Adrenaline

Question 1

What type is Adrenaline?

Answer 1

Sympathomimetic

Question 2

What effect doe Adrenaline have on peripheral circulation?

Answer 2

Adrenaline causes peripheral vasoconstriction ^ perfusion pressure & decreased capillary permeability

Question 3

How does Adrenaline effect anaphylaxis?

Answer 3

Adrenaline acts on Alpha adrenoreceptors opening Ca+ channels leading to ^ intracellular Ca+ causing contraction of smooth muscles and vasculature

Question 4

What are the beta 1 effects of Adrenaline>?

Answer 4

Beta 1 causes ^ myocardial excitability (dromotropic) Tachycardia (chronotropic)& myocardial contractility (inotropic)

Question 5

How does Adrenaline affect Beta 1 receptors?

Answer 5

By ^ cAMP leads to ^ Ca+ influx in Phase 2 of AP causing increased FOC.

Question 6

How does Adrenaline cause Bronchodialation?

Answer 6

^ cAMP on smooth muscles = dilation.

Question 7

How does Beta 2 stimulation help in anaphylaxis?

Answer 7

B2 receptors on MAST cells stabilised which prevents further degranulation and consequential histamine release.

Question 8

What are the indications for Adrenaline

Answer 8

Asthma, Anaphylaxis, Croup, Cardiac arrest Cardiogenic shock, Bradycardia
Newborn resuscitation

Question 9

What are the adverse effects of Adrenaline?

Answer 9

Tachycardia,Nausea/ Vomiting, Dysrhythmias (VF),Pupillary dilation,Anxiety, Hypertension

Question 10

What are the preparations of Adrenaline?

Answer 10

1:1000 1mg/1ml
1:10000 1mg/10ml
1mg 1:10000 in 90ml Hartmanns via burette & microdrip