Fentanyl Drug Sheet

Question 1

Fentanyl

- Pharmacology

Answer 1

A synthetic opioid analgesic 
Causes:
- CNS: Depression (analgesia) 
- CNS: Respiritory Depression (aponea) 
- CNS: Dependence (addiction)
- CARDIO: decreased velocity through the AV node

Question 2

Fentanyl

- Presentation

Answer 2

100 mcg in 2ml glass ampul

250 mcg in 1 ml ampul (IN only)

Question 3

Fentanyl

- Indications

Answer 3

• Sedation to: facilitate intubation, maintain intubation, facilitate trans-thoracic passing, facilitate synchronised cardio-version
• CPR interfering Patient (ALS)
• Analgesia IV or IN: Hypersensitivity to morphine, hypotension, Short duration of action, renal impairment, nauseas/vomiting, serve headache.

Question 4

Fentanyl

- Contrindications

Answer 4

• Hypersensitivity

- Late second stage labour

Question 5

Fentanyl

-Precautions

Answer 5

• Resp depression (COPD)
• Elderly/frail
• Addiction to opioids
• Known hepatic impairment
• Current asthma
• Rhinitisis, Rhinorea, Facial trauma (IN)
• Pt on monoamine oxide inhibitors

Question 6

Fentanyl

-Route

Answer 6

IV
IN
IV infusion

Question 7

Fentanyl

-Side effects

Answer 7

• Respiratory depression
• Apnoea
• Rigidity of diagram and intercostals
• Bradycardia

Question 8

Fentanyl IV Effects

• Onset
• Duration
• Peak

Answer 8

Onset- immediately
Duration- 30-60 minutes
Peak <5 minutes

Question 9

Fentanyl lN Effects

- Peak

Answer 9

Peak- 2 minutes

Question 10

Fentanyl

- Metabolism

Answer 10

By the liver, excrete by the kidneys

Question 11

When is fentanyl preferred to morphine for analgesia?

Answer 11

Short duration of action 
Hypotension
Nausea/vomiting
Contraindication to morphine
Serve headache