Chapter 14 Book Depression Flashcards

1
Q

SE: Agitation, insomnia, headache, NV, Sexual Dysfunction, hyponatremia

Class

A

SSRI

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2
Q

This SNRI inhibits reuptake of norepinephrine more than 5 HT.

SE: OH, constipation, sweating, increased HR, palpitations, difficulty urinating, decreased appetite, Sexual Dysfunction

A

Levomilnacipran

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3
Q

This SNRI is approved for GAD.

SE: N, xerostomia, insomnia, somnolencia, constipation, reduce appetite, fatigue, sweating, blurred vision

A

Duloxetine

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4
Q

Venlafaxine SNRI is popular choice after SSRI.

WARNING

A

Monitor BP esp at high levels

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5
Q

Nefazodone, Trazodone, Vilazodone, Vortioxetine

This class

A

Serotonin Antagonist and Reuptake Inhibitor

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6
Q

Bupropion NDRI smoking stopper at low dose (poor man’s coccaine)

Has this Contradiction

A

Seizures

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7
Q

Use caution in older adults with Cardiac Problems, Elevated intraocular pressure, urinary retention, Hyperthyroidism, seizures, liver & Kidney dysfunction. Lethal in OD

A

Tricyclic antidepressants

Amitriptyline
Amoxapine
Doxepin
Imipramine
Nortriptyline

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8
Q

Disruptive mood dysregulation is….

Why was the diagnosis invented….

A

Constant & severe irritability and anger Ages 6 - 18

To prevent them from being labeled bipolar and taking wrong meds.

They grow outta it and become either depressed or Anxious

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9
Q

Persistent depressive disorder/ Formerly Dysrhthmias

Is this level ____ of depression that last 2 years Most days of the week

In addition have atleast 2 of the following: appetite problems, insomnia/ hypersomia, low energy, poor Self-Esteem, difficulty thinking hopelessness

A

Low level

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10
Q

Premenstrual Dysphoric Disorder

Can best be relieved by..

Which SSRIs

A

Regular exercise, carbohydrate rich foods & sleep, acupuncture, light therapy, relaxation.

Fluoxetine, Sertraline, Controlled release Paroxetine

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11
Q

Major depressive disorder is characterized by 5 or more symptoms of depression lasting atleast how long….

A

2 weeks

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12
Q

Can a person whose son just died last month be considered clinically depressed

A

Yes

Now the Bereavement exclusion is removed from the DSM

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13
Q

Leading cause of disability worldwide.

Most common psychological illness in USA

A

Depression

Anxiety

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14
Q

Women are more depressed than men.

Biracial people are the most depressed race

A

T & T

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15
Q

Two main neurotransmitters involved in mood are..

A

5 HT & norepinephrine

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16
Q

Serotonin or Norepinephrine

Attention
Behavior
Sleep
Appetite
Sex drive
Impulse control
Irritability

A

Norepinephrine

Attention
Behavior

Serotonin

Sleep
Appetite
Sex drive
Impulse control
Irritability

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17
Q

Hyperactivity of HPA & increased urine cortisol & elevated corticotrophin-releasing hormones
Are associated with depression?

A

T

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18
Q

C-reactive protein & interleukin-6 may play a role in depression. What do they both do?

A

Inflammation

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19
Q

This score on the PHQ-9 is qualification for a referral to mental help

A

> 9

20
Q

This is the Hallmark symptom of depression

A

Sleep pattern disturbance

21
Q

Words to describe Mood are….

A

Euthymic (normal)
Euphoric (Overly happy)
Angry
Irritable
Anxious
Apethic

22
Q

Moods can change quickly and need to be assessed often

T or F

A

F

Moods last from several hours to days.

Feelings & emotions change frequently

23
Q

Moods include

Worthless, guilt, helpless, hopeless, anger

T or F

A

F

These are feelings which can change in minutes. Moods are Euthymic, Euphoric, angry, irritable, anxious, apathetic

24
Q

Inability to solve problems may lead to this feeling / emotion

A

Helplessness

25
Q

Are psychotic feature Hallucinations ever present with depression?

A

Yes, in severe

26
Q

The core symptom of depression in children & adolescents is…

A

Same as adults

Sadness & loss of pleasure

27
Q

3 phases of treatment for major depression & time frame

A

Acute 6 - 12 weeks (reduction of depression & restoration of function)

Continuation phase 4 - 9 months ( Prevent relapse )

Maintenance >1 year prevent further episodes. Meds may be Discontinued

28
Q

Fluoxetine gives energy or makes tired

Mirtazapine gives energy or makes tired

Bupropion makes horny?

Give these for chronic pain

A

Fluoxetine gives energy

Mirtazapine makes tires

Bupropion makes horny

TCA or Duloxetine

29
Q

Do SSRI have anticholinergic effects
Dry mouth, blurry vision, urinary retention

A

No

30
Q

Patient should Discontinue SSRI for how long before stating an MAIO

A

2 - 5 wks

31
Q

How long to be off SSRI before starting MAIO

A

2 - 5 weeks

32
Q

Esketamine affects this neurotransmitter

A

Glutamate

33
Q

No eating / drinking 2 hrs before esketamine

HTN = SE

When can patient drive themselves home after treatment

A

Can’t.

Must be monitored for 2 hrs

And no driving until following day

34
Q

Brexanolone is ….

Neurotransmitter….

Delivery method

Serious SE

A

Postpartum

GABA

IV over 2.5 days

Hypoxia, dry mouth, flushing, hot flashes

35
Q

2nd line of treatment for depression

A

TCAS

36
Q

TCAs

Major SE

A

Anticholinergic: Urine retention
Heart: Tachycardia
Sedative: Use at night

OD = Death

37
Q

Recent MI
Seizures
Narrow angle glaucoma
Preggers

Contradictions for…

A

TCAs

38
Q

SE of MAOI is HTN or hypotension

A

Both

Hypotension common

HTN with Tyramine

39
Q

BP should be monitored with these meds

A

MAIO

40
Q

HTN Crisis with MAIOs

Gastric lavage / charcoal maybe done if recent ingested

A

True

41
Q

Contradictions

Cerebrovascular disease
HTN CHF
Liver disease
Tyramine, L-tryptophan, dopamine
Recurrent headaches
Surgery in past 14 days
<16

A

MAIO

42
Q

SSRI can be used when preggers at the lowest effective dose. Except

Which SSRI has Contradictions of heart defects in fetus

A

Paroxetine

43
Q

Pre ECT Workup

Chest x ray
ECG
urine analysis
Cbc
Blood urea
Electrolyte

And Discontinue this med

A

Benzo

Stops the seizures

44
Q

Type of amnesia associated with ECT

A

Retrograde

Leading up to event and event itsefl

45
Q

Low frequency transcranical magnetic stimulation may be used for seizures patients - Not High frequency.

What is the only Contradictions to this procedure…

A

Metal implants, deep brain, cochlear implants.

46
Q

Are symptoms of major depressive disorder enough to interfere with a person’s social or job function

A

Yes