JVD 2019 #4 Humic Acid, a Polyphenolic Substance, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats, Calisir Flashcards
What are humic acids?
Humic acids are brown-black colored, polymeric, alkali-soluble organic acid fractions abundantly present in all soils (esp wetlands) and on the surfaces and bottoms of oceans and seas
At the 15 day period, how did the alveolar bone loss compare between the control ligature-only group, control no-ligature and test groups?
Alveolar bone loss was significantly higher in the control ligature-only group compared to the no-ligature, 20mg/kg, and 150mg/kg groups.
How did osteoclast number in the ligature only group compare to the other groups?
It was significantly higher compared to the no-ligature, L-20 and L-150 groups
What serum and gingival homogenate interleukins were evaluated? Was there a significant difference in the groups?
Enzyme-linked immunosorbent assays for interleukin 1b (IL-1b) and IL-10 were measured. IL-1b was significantly higher in serum and gingival homogenate in the ligature only group compared to the test groups.
IL-10 was highest in the control no-ligature group.