Ketamine

Question 1

What type is Ketamine?

Answer 1

Dissociative anaesthetic with analgesic effects. an NMDA receptor agonist

Question 2

What is the action of Ketamine?

Answer 2

Dissociates the central nervous system from painful stimuli. At low doses it causes a trance like state with analgesia and amnesia with retention of protective airway reflexes spontaneous resp and CV activity

Question 3

What is the cellular action of Ketamine?

Answer 3

ketamine antagonises NMDA an excitory neurotransmitter that transmits pain , perception of pain awareness and surroundings. Ketamine requires glycine and glutamate to open the channel. The channel causes Na+ & Ca++ to enter the cell & K+ to leave . Ketamine blocks the the channel without binding to the glycine or the glutamate receptors. It also decreases the presynaptic release of glutamate and increases the effects of GABBA