Frusemide

Question 1

What type is Frusemide?

Answer 1

Loop Diuretic

Question 2

What is the action of Frusemide?

Answer 2

A potent loop diuretic which produces increassed urine output by inhibiting Na+ reabsorbtion in the lumen of the nephron vian organic base pump in the proximal tubule cells. This acts upon the ascending loop of Henle where it inhibits the NA+/K+/2Cl co transporter decreasing reabsorbtion of these Ions and decreased H2O reabsorbtion.

Question 3

Onset, Peak, Duration

Answer 3

IM 10min 30 mins 2-3hrs

IV 5min 20-30min 2-3hrs

Question 4

Use of Frusemide/

Answer 4

Cardiogenic Pulmonary Oedema

Question 5

Adverse effects Hypovolaemia

Answer 5

Large doses can lead to decreased circulating volume due to excessive diuresis leading to hypovolaemic shock

Question 6

Adverse effects dysrythmias

Answer 6

Potassium loss can precipitate dysrythmias by an ^ in K+excretion in urine this causes a decrease in the RMP of myocytes and requiring greater stimulus for an AP

Question 7

Contraindications of Frusemide

Answer 7

Bp < 100mmhg

Pt’s< 16 yrs

Question 8

Prearation of Frusemide

Answer 8

40 mg (4ml) ampoule

Question 9

Dose of Frusemide

Answer 9

40 mg IV/IM repeat once 10mins max 2 doses
If on oral diuretics
80 mg IV/IM repeat once 10mins max 2 doses