Keep Bleeding

Question 1

Heparin

Answer 1

Cofactor for activation of antithrombin

Question 2

Lepirudin, bivalirudin

Answer 2

Directly inhibit thrombin

Good alternative for patients w/ HIT

Question 3

Warfarin

Answer 3

Interferes w/ normal synthesis & gamma-carboxylation of vitamin K dependent clotting factors II, VII, IX, X, and proteins C & S

Question 4

Thrombolytics

Answer 4

Directly or indirectly aid conversion of plasminogen to plasmin, which cleaves thrombin & fibrin clots

Question 5

Streptokinase

Answer 5

Thrombolytic

Question 6

Urokinase

Answer 6

Thrombolytic

Question 7

tPa

Answer 7

Thrombolytic

AKA alteplase

Question 8

APSAC

Answer 8

Thrombolytic

AKA antistreplase

Question 9

Aspirin

Answer 9

Acetylates & irreversibly inhibits COX 1 & COX 2

Question 10

Clopidogrel, ticlopidine

Answer 10

Inhibit platelet aggregation by irreversibly blocking ADP receptors; inhibit fibrinogen binding by preventing glycoprotein IIb/IIIa expression

Question 11

Cilostazol, dipyridamole

Answer 11

Phosphodiesterase III inhibitors; increase cAMP in platelets thus inhibiting platelet aggregation; vasodilators

Question 12

Abciximab

Answer 12

Monoclonal antibody that binds glycoprotein receptor IIb/IIIa on activated platelets, preventing aggregation