Atropine Flashcards
What type is Atropine?
Anticholinergic
What is the action of Atropine on HR?
^ HR by ^ intrinsic rate of SA node and increasing the conduction through the AV node
What is the action of Atropine on smooth muscle
Reduces smooth muscle contraction causing Miosis reduced GI motility and reduced bladder tone.
How does Atropine cause decreased sweat saliva bronchial and gastric secretions.
By blocking exocrine gland gland activity
What is the onset peak and duration of IV Atropine?
O < 2min, P < 5min, D 2-6 hrs
What are the uses of Atropine
*Bradycardia+ key signs of compromise
*Organophosphates+HR <80&/or SBP<80mm/hg or ^
chest secretions/crackles/creps
*Nerve agents CBR incident mild symptomsor no
combipen
What are the adverse effects of Atropine?
- Blurred Vision
- Agitation/Delerium/Hallucinations
- Dry mouth
- Dysrythmias
- Hyperthermia,
- Urinary retention
- Nausea & Vommiting
- Tachycardia
What is the preparation of Atropine?
IV 600mcg/1ml ampoule
IM dilute with 5ml nacl (100mcg:1ml)
What is the adult dose for Bradycardia with key signs of haemodynamic compromise?
> 16yrs IV 600mcg repeat 1min max 3mg
>16yrs IM 600mcg repeat 3min max 3mg
What is the Adult dose of Atropine in Organophosphates
with HR<80bpm, BP<80 secretions ?crackles or creps?
Adult 600mcg (1ml) IV repeat 1 min no max 2mg(3.3ml) IM repeat 3 min no max
What is the Pead dose of Atropine in Organophosphates
with HR<80bpm, BP<80 secretions ? crackles or creps?
Peads IV/IO 20mcg/kg (0.2ml/kg) diluted nil repeat
Peads IM 20mcg/kg (0.3ml/kg) undiluted nil repeat
What is the Pead dose for Bradycardia with key signs of haemodynamic compromise?
Peads IV/IO 20mcg/kg (0.2ml/kg) diluted nil repeat
Peads IM 20mcg/kg (0.3ml/kg) undiluted nil repeat
What are the doses for nerve agent? CBR incident mild symptoms nil combipen?
> 16 yrs 2mg im bolus repeat 3mins no max
<16yrs 2mg IM bolus repeat once 30mins max 2 doses
How dose Atropine effect Bradycardia?
Ach binnds to M2 muscarinic receptors in the SA/AV nodes decreasing cAMP & ^ potassium leaving the cell. This causes a decrease in the rise of Phase 4 of AP slowing HR by slowing conduction of AP through the AV node.
Atropine antagonises these effects ^ SA nodal rate conduction through AV node and ^ HR
what rhythms won’t Atropine work on?
Asystole & complete Heart Block. Atropine works on SA node and conduction throughh the AV node , both rhythyms have nil activity above the AV node
