Kach: Antidepressants Flashcards
____ could be the link between inflammation & mood disorders
Nitric Oxide
Tricyclic affect which neurotransmitters
5HT & NE
TCAs are best for Anxiety / lack of sleep Depression
Some treat bed wetting
Are they ever used in pain?
Yes, Chronic, intratable, neuropathy Fibromyalgia
TCAs reach peak levels in…
2 -4 hrs
TCAs take 10- 14 days to have effect
How long for maxium effect?
4 - 8 weeks
Contradictions for TCAs
Recent MI
Myelography within 24, interaction with dyes
Use with caution in CV disorders
Anything that Anticholinergic will make it worse
Angle- closure glaucoma
Urinary retention
Prostate hypertrophy
GI Gu surgey
TCAs do this to the seizure threshold
Low it
These types of affects from TCAs cause blurred vision & photophobia
Anticholinergic
Orthostatic hypotension, hypertension, tachycardia and cardiac arrhythmias happen with these antidepressants
TCA
Contradictions include:
Pheochromocytoma
CV disease (hypertension, CAD, Angina, CHF)
HISTORY of headaches
MAOI
Contradictions include
Pheochromocytoma
CV diseases
History of headache
Liver renal impairment
Bipolar
Seizure disorder
Hyperthyroidism
Pregnant or breastfeeding
Maoi
Period of ___ weeks maybe needed after stopping SSRI and starting MAOI
6
Combination of Insulin & oral antidiabetic agents may have this out come when mixed with MAOI
HYPOGLYCEMIA
Why would you Discontinue an MAIO if a patient gets a severe headache
It could be severe hypertension from a reaction with Tyramine
Treats Depression, OCD, Panci Attacks, Bulimia, PMDD,PTSD,Social phobias/ Anxiety
4 weeks is necessary for full therapeutic effects
SSRI
