Amiodorone

Question 1

How does Amiodorone slow the sinus rate and the refractory period of the AV node?

Answer 1

By blocking the K+(Potassium) channels in phase 3 of AP thereby increasing the QT interval

Question 2

How does Amiodorone decrease peripheral vascular resistance?

Answer 2

By inhibiting alpha & beta adrenoreceptors resulting in relaxation of vascular smooth muscle and vasodialation.

Question 3

What is the CA use of Amiodorone?

Answer 3

CA VF & pulseless VT refractory to shocks &adrenaline

Question 4

What is the Dysrythmia uses of Amiodorone?

Answer 4

Tachycardia > 16yrs LOC A-V and symptomatic with wide QRS>0.12s OR
LOC P-U HR >160 post cardioversion

Question 5

What are the adverse effects of Amiodorone?

Answer 5

Hypotension decreasedvascular tone from blocked alpha &beta adrenoreceptors
Bradycardia slow SR & ^ refractory period, prolonged QT interval
Dysrythmia, prolonged QT=Toursade de Pointes

Question 6

What is the preperation of Amiodorone?

Answer 6

150mg in 3ml or (50mg:1ml)

Question 7

What is the dose of Amiodorone in CA, VF VT patients >16

Answer 7

> 16 300mg IV bolus repeat once 150mg max 450mg

Question 8

What is the dose of Amiodorone in CA, VF VT patients <16

Answer 8

5mg/kg (0.1ml/kg) IV/IO repeat 10mg/kg(0.2ml/kg)

Question 9

What is the dose of Amiodorone in Tachycardias > 16yrs

Answer 9

50mg (1ml) repeat 3mins, max 6 doses (300mg)