pregnancy and breastfeeding?

Answer 10

Pregnancy- yes

Breast feeding- monitor infant for reactions- unlike to be harmful in emergency indications