Jane's Abstract review Flashcards
Regenerative Approach to Bilateral Rostral mandibular Reconstruction in a Case Series of Dogs Fron Vet Sci Arzi, Cissell, Verstrate What were the components of the reconstruction?
Combination of intraoral and extraoral approaches Locking titanium plate Compression Resistant Matric infused with BMP
Regenerative Approach to Bilateral Rostral mandibular Reconstruction in a Case Series of Dogs Fron Vet Sci Arzi, Cissell, Verstrate What were the results of the case series?
Rostral mandibular defects in 5 dogs 3 dogs healed with intact gingival covering 2 dogs had complication of focal plate exposure and dehiscence
Regenerative Approach to Bilateral Rostral mandibular Reconstruction in a Case Series of Dogs Fron Vet Sci Arzi, Cissell, Verstrate How were the complications managed?
Covered exposed plates with mucosal flaps and re-sutured
Regenerative Approach to Bilateral Rostral mandibular Reconstruction in a Case Series of Dogs Fron Vet Sci Arzi, Cissell, Verstrate What were the follow up findings?
Mineralized tissue palpated at 2 weeks Solid bone formation within 3 months CT findings at 6 months showed newly regenerated mandibular bone with increased mineral volume
Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: a prospective study on 114 cases Vet Journal Bonfanti, Bertazzolo, Gracis What was the aim of the study?
To compare the results of cytological examinations of lesions following FNA, FN insertion and impression smears with histopath results
Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: a prospective study on 114 cases Vet Journal Bonfanti, Bertazzolo, Gracis What was diagnostic accuracies of dogs with neoplasia?
86 total samples with FNA, FNI and impression smears compared to histopath results FNA= 98% FNI=98% Impression smears=92%
Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: a prospective study on 114 cases Vet Journal Bonfanti, Bertazzolo, Gracis What was the diagnostic accuracies of cats with neoplasia?
FNA=96% FNI= 96% Impression smear= 96%
Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: a prospective study on 114 cases Vet Journal What was the conclusion of the study?
The high agreement with histopath suggests that cytological examinations by FNI, FNA and IS are all appropriate methods to correctly diagnose lesions of the oral cavity in dogs and cats
Vertical Mandibular Range of Motion in Anesthetized Dogs and Cats Front Sci Gracis, Zini How was the study designed?
260 dogs–divided into 4 subgroups based on BW 127 cats
Vertical Mandibular Range of Motion in Anesthetized Dogs and Cats Front Sci Gracis, Zini What were the results?
Dogs <5 kg = 67 mm Dogs 5-10 kg= 93 mm Dogs 10-25 kg= 115 mm Dogs >25 kg = 134 mm Cats= 62 mm
Vertical Mandibular Range of Motion in Anesthetized Dogs and Cats Front Sci Gracis, Zini What were the conclusions?
The vmROM and body weight were positively correlated in all populations except dog group 5-10 kg
Crown preservation of the mandiubalr first molar tooth impatct the strength and stiffness of 3 non-invasive fracture repair constructs in dogs Front Vet Sci Lothamer, Snyder What were the objectives of the study?
To test the strength and stiffness of 3 noninvasive mandibular fracture repair constructs and to characterize the impact that tooth crown preservation has on fixation strength for fractures occurring at the M1 LOCATION
Crown preservation of the mandiubalr first molar tooth impatct the strength and stiffness of 3 non-invasive fracture repair constructs in dogs Front Vet Sci Lothamer, Snyder How was it designed?
3 Treatment Groups 1.) composite only 2.) interdental wiring and composite 3.) transmucosal fixation screw and composite Crowns of teeth were amputated at the alveolar margin to simulate corwn loss on fixation strength and stiffness
Crown preservation of the mandiubalr first molar tooth impatct the strength and stiffness of 3 non-invasive fracture repair constructs in dogs Front Vet Sci Lothamer, Snyder What were the results?
Interdental wiring and composite demonstrated the greatest bending stiffness and load to failure IWC was best for mandibles with crown was removed compared to the other 2 groups All 3 were better with crowns than without
Bacterial profile of necrotic pulps in Cheetah J Zoo Wild Med Almasa, Bosman
36 microbial samples from 19 cheetahs Cultured for aerobic and anaerobic bacterial as well as PCR for the last 6 collected samples 54% of cultures were gram positive 45% of cultures were gram negative 63% were facultative anaerobes 28% were aerobic 8.4% were strict anaerobes Similar % for PCR results Best antimicrobials were amikacin and gentamicin
Dental and TMJ joint pathology of the eastern pacific harbor seal J Comp Path Aalderink, Nguyen, Kass
214 skulls examined Maxillary molar teeth had high variability of tooth roots Tooth fracture was rare as were periapical lesions Most common site for supernummerary were manidublar first premolars Over half of all speciments had alveolar bony changes consistent with periodontitis 34% had signs of TMJ osteoarthritis The left mandibular fossa was the most common location for TMJ-OA Bottom line: TMJ and perio problems in seals
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What was the objective?
To describe internal fixation for maxillofacial fractures using titanium miniplates and outcomes in 7 dogs
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What surgical approaches were used in the 7 dogs?
A combination of extra- and intra-oral surgical approaches
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What type of mini-plates were used?
Titanium non-locking miniplate
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate How long was the return to function?
Immediate return to normal function and occlusion
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate Why did one patient have the miniplates removed 1.5 years later?
Patient developed nasal aspergillosis
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What was the outcome for the 7 dogs?
Excellent long-term function and general lack of complications
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What was the outcome for the 7 dogs?
Excellent long-term function and general lack of complications
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate Why did one patient have the miniplates removed 1.5 years later?
Patient developed nasal aspergillosis
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate How long was the return to function?
Immediate return to normal function and occlusion
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What type of mini-plates were used?
Titanium non-locking miniplate
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What surgical approaches were used in the 7 dogs?
A combination of extra- and intra-oral surgical approaches
Internal Fixation of Severe Maxillofacial Fractures in Dogs Vet Surg Arzi and Verstrate What was the objective?
To describe internal fixation for maxillofacial fractures using titanium miniplates and outcomes in 7 dogs
Dental and TMJ joint pathology of the eastern pacific harbor seal J Comp Path Aalderink, Nguyen, Kass
214 skulls examined Maxillary molar teeth had high variability of tooth roots Tooth fracture was rare as were periapical lesions Most common site for supernummerary were manidublar first premolars Over half of all speciments had alveolar bony changes consistent with periodontitis 34% had signs of TMJ osteoarthritis The left mandibular fossa was the most common location for TMJ-OA Bottom line: TMJ and perio problems in seals
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”,
What was the inclusion criteria for cats in the study?
- Full mouth extractions performed and non-responsive
- No major co-morbidities
- no steroids or immunosuppressives (D/C’d 2 weeks before trial)
- negative for FIV, FeLV
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What does LAHSHAL stand for in the classification system, what do upper and lower case letters mean?
Each letter represents an anatomic location
(L = lip, A = alveolus, H = hard palate, and S = soft palate).
In this diagrammatic classification system, letters to the left of the S represent defects on the right side of the soft palate at midline and vice versa.
Uppercase and lowercase letters represent complete or incomplete defects, respectively.
In Winer JN, Verstraete FJM, Cissell DD, Lucero S, Athanasiou KA, Arzi B, “The application of 3-dimensional printing for
preoperative planning in oral and maxillofacial surgery in dogs and cats.”,
What were the most comon reasons for utilizing 3-D printing?
- Mandibular reconstruction (20/32) due to mandibulectomy (12) or fracture non union (6 dogs 2 cats)
- mapping osteotomy for TMJ ankylosis/pseudoankylosis (4)
- assessment of palatal defects (2)
- understanding complex anatomy for neoplasia (2 dogs 1 cat)
- understanding altered anatomy due to trauma (2 dogs)
In Doering S, Arzi B, Barich CR, Hatcher DC, Kass PH, Verstraete FJM, “Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of anatomic landmarks in small to medium-sized
brachycephalic dogs”,
What was the design of the study?
- retrospective
- 19 brachycephalic dogs with CBCT and dental rads
- evaluated visibility of 26 pre-defined landmarks in each of the CBCT modes and on dental rads
- Panoramic, 3-D mode and in MPR (slice by slice)
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
What was performed in this study?
Retrospective
Cohort of 19 brachycephalic dogs with dental disease
comparison of diagnostic ability 31 disorders in 10 categories:
dental radiographs Vs. 3 modes of CBCT (3D, Pano and Slices methodologies)
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
What was the design of this study?
24 cats,
28d study period with crossover, with cleaning between
dental diet versus no dental diet
compared QLF images with modified logan and boyce index
Evaluated intra-, inter- observer variability as well as effect of the diet.
In Fiani N, Verstraete FJM, Arzi B “Reconstruction of Congenital Nose, Cleft Primary Palate, and Lip Disorders”,
What is the most important factor in formation of primary clefts?
Genetics
(others are environmental teratogens, mystic emanations etc.)
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What was most common: Cleft lip (CL), cleft palate (CP) or both lip and palate (CLP)?
- Cleft palate 23/32
- Cleft lip (5/32)
- Cleft lip and palate (4/32)
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What was the goal of the study?
To apply a more accurate and detailed characterization system for palatal defects in dogs.
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What was the most common LAHSHAL type identified in cleft palate dogs?
HSH (21/23)
hSh (2/23)
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
Rank the following shapes of cleft palate defects from most to least common:
parallel, oval, pyriform, divergent
Pyriform (43%)
Parallel (22%)
Oval (17%)
Divergent (13%)
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What additional bone was deformed in most dogs in the study overall?
Vomer
CLP (100%)
CP (74%)
CL (20%)
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
What skull type appears to be predisposed to CL and CLP, but not to CP?
Brachycephalic -
80% of CL;
100 % of CLP
only 44% of CP - 56% mesaticephalic
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
Among CL and CLP defects, between which teeth did the alveolar defect usually reside?
what other 3 dental/maxillofacial defects were common?
Second and third incisors (100%)
Deviated permanent incisor teeth,
(persistent) deciduous incisor teeth,
Nonfused incisivomaxillary and vomeroincisive sutures
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
Which side was more commonly associated with cleft lip, and what is the proposed embryological reason?
- Left sided lip clefts more common, and this is also reported in humans
- Discrepancy in the laterality of lip and alveolus clefts is explained by differences in embryological events during palatogenesis - the left palatal shelf goes into a horizontal position later than the right, allowing a wider timeframe for abnormalities to occur
In Peralta S, Fiani N, Kan-Rohrer KH, Verstraete FJM, “Morphological evaluation of clefts of the lip, palate, or both in dogs”,
How many indvividual LAHSHAL classifications were found in this study?
What were the limitations of the LASHSAL system as applied to dogs?
9 LAHSHAL subtypes detected. 2 in CP, rest in CL and CLP cases
No accounting for severity
No accounting for shape of lesion
In Fiani N, Verstraete FJM, Arzi B “Reconstruction of Congenital Nose, Cleft Primary Palate, and Lip Disorders”,
What are 3 reasons to delay surgery until 4-6 months of age?
1 - more growth = more tissue to harvest for closure
2 - surgery will interfere with maxillorfacial growth more if performed when younger
- permanent teeth if unerupted my erupt and be malpositioned or interfere with repair when they do erupt
In Fiani N, Verstraete FJM, Arzi B “Reconstruction of Congenital Nose, Cleft Primary Palate, and Lip Disorders”,
What is the first phase of a staged approach and what are 2 reasons to opt to perform a staged procedure?
Phase 1 is selective dental extractions
Phase 2 is definitive repair
Reasons
- Minimal soft tissue available and extraction will allow harvest of more tissue
- Teeth are erupting into the cleft and will interfere with repair
In Fiani N, Verstraete FJM, Arzi B “Reconstruction of Congenital Nose, Cleft Primary Palate, and Lip Disorders”,
What is the most common complication and what are the purported reasons?
Dehiscence
- tension at the surgical site
- poor surgical technique
- occlusal interference (lower canine)
In Fiani N, Verstraete FJM, Arzi B “Reconstruction of Congenital Nose, Cleft Primary Palate, and Lip Disorders”,
In which order should the repair proceed?
- Repair of lip, nasal planum, rostral portion of floor of nose
- Repair of palatal defect
- Repair of floor of nose, gingival margin, alveolar and labial mucosa
- Repair of palatal defect
- Repair of floor of nose, gingival margin, alveolar and labial mucosa
- Repair of lip, nasal planum, rostral portion of floor of nose
Note - work central to peripheral - separating nose from mouth is the goal, and a cosmetic notch in the lip is acceptable.
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”,
How many stem cells were delivered, what was their source, and how many times were they given?
20 million
allogenic adipose derived stem cells from 3 SPF donor cats
given on day 0 and 1 month later (20 million per dose)
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”,
How were the stem cells tracked to ensure their target delivery to the oral cavity? What other tissues had high levels of detection, why?
ASCs were radiolabeled with Technetium and administered to three additional FCGS affected cats and one healthy SPF cat.
Whole body images taken with a gamma camera 1h, 6h, 24h after injection
Cat with FCGS had more uptake in oral cavity than controls
lungs - trapping of cells in capillary beds
kidney/bladder - filtration of dissociated radioisotope
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”,
What are 4 mechanisms by which stem cells cause immunomodulation?
- MSCs inhibit T-cell proliferation,
- alter B-cell function,
- downregulate MHC II on antigen-presenting cells
- inhibit dendritic cell maturation and differentiation
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
What histopathologic changes were seen in cats that responded versus cats that did not respond?
Upon completion of the study, a complete return to normal tissue architecture was observed in the biopsies of cats with complete clinical remission or substantial clinical improvement.
The biopsies from the cat with no clinical improvement were consistent with severe lymphoplasmacytic and neutrophilic ulcerative stomatitis prior to and after treatment
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
What differences were seen in results compared to the similar study using autologous stem cell therapy with respect to number improved, and time to cure?
- 4/7 responded in this study, 5/7 in the autologous study
- time to cure was ~12-20 months for this study versus 3-9 months for autologous study
*
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
Which cats were less likely to respond to ASC treatment?
cats with more severe systemic inflammation as measured by
- neutrophil count,
- interferon gamma
- globulin count
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
Which T-cell subset change was predictive of response to therapy in the autologous stem cell trial, but was not predictive of response in this allogenic trial?
CD8lo T-cells increasing to normal was predictive of response to therapy in autologous trial but not in the allogenic trial (this one)
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
What changes to T-Cell subsets are observed in cats affected by FCGS?
Increased CD8+ cells
Decreased CD8:CD4 ratio
Low CD8lo numbers
In Arzi, Clark, Sundaram et. al., “Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis”
What cytokine biomarker was identified in the autologous trial and what was found in this trial?
Were there other important cytokine differences?
IL-6 increased post treatment in the autologous trial but did not show the same alteration in this trial.
No consistent changes in TNFa, IL-6 or IFNy
In Winer JN, Verstraete FJM, Cissell DD, Lucero S, Athanasiou KA, Arzi B, “The application of 3-dimensional printing for
preoperative planning in oral and maxillofacial surgery in dogs and cats.”
When printing 3-d models what are the 2 broad types of material and their purpose?
- Build Material
create the desired geometry - this is the final product - Support material
sacrificial, helps to hold up overhangs and fill voids until manufacture complete.
high pressure water used to separate the support material afterwards.
In Winer JN, Verstraete FJM, Cissell DD, Lucero S, Athanasiou KA, Arzi B, “The application of 3-dimensional printing for
preoperative planning in oral and maxillofacial surgery in dogs and cats.”
What are 3 benefits of using custom printed 3-d models?
- improve preoperative planning and intraoperative guidance
- enrich veterinary student and resident training,
- facilitate client education and communication.
In Winer JN, Verstraete FJM, Cissell DD, Lucero S, Athanasiou KA, Arzi B, “The application of 3-dimensional printing for
preoperative planning in oral and maxillofacial surgery in dogs and cats.”
What is a major limitation of creating a 3-D printed skull?
Takes 18-24 hours to produce, therefore need 2 anesthetic events
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
What are 3 big advantages of using QLF over Logan and Boyce indices?
- Increased sensitivity - using continuous data not ordinal
- Ability to archive raw data in the form of images
- Predicted to detect an effect with one third of the number of cats
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
What key modification allowed detection of significantly more plaque with the QLF method?
application of a disclosing solution.
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
What was the proposed reason for decrease fluorescence of the plaque when undisclosed?
Differing bacterial communities may fluoresce more or less depending on their species composition.
unstudied in cats but mature communities fluoresce more red in humans.
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
What were the differences in plaque accumulation based on diet versus the control across both systems (i.e. QLF and Logan and Boyce)
QLF weighted mouth 14.24%
QLF average tooth 14.26%
Modified logan and boyce 14.64%
In Marshall-Jones ZV, Wallis CV, Allsopp JM, Colyer A, Davis IJ, Holcombe LJ “ Assessment of dental plaque coverage by Quantitative Light-induced Fluorescence (QLF) in domestic shorthaired cats”,
Which of the following is true with QLF:
- Inter-observer variability was high but intra-observer variability was low
- Inter-observer variability was low but intra-observer variability was high
- Inter-observer variability was low and intra-observer variability was low
- Inter-observer variability was high and intra-observer variability was high
Inter-observer variability was low and intra-observer variability was low
All variability was very low and correlated well with the logan and boyce method.
In Doering S, Arzi B, Barich CR, Hatcher DC, Kass PH, Verstraete FJM, “Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of anatomic landmarks in small to medium-sized
brachycephalic dogs”,
Which landmarks had NSD between CBCT and rads?
mandibular symphysis,
right and left mandibular canine teeth,
right and left mandibular first molar teeth,
right and left mandibular canals.
In Doering S, Arzi B, Barich CR, Hatcher DC, Kass PH, Verstraete FJM, “Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of anatomic landmarks in small to medium-sized
brachycephalic dogs”,
Rank from best to worst the Radiograph method, slices method, pano method and 3d method on their overall ability to identify anatomic landmarks.
- Slices (Overall mean score 2.77)
- 3D (Overall mean score 2.59)
- Radiograph (Overall mean score 1.68)
- Pano (overall mean score 1.65)
In Doering S, Arzi B, Barich CR, Hatcher DC, Kass PH, Verstraete FJM, “Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of anatomic landmarks in small to medium-sized
brachycephalic dogs”
Which Modality has the best resolution?
Dental radiographs
In Doering S, Arzi B, Barich CR, Hatcher DC, Kass PH, Verstraete FJM, “Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of anatomic landmarks in small to medium-sized
brachycephalic dogs”
Why did CBCT perform better than dental radiographs overall?
Unobstructed view was key to identifying landmarks in brachycephalic skull, more important than spatial resolution
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
What was the only category where the rad method had greater sensitivity (though not statistically significant?)
Loss of tooth integrity
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
What categories was the slices method significantly better than the Rad method for?
abnormal eruption
abnormally shaped roots
tooth resorption
and periodontitis
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
What percentage of periodontally affected teeth requiring extraction were missed by the Rad method, Pano method and the 3-D method respectively?
Rad method - 44%
Pano method - 41%
3D method - 20.5%
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
In which 5 categories did the slices method perform perfectly?
Missing teeth
abnormal eruption
abnormal number of roots
periodontitis
tooth resorption
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
In which 4 categories was combined CBCT modules significantly better than radiographs?
abnormal eruption,
abnormally shaped roots,
periodontitis,
tooth resorption
In Doering S, Arzi B, Hatcher DC, Kass PH, Verstraete FJM
“Evaluation of the diagnostic yield of dental radiography and cone-beam computed tomography for the identification of dental disorders in small to medium-sized brachycephalic dogs”,
Which CBCT method give the most detailed information?
The slices method
The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs J Vet Pharmacol Ther Linton, Wilson, Newbound What was the method of the study
Prospective study with 445 client owned dogs of various breeds randomly assigned a single dose of transdermal fentanyl applied 2-4 hours prior to surgery or buprenorphine IM 2-4 hours prir to surgery and every 6 hrs up to 90 hours post op
The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs J Vet Pharmacol Ther Linton, Wilson, Newbound What was the name of the pain scale used in the study?
Glasgow Composite Pain Scale
The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs J Vet Pharmacol Ther Linton, Wilson, Newbound Were adverse events attributed to either treatment?
Minimal adverse events and equal between groups
The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs J Vet Pharmacol Ther Linton, Wilson, Newbound What were the conclusions of the study?
Sustained plasma fentanyl concentrations provided by a single pre-emptive dose of TFS are safe and effective and are noninferior to repeated injections of buprenorphine in controlling postoperative pain over 4 days.
The influence of CBCT and periapical radiographic evaluation on the assessment of periapical bone destruction in dog’s teeth Oral Surg Oral Med Oral Pathol Oral Radiolog Endod Ordinola-Zapata, Bramante, Duarte et al. What was the aim of the study?
The determine the influence of periapical radiographs, CBCT section and CB volumetric data on the determination of periapical bone destruction in endodontically treated distal root canals of premolar canine teeth
The influence of CBCT and periapical radiographic evaluation on the assessment of periapical bone destruction in dog’s teeth Oral Surg Oral Med Oral Pathol Oral Radiolog Endod Ordinola-Zapata, Bramante, Duarte et al. What were used as controls in the study?
Nontreated mesial roots
The influence of CBCT and periapical radiographic evaluation on the assessment of periapical bone destruction in dog’s teeth Oral Surg Oral Med Oral Pathol Oral Radiolog Endod Ordinola-Zapata, Bramante, Duarte et al. What was the methodology of the study?
Eneerococcus faecalis was inoculated into 30 root canals of 2 mixed breed dogs to induce periodontitis After 60 days the root canals of the distal roots of the 11 mandibular and 4 maxillary premolars were endodontically treated (15 canals)
The influence of CBCT and periapical radiographic evaluation on the assessment of periapical bone destruction in dog’s teeth Oral Surg Oral Med Oral Pathol Oral Radiolog Endod Ordinola-Zapata, Bramante, Duarte et al. How was bone destruction evaluated?
5 evaluators used periapical radiographs and CBCT
The influence of CBCT and periapical radiographic evaluation on the assessment of periapical bone destruction in dog’s teeth Oral Surg Oral Med Oral Pathol Oral Radiolog Endod Ordinola-Zapata, Bramante, Duarte et al. What were the results of the study?
After 6 months periapical radiographs, coronal CBCT sections and volumetric data showed lower bone destruction in endodontically treated teeth in comparison with the control group The 5 evaluators found no differences between the apical periodontitis area of treated teeth and controls when CBCT section were used. No correlation was found between x-ray and CBCT volumetic values in treated root canals No relationship could be found between the periapical values of bone destruction and volumetic data found in CBCT of treated root canals
Occurrence and antimicrobial susceptibility of Porphyromonas spp and Fusobacterium spp. in dogs with and without periodontitis Anaerobe Senhorinho, Nakano, Liu Which bacteria found in subgingival plaque from dogs were evaluated in this study?
Porphyromonasgulae Pormonasmacacae Fusobacteriumnucleatum Fusobacteriumcanifelinum
Occurrence and antimicrobial susceptibility of Porphyromonas spp and Fusobacterium spp. in dogs with and without periodontitis Anaerobe Senhorinho, Nakano, Liu What was the method of the study?
50 dogs with periodontitis and 50 dogs without periodontitis were tested
Occurrence and antimicrobial susceptibility of Porphyromonas spp and Fusobacterium spp. in dogs with and without periodontitis Anaerobe Senhorinho, Nakano, Liu What were the results of the study in dogs with periodontitis?
With Periodontitis: 38 P. gulae 8 P. macacae 26 F. nucleatum 15 F. canifelinum
Occurrence and antimicrobial susceptibility of Porphyromonas spp and Fusobacterium spp. in dogs with and without periodontitis Anaerobe Senhorinho, Nakano, Liu What were the results of the study in dogs without periodontitis?
Without Peridontitis: 15 P.gulae 12 F. nucleatum 11 F. canifelinum
Occurrence and antimicrobial susceptibility of Porphyromonas spp and Fusobacterium spp. in dogs with and without periodontitis Anaerobe Senhorinho, Nakano, Liu Which strains were susceptible to the antibiotics tested?
All strains were susceptible to most of the antibiotics tested however different resistance rates to clarithromycin, erythromycin and metronidazole among strains were observed
Antimicrobial photodynamic therapy for the treatment of teeth with apical periodontitis: a histopathological evaluation J Endod Silva, Novaes, deOliveira What was the goal of the study?
The goal was to evaluate the in vivo response of apical and periapical tissues of dogs’ teeth with apical periodontitis after one-seesion endodontic treatment with and without antimicrobial photodynamic therapy
Antimicrobial photodynamic therapy for the treatment of teeth with apical periodontitis: a histopathological evaluation J Endod Silva, Novaes, deOliveira What was the methodology of the study?
60 root canals with experiementally induced apical periodontitits were instrumented and assigned into 4 groups receiving aPDT and root canal filling group 1 aPDT + RCF group 2 aPDT - RCF group 3 RCF - aPDT group 4 neither treatment Patients were killed and sections of maxilla and mandible taken and stained with H and E
Antimicrobial photodynamic therapy for the treatment of teeth with apical periodontitis: a histopathological evaluation J Endod Silva, Novaes, deOliveira What were the results?
In the aPDT treated groups the periapical region was moderately/severely enlarged with no inflammatory cells Moderate neoangiogenesis and fibrogenesis and the smallest periapical lesions Apical closure by mineralized tissue deposition was not achieved
Antimicrobial photodynamic therapy for the treatment of teeth with apical periodontitis: a histopathological evaluation J Endod Silva, Novaes, deOliveira What were the conclusions of the study?
aPDT can be a promising adjunct therapy to cleaning and shaping procedrues in teeth with apical periodontitis undergoing one-session endodontic treatment
The effect of Radachorin-Mediated Antimicrobial Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature Induced Periodontitis in Dogs J Periodontology Sorkhdini Moslemi, Jamshidi What was the aim of the study?
To evaluate the effect of adjunctive application of Radachlorin-mediated antibicrobial photodynamic therapy compared to scaling and root planning alone ofn clinical parameters and cytokine levels in gingival crevicular fluid of dogs with experimental periodontitis.
Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature Induced Periodontitis in Dogs J Periodontology Sorkhdini Moslemi, Jamshidi What were the materials and methods of the study?
Silk ligatures were placed around teeth to induce periodontal disease Four treatment groups 1 Radachlorin + diode laser 2 Radachlorin 3 Laser 4 No treatment
Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature Induced Periodontitis in Dogs J Periodontology Sorkhdini Moslemi, Jamshidi What were the results?
All treatment groups showed significant improvement in clinical and immunologic parameters No significant difference were found between the four groups
Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature Induced Periodontitis in Dogs J Periodontology Sorkhdini Moslemi, Jamshidi What was the conclusion?
Adjunctive use of Radachlorin-medicated aPDT has no additional effect on the clinical parameters or pro-inflammatory cytokine levels in ligature induced periodontitis
Autologous periodontal ligament cells in the treatment of class 3 furcation defects: a study in dogs J Clin Periodontolog Suaid, Ribeiro, Gomes What was the aim of the study?
To evaluate histomorphometrically the use of periodontal ligament cells in the treatment of class 3 furcation defects
Autologous periodontal ligament cells in the treatment of class 3 furcation defects: a study in dogs J Clin Periodontolog Suaid, Ribeiro, Gomes What was the methodology of the study?
4 treatment groups: 1 coronally positioned flap (control) 2 GTR group 3 Sponge group 4 Cell Group
Autologous periodontal ligament cells in the treatment of class 3 furcation defects: a study in dogs J Clin Periodontolog Suaid, Ribeiro, Gomes What were the results?
The cell group presented a superior length of new cementum, a greater extension of periodontal regeneration, and a larger area of new bone when compared to all other groups
Autologous periodontal ligament cells in the treatment of class 3 furcation defects: a study in dogs J Clin Periodontolog Suaid, Ribeiro, Gomes What were the conclusions of the study?
PDL cells in association with GTR may significantly promote periodontal regeneration in class 3 furcation defects surgically created in dogs
Clinical signs and histologic findings in dogs with odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What was the aim of the study?
To characterize clinical signs and histologic finding in dogs with odontogenic cysts and to determine wheter histologic findings were associated with clinical features
odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What were the results?
29 dentigerous cyst 1 radicular cyst 1 lateral periodontal cyst 1 gingival inclusion cyst 9 had possible odontogenic keratocysts
odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What are odontogenic keratoycysts?
9 dogs had clinical and histological features of keratocysts All of these cysts were located in the maxilla All of these cysts surrounded the roots of normally erupted teeth
odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What were the findings re: dentigerous cyts?
Of the 29 dogs with dentigerous cysts: 23 had single cysts 5 had 2 cysts 1 had 3 cysts 30 were associated with an unerupted first premolar 6 were associated with an unerupted canine tooth 1 cysts was associated with both
odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What breeds were overrepresented with dentigerous cysts?
Brachycephalic breeds
odontogenic cysts: 41 cases JAVMA Verstraete, Zin, Kass What is the proposed name for the odontogenic keratocysts?
Odontogenic parakertinized cysts Similar to cysts reported in humans
5-Lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats Am J Vet Res Wakshiag, Peters-kennedy, Bushey, Loftus What was the aim of the study?
To assess expression pattern and subcellular compartmentalization of 5-lipoxygenase in cutaneous, UV radiation induced and oral squamous cell carcinomas in cats To determine the effects of cyclooxygenarse or 5-lipoxygenase on proliferation or apoptosis in a feline oral squamous cell carcinoma cell line
5-Lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats Am J Vet Res Wakshiag, Peters-kennedy, Bushey, Loftus What was the methodology?
60 archieved samples for 60 cats Retrospective immunohistochemical analysis 20 cutaneous, 20 UV radiation-induced, and 20 oral tumors
Does removal of the original pulp tissue before autotransplantation influence ingrowth of new tissue in the pulp chamber? Dent Traumatology Laureys, Dermaut, Cuvelier What was the aim of the study?
To find out if revasculatization and ingrowth of new pulp tissue is influenced by removal of the original pulp tissue before autotransplantation
Does removal of the original pulp tissue before autotransplantation influence ingrowth of new tissue in the pulp chamber? Dent Traumatology Laureys, Dermaut, Cuvelier What was the methodology?
29 single rooted teeth from 2 adult beagle dogs were transplanted after resection of the root tip 15 teeth= had the pulp tissue removed before transplantation 14= had original pulp left in situ Histological exam of teeth 90 days post-transplantation
Does removal of the original pulp tissue before autotransplantation influence ingrowth of new tissue in the pulp chamber? Dent Traumatology Laureys, Dermaut, Cuvelier What were the results?
12/14 (80%) of teeth with tissue left in situ showed a pulp chamber with at least 1/3-2/3 filled with viable tissue 11/15 teeth (79%) with pulp tissue removed had no or little vital tissue in the pulp chamber
Does removal of the original pulp tissue before autotransplantation influence ingrowth of new tissue in the pulp chamber? Dent Traumatology Laureys, Dermaut, Cuvelier What were the conclusions?
Necrotic masses that develop in the original pulp tissue after transplation are a possible stimulating factor in the repair process of the pulp It is advisable to leave the pulp tissue in situ in autotransplanted teeth
Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis Pediatr Dent Lima, Esmeraldo What was the aim of the study?
To histologically evaluate the repair of rat tissue after pulpotomy and covering the pulp tissue with Copaifera oil resin, green propolis extract, fibrin sponge and iodoform-based paste
Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis Pediatr Dent Lima, Esmeraldo What was the methodology?
84 teeth in 21 rats received pulpotomies maxillary and mandibular first molars
Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis Pediatr Dent Lima, Esmeraldo What were the results?
Copaifera oil-resin group had the least inflammatory response Fibrin sponge group had the most inflammatory response and had microabscesses Copaifera oil-resin group had formation of mineralized tissue barrier in the pulp exposure area while all other groups did not
Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis Pediatr Dent Lima, Esmeraldo What were the conclusions?
The inflammatory response was less severe, the area of pulp necrosis was smaller and more frequent formation of a mineralized tissue barrier was noted after pulpotomy was performed with Copaifera oil-resin compared with other materials tested.
Lingual Arch Bar Application for Treatment of Rostral Mandibular Body Fractures in Cats Vet Surg Cetinkaya, Yardimci, Kaya What was the aim?
To describe a lingual arch bar technique for fixation of rostral mandibular body fractures and report outcome in 16 cats
Lingual Arch Bar Application for Treatment of Rostral Mandibular Body Fractures in Cats Vet Surg Cetinkaya, Yardimci, Kaya What was the study design?
Cats with rostral mandibular body fractures just caudal to the canine teeth 10 bilateral, 6 unilateral
Lingual Arch Bar Application for Treatment of Rostral Mandibular Body Fractures in Cats Vet Surg Cetinkaya, Yardimci, Kaya What were the methods?
Orthodontic wire was used as a lingual arch bar by contouring it to the shape of the lingual side of the alveolar margin and secured by circum-mandibular wires passed interproximal to the teeth
Lingual Arch Bar Application for Treatment of Rostral Mandibular Body Fractures in Cats Vet Surg Cetinkaya, Yardimci, Kaya What were the results?
11/16 cats could eat without a feeding tube within 24 hours Average time to fracture union was 42 days 5/16 cats had malocclusion however only 1 required correction…..(keep in mind this was a vet surgeon paper…….not a vet dentist paper!)
Presence of the oral bacterium Capnocytophaga canimorsus in the tooth plaque of canines Vet Microbial Dileege, Edgcomb, Leadbetter What was the methodology?
Samples of tooth plaque from 131 canines were collected, cultured and tested to help discern the presence of C. canimorsus
Presence of the oral bacterium Capnocytophaga canimorsus in the tooth plaque of canines Vet Microbial Dileege, Edgcomb, Leadbetter What were the results?
49.2% of canines sampled carried a species of Capnocytophaga 21.7% of canines sampled carried C. canimorsus A ndew species of Caphocytophaga may have been discovered in 16/131 dogs
Presence of the oral bacterium Capnocytophaga canimorsus in the tooth plaque of canines Vet Microbial Dileege, Edgcomb, Leadbetter What signalment was most likely to carry C. canimorsus?
male dogs and altered females and males (soooo like every dog except spayed females…) Small breed dogs most likely
Presence of the oral bacterium Capnocytophaga canimorsus in the tooth plaque of canines Vet Microbial Dileege, Edgcomb, Leadbetter What were 4 “human” species of Capnocytophaga found in 5 of the dogs?
C. ochracea C. haemolytica C. gingivalis C. granulosa
Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs Prev Vet Med Glickman, Glickman and Moore What was the methodology?
164000 dogs with periodontal disease compared to cohor of age-matched dogs with no periodontal disease from a national primary care practice (I suspect…Banfield…)
Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs Prev Vet Med Glickman, Glickman and Moore What were the results?
The hazard ration for azotemic CKD increased with increasing severity of periodontal disease Increasing severity of periodontal disease was also associated with serum creatinine >1.4 mg/dL and BUN >36 mg/dL independent of a veterinarian’s clinical diagnosis of CKD
Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs Prev Vet Med Glickman, Glickman and Moore What were the hazard ratios?
Stage 1 = 1.8 Stage 2= 2.0 Stage 3/4= 2.7
Evaluation of composite resin materials for maxillomandiubular fixation in cats for treatments of jaw fractures and temporomandibular joint luxations Vet Surg Hoffer, Manfra Marretta, Kurath What was the aim of the study?
To identify a method of composite application for MMF in cats that ensures the material will remain bonded during convalescence but be easy to remove with a low complication rate
Evaluation of composite resin materials for maxillomandiubular fixation in cats for treatments of jaw fractures and temporomandibular joint luxations Vet Surg Hoffer, Manfra Marretta, Kurath What was the study design?
88 Feline cadavers 22 cadavers in 4 groups CR= acid etch and composite resin CR+= acid etch, bonding agent, composite resin FR50= partial surface acid etch and flowable composite resin FR100= complete surface acid etch and flowable composite resin
Evaluation of composite resin materials for maxillomandiubular fixation in cats for treatments of jaw fractures and temporomandibular joint luxations Vet Surg Hoffer, Manfra Marretta, Kurath What were the results?
Load to failure results: FR50 and FR100 had higher load to failure results compared to CR and CR+ results FR100 had a higher removal time and was associated with more complication compared to the other 3 groups Most frequent complication during material removal in group FR 100 was crown fracture
Evaluation of composite resin materials for maxillomandiubular fixation in cats for treatments of jaw fractures and temporomandibular joint luxations Vet Surg Hoffer, Manfra Marretta, Kurath What were the conclusions?
Partial coronal surface acid etch before use of flowable composte maintained a strong bond yet resulted in easy material removal with low complication rate
Maxillomandibular external skeletal fixation in five cats with caudal jaw trauma J Small Animal Pract Moores What were the results of the case series?
3/5 cats were able to eat while 2/5 could not Fixation maintained for 21-42 days 5/5 cats were eating normally and had good jaw function at follow up
Orthodontic tooth movement in alveolar cleft repaired with a tissue engineering bone: An experimental study in dogs Tissue Eng Part A Zhang, Chu, Yang What was the aim of the study?
To investigate if a construct of porous B-tricalcium phosphate combined with osteogenically induced bone marrow stromal cells could repair alveolar cleft and allow for subsequent orthodontic tooth movement in a canine model
Orthodontic tooth movement in alveolar cleft repaired with a tissue engineering bone: An experimental study in dogs Tissue Eng Part A Zhang, Chu, Yang What was the methodology?
12 alveolar osteotomy surgiers in 6 dogs were made bilaterally and randomly implanted with 1.) tissue engineered bone complex, 2.) B-TCP alone 3,) autologous bone obtained from iliac bone Countralateral alveolar defects were created in one animal and left untreated to serve as blank control to observe spontaneous healing of the defects Orthodontic tooth movement was initiated 8 weeks after surgical operation for 12 weeks
Orthodontic tooth movement in alveolar cleft repaired with a tissue engineering bone: An experimental study in dogs Tissue Eng Part A Zhang, Chu, Yang What were the results?
Group A with tissue engineered bone complex dramatically promoted new bone formation and mineralization and achieved a favorable height of the repaired alveolar when compared to group B B-TCP alone The overall effect of the tissue engineered bone was equivalent to autologous bone ; the physiological function of the alveolar bone was restored by allowing the adjacent teeth to move into the newly formed bone in the grafted region
Orthodontic tooth movement in alveolar cleft repaired with a tissue engineering bone: An experimental study in dogs Tissue Eng Part A Zhang, Chu, Yang What were the conclusions?
The tissue engineering bone bone from the comfination of B-TCP and bMSC is a feasible clinical approach for patients with alveolar cleft and the subsequent orthodontic tooth movement
Molecular identification of bacteria associated with canine periodontal disease Vet Microbial Riggio, Lennon, Taylor What was the aim?
To identify the bacteria associated with canine gingivitis and periodontitis and to compare this with the normal oral flora
Molecular identification of bacteria associated with canine periodontal disease Vet Microbial Riggio, Lennon, Taylor What was the methodology?
Swabs were obtained from the gingival margin of 3 dogs with gingivitis and 3 oral healthy control and subgingival plaque was collected from 3 dogs with periodontitis Bacterial culture Culture-independent methods
Molecular identification of bacteria associated with canine periodontal disease Vet Microbial Riggio, Lennon, Taylor What were the results of the bacterial culture?
Top isolates normal group= uncultured bacterium 12.5% gingivitis group= Bacteroides heparinolyticus 10% periodontitis group= Actinomyces canis 20%
Molecular identification of bacteria associated with canine periodontal disease Vet Microbial Riggio, Lennon, Taylor What were the culture-independent results?
Top isolate normal group= Pseudomonas 30% gingivitis group= Porphyromonoas cangingivalis 16% periodontitis group= Desulfomicrobium orale 12%
Molecular identification of bacteria associated with canine periodontal disease Vet Microbial Riggio, Lennon, Taylor What were the overall results?
Uncultured species: normal group=13% gingivitis group=2% periodontitis group=10.5% Novel species: normal group=38% gingivitis group= 38% periodontitis group=35%
Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease Rawlinson, Goldstein, Reiter JAVMA What was the aim?
To determine whether severity of periodontal disease was associated with systemic health indices in dogs and whether treatment of PD altered systemic health indices
Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease JAVA Rawlinson, Goldstein, Reiter What was the design?
38 dogs received baseline testing of PE, serum biochem, CBC, UA, serum C-reactive protein and microalbuminuria tests prior to PD treatment and then again 4 weeks after treatment
Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease JAVA Rawlinson, Goldstein, Reiter What were the results?
Significant rank correlations were found between attachment loss and platelet number, creatinine concentration and before and after treatment results of CRP. BUN concentration were significantly higher after treatment than before treatment
Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease JAVA Rawlinson, Goldstein, Reiter What were the conclusions?
Increasing severity of attachment loss was associated with changes in systemic inflammatory variable and renal indices A decrease in CRP concentration after treatment was correlated with the severity of periodonitits The BUN concentration increased significantly after treatment.
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
What procedures were performed?
initially debridement, followed several months later by a pre-maxillectomy
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
Based on cultures, which antimicrobial was chosen and worked in this snake?
Trimethoprim Sulfa
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
Wanna see something cool?
Yup, thats a snake CT post-premaxillectomy. Look at their funky backfacing teeth and naturally disarticulated mandibles!!!
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
Wanna see something cool?
Yup, thats a snake CT post-premaxillectomy. Look at their funky backfacing teeth and naturally disarticulated mandibles!!!
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
Based on cultures, which antimicrobial was chosen and worked in this snake?
Trimethoprim Sulfa
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What are the compartments of the frontal sinus? which is the largest?
- caudal,
- rostral
- medial
caudal is the largest
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What structures fill most of the nasal cavity?
To what do the attach?
- The dorsal, ventral, and ethmoidal conchae fill most of the nasal cavity.
- The dorsal and ventral conchae attach on the ethmoid, nasal, and maxillary bones
- Ethmoidal conchae attach only to the ethmoid bones, which form the rostral aspect of the cranial vault
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which major artery supplies the nasal cavity?
Maxillary artery
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller artery supplies blood to the dorsal and ventral conchae?
Sphenopalatine
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller arteries supply blood to the hard palate?
most of the palate, and more rostrally the major palatine artery
caudally minor palatine artery
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller artery supplies blood to the Ethmoidal conchae?
internal ethmoidal arteries, coming through the cribriform plate
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which artery supplies blood to the soft tissues external to the nasal cavity?
Infraorbital
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which vein provides most of the external venous drainage?
facial vein
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which cranial nerve innervates most superficial muscles
Facial nerve
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What is this approach and what is it used to access?
Dorsal
Used to access access the nasal cavity and frontal sinuses.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What approach is this and what is it used access?
ventral approach
the preferred method to access the nasal cavity and nasopharyngeal region.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which cranial nerve and MAJOR BRANCH provides sensory innervation to the the nasal mucosa, roots of maxillary teeth?
CN - V - trigeminal - maxillary branch
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What is this approach and what is it used to access?
Dorsal
Used to access access the nasal cavity and frontal sinuses.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What approach is this and what is it used access?
ventral approach
the preferred method to access the nasal cavity and nasopharyngeal region.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What is the most common tumor of the nasal cavity?
Nasal adenocarcinoma
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What is the most common tumor of the nasal cavity?
Nasal adenocarcinoma
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which cranial nerve and MAJOR BRANCH provides sensory innervation to the the nasal mucosa, roots of maxillary teeth?
CN - V - trigeminal - maxillary branch
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733
What is the preferred approach for the caudal pharyngeal region?
What is important about this approach with regards to planning closure?
Approach through soft palate on midline. Leave caudal border intact to help facilitate closure with less risk of dehiscence.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733
Which approach allows the best visualization of the rostral nasal septum region?
The combined rostrolateral rhinotomy approach
Gao W, Chan Y, You M, Lacap-Bugler DC, Leung WK, Watt RM. In-depth snapshot of the equine subgingival microbiome. Microbial Pathogenesis. 2016;94(C):76-89.
SKIP
There are bacteria in the equine mouth including spirochaetes and treponema. The end.
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
How many published articles met the criteria for inclusion in the study?
16
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was methodology and what were were criteria for inclusion in the study?
- Found in PUBMED, CAB abstracts, Web of Science - search string [(cat OR cats OR feline OR felines) AND (stomatitis OR gingivostomatitis) AND (treatment)]
- Published in English and
- Peer reviewed journal
- spontaneous FCGS and original data (not a recapitulation without new data)
- clearly defined treatment protocol.
- Not as a sequela to other disease for which treatment was aimed (FIV/FeLV)
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the key part of evidence grade A, B and C?
How many studies achieved each grade?
A - Histo
B - semi-quantitative scoring system +/- subjective and owner info
C - subjective and owner info without a semi-quantitative system
A- 2 studies
B - 7 studies
C - 7 studies
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What were the criteria for evidence design grade 1-5?
how many of each study were there?
1 - randomized double blinded prospective clinical trial - 4 studies
2 - prospective clinical trial +/- control group - 3 Studies
3 - retrospective case series N>10 - 3 studies
4 - retrospective case series N<10 - 1 study
5 - case reports, expert opinions - 5 studies
4
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the breakdown of medical versus surgical studies?
10 medical
6 surgical
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for local paramunization, thalidomide, lactoferrin, cyclosporine, recombinant feline interferon omega, and autologous mesenchymal stem cells?
elicit immunomodulatory effects
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA of Prednisolone and piroxicam
reduce inflammation
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Recombinant feline interferon omega?
Impedes viral replication
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for lactoferrin?
inhibits bacterial growth
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for dietary change?
accelerates healing and reduces inflammation
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Dental extractions
reduce immune stimulation via eliminating plaque
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Zincreo germicidal astringent obtundent
not reported
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the problem created with control groups rendering study:study comparison pointless?
Each study used a different control treatment, NSAID, Steroid, diet etc.
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the problem with scoring systems that rendered study:study comparison difficult?
- 4 articles created a novel custom scoring system
- 3 modelled a new system off an existing one
- 2 used the same scoring system
- Some used body weight or owners perceptions
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was the methodology?
38 horses, assigned a malocclusion score, half treated and half not treated.
all ridden twice before and 3 times after treatment or non-treatment by the same professional rider.
assigned a rideability score
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was found?
pre treatment score and treatment versus non treatment had no impact on rideability score.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What was done in the study?
Ten New Zealand white rabbit cadaver heads were scanned using CBCT and conventional CT.
The visibility of relevant dental and anatomic features (pulp cavity, germinal center, tooth outline, periodontal ligament) were scored and compared between conventional CT and CBCT.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What was found in the study?
In general, it was found that CBCT was superior to conventional CT when imaging the dentition. Importantly, the periodontal ligament was significantly (P < 0.01) more visible on CBCT than on conventional CT.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What were the conclusions of the study?
Ability to see the periodontal ligament with such detail may allow earlier detection and treatment of periodontal disease in rabbits.
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What was done in the study?
•A total of 15 client-owned rabbits had CBCT, oral examination, dental charting, and dental treatment performed under general anesthesia.
Images were evaluated using transverse and custom multiplanar (MPR), 3D, and panoramic reconstructed images.
The CBCT findings were grouped into abnormalities that could be detected on conscious oral examination vs. abnormalities that could not be detected by conscious oral examination.
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What were the most common CBCT findings?
- periodontal ligament space widening (14/15),
- premolar and molar malocclusion (13/15),
- apical elongation (13/15),
- coronal elongation (12/15),
- inflammatory tooth resorption (12/15),
- periapical lucency (11/15),
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What was the oral exam finding and CBCT finding that were associated?
Coronal elongation on oral exam associated with apical elongation on CBCT
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was the aim of the study?
To determine if:
(1) if degree of dental malocclusion assigned prior to dental treatment was associated with equine rideability, assessed using a standardized score and
(2) if performance dentistry improved this score.
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What were the author’s recommendations for future FCGS research?
- Histopathology
- Use control groups and allow pain medication but no other treatment
- Switch control groups to test groups after a period of time (if failed)
- Test new treatments and stop repeating the same studies!
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What are the major problems with FCGS research thus far (4)?
- Most studies use different scoring systems
- No standardized control therapy
- May studies single case reports
- Many studies didn’t meet inclusion criteria
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733
Which approach allows the best visualization of the rostral nasal septum region?
The combined rostrolateral rhinotomy approach
Gao W, Chan Y, You M, Lacap-Bugler DC, Leung WK, Watt RM. In-depth snapshot of the equine subgingival microbiome. Microbial Pathogenesis. 2016;94(C):76-89.
SKIP
There are bacteria in the equine mouth including spirochaetes and treponema. The end.
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
How many published articles met the criteria for inclusion in the study?
16
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was methodology and what were were criteria for inclusion in the study?
- Found in PUBMED, CAB abstracts, Web of Science - search string [(cat OR cats OR feline OR felines) AND (stomatitis OR gingivostomatitis) AND (treatment)]
- Published in English and
- Peer reviewed journal
- spontaneous FCGS and original data (not a recapitulation without new data)
- clearly defined treatment protocol.
- Not as a sequela to other disease for which treatment was aimed (FIV/FeLV)
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the key part of evidence grade A, B and C?
How many studies achieved each grade?
A - Histo
B - semi-quantitative scoring system +/- subjective and owner info
C - subjective and owner info without a semi-quantitative system
A- 2 studies
B - 7 studies
C - 7 studies
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What were the criteria for evidence design grade 1-5?
how many of each study were there?
1 - randomized double blinded prospective clinical trial - 4 studies
2 - prospective clinical trial +/- control group - 3 Studies
3 - retrospective case series N>10 - 3 studies
4 - retrospective case series N<10 - 1 study
5 - case reports, expert opinions - 5 studies
4
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the breakdown of medical versus surgical studies?
10 medical
6 surgical
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for local paramunization, thalidomide, lactoferrin, cyclosporine, recombinant feline interferon omega, and autologous mesenchymal stem cells?
elicit immunomodulatory effects
In Winer JN, Arzi B, Verstraete FJM. Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA of Prednisolone and piroxicam
reduce inflammation
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Recombinant feline interferon omega?
Impedes viral replication
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What was the oral exam finding and CBCT finding that were associated?
Coronal elongation on oral exam associated with apical elongation on CBCT
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What were the most common CBCT findings?
- periodontal ligament space widening (14/15),
- premolar and molar malocclusion (13/15),
- apical elongation (13/15),
- coronal elongation (12/15),
- inflammatory tooth resorption (12/15),
- periapical lucency (11/15),
In Riggs GG, Cissell DD, Arzi B, et al. Clinical Application of Cone Beam Computed Tomography of the Rabbit Head: Part 2-Dental Disease. Frontiers in veterinary science. 2017;4:5.
What was done in the study?
•A total of 15 client-owned rabbits had CBCT, oral examination, dental charting, and dental treatment performed under general anesthesia.
Images were evaluated using transverse and custom multiplanar (MPR), 3D, and panoramic reconstructed images.
The CBCT findings were grouped into abnormalities that could be detected on conscious oral examination vs. abnormalities that could not be detected by conscious oral examination.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What were the conclusions of the study?
Ability to see the periodontal ligament with such detail may allow earlier detection and treatment of periodontal disease in rabbits.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What was found in the study?
In general, it was found that CBCT was superior to conventional CT when imaging the dentition. Importantly, the periodontal ligament was significantly (P < 0.01) more visible on CBCT than on conventional CT.
In Riggs GG, Arzi B, Cissell DD, et al. Clinical Application of Cone-Beam Computed Tomography of the Rabbit Head: Part 1 - Normal Dentition. Frontiers in veterinary science. 2016;3:93.
What was done in the study?
Ten New Zealand white rabbit cadaver heads were scanned using CBCT and conventional CT.
The visibility of relevant dental and anatomic features (pulp cavity, germinal center, tooth outline, periodontal ligament) were scored and compared between conventional CT and CBCT.
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was found?
pre treatment score and treatment versus non treatment had no impact on rideability score.
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was the methodology?
38 horses, assigned a malocclusion score, half treated and half not treated.
all ridden twice before and 3 times after treatment or non-treatment by the same professional rider.
assigned a rideability score
In Moine S, Flammer SA, De Jesus Maia-Nussbaumer P, Klopfenstein Bregger MD, Gerber V. Evaluation of the effects of performance dentistry on equine rideability: a randomized, blinded, controlled trial. Veterinary Quarterly. 2017;37(1):195-199.
What was the aim of the study?
To determine if:
(1) if degree of dental malocclusion assigned prior to dental treatment was associated with equine rideability, assessed using a standardized score and
(2) if performance dentistry improved this score.
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What were the author’s recommendations for future FCGS research?
- Histopathology
- Use control groups and allow pain medication but no other treatment
- Switch control groups to test groups after a period of time (if failed)
- Test new treatments and stop repeating the same studies!
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What are the major problems with FCGS research thus far (4)?
- Most studies use different scoring systems
- No standardized control therapy
- May studies single case reports
- Many studies didn’t meet inclusion criteria
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the problem with scoring systems that rendered study:study comparison difficult?
- 4 articles created a novel custom scoring system
- 3 modelled a new system off an existing one
- 2 used the same scoring system
- Some used body weight or owners perceptions
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What was the problem created with control groups rendering study:study comparison pointless?
Each study used a different control treatment, NSAID, Steroid, diet etc.
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Zincreo germicidal astringent obtundent
not reported
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for Dental extractions
reduce immune stimulation via eliminating plaque
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for dietary change?
accelerates healing and reduces inflammation
In Winer JN, Arzi B, Verstraete FJM.
Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Frontiers in veterinary science. 2016;3:54.
What is the reported MOA for lactoferrin?
inhibits bacterial growth
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733
What is the preferred approach for the caudal pharyngeal region?
What is important about this approach with regards to planning closure?
Approach through soft palate on midline. Leave caudal border intact to help facilitate closure with less risk of dehiscence.
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which cranial nerve innervates most superficial muscles
Facial nerve
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which vein provides most of the external venous drainage?
facial vein
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which artery supplies blood to the soft tissues external to the nasal cavity?
Infraorbital
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller artery supplies blood to the Ethmoidal conchae?
internal ethmoidal arteries, coming through the cribriform plate
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller arteries supply blood to the hard palate?
most of the palate, and more rostrally the major palatine artery
caudally minor palatine artery
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which smaller artery supplies blood to the dorsal and ventral conchae?
Sphenopalatine
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
Which major artery supplies the nasal cavity?
Maxillary artery
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What structures fill most of the nasal cavity?
To what do the attach?
- The dorsal, ventral, and ethmoidal conchae fill most of the nasal cavity.
- The dorsal and ventral conchae attach on the ethmoid, nasal, and maxillary bones
- Ethmoidal conchae attach only to the ethmoid bones, which form the rostral aspect of the cranial vault
In Weeden AM, Degner DA. Surgical Approaches to the Nasal Cavity and Sinuses. Veterinary Clinics of North America: Small Animal Practice. 2016;46(4):719-733.
What are the compartments of the frontal sinus? which is the largest?
- caudal,
- rostral
- medial
caudal is the largest
In “Latney LTV, McDermott C, Scott G, et al. Surgical management of maxillary and premaxillary osteomyelitis in a reticulated python (Python reticulatus). Journal of the American Veterinary Medical Association. 2016;248(9):1027.
What procedures were performed?
initially debridement, followed several months later by a pre-maxillectomy
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
Which breeds were most commonly affected?
Cocker spaniels and scottish terriers (7/14 dogs)
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
What were the most common clinical sign?
What (counterintuitive) sign did no dogs present with?
Halitosis (14/14)
Mandibular lymphadenopathy (11/14)
oral pain (9/14)
imappetance/difficulty eating (6/14)
NO DOG HAD A FEVER
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
What was the most common historical finding in affected dogs?
Recent dental extractions (63.3% of cases)
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
What were exclusion criteria?
neoplasia, electric burns and radiation therapy
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
What was the ratio of maxilla to mandible?
60% in the maxilla, 40% in the mandible
According to Peralta S, Arzi B, Nemec A, in Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014),
Which radiograph would be an accurate representation of the amount of pathology?
Mandibular rad.
maxillary rads don’t correlate well with CT or surgical explorational extent of disease.
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
Hown many patients and sites were found over the 25 years?
13 patients, 15 sites
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
How many sites were considered secondary to dental extraction?
3
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
What is the difference in this paper between ONJ and ORNJ?
Osteonecrosis of the jaw was considered with tumor recurrence (5 cases)
osteoradionecrosis of the jaw was considered when there was no tumor recurrence
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
Relative to the target field, where were lesions located and how many?
8 in the radiation region
4 in an adjacent area of tissue
1 in the contralateral mandible
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
What was the time to onset from treatment
Range
median
mean
Range 2-44 months
median 9.8 months
mean 12.4 months
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
Below what dose of radiation is the risk considered low in people?
60 Gy
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
What are other identified risk factors in people?
- Co-60 RT,
- high total doses,
- short regimens with higher dose/fraction,
- large field size
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
What imaging modality would be the most likely to correlate well with true findings in this lesion?
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
Assuming there has been no tumor recurrence in this lesion found in a previously irradiated field,
When performing surgical debridement of this lesion, what signs would tell you that debridement is complete?
Normal appearing bone that bleeds readily.
According to Nemec A, Arzi B, Hansen K, et al. in Osteonecrosis of the Jaws in Dogs in Previously Irradiated Fields: 13 Cases (1989-2014).
What factors are associated with lower risk?
- megavoltage RT (higher energy than orthovoltage)
- continuous hyperfractionated (more smaller fractions with less down time between)
- corticosteroid use during treatment
According to Soukup JW, Snyder CJ. in Traumatic Dentoalveolar and Maxillofacial Injuries in Cats: Overview of diagnosis and management,
What is the most common TDI in cats?
Enamel-dentin-pulp fracture
According to Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW. in
Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs,
What 2 shapes were the best approximation?
Right elliptical frustrum (cone with amputated tip)
Right elliptical cone
Soukup JW, Snyder CJ. Traumatic Dentoalveolar and Maxillofacial Injuries in Cats: Overview of diagnosis and management
How prevalent are TDI’s in HEALTHY patients?
27% of healthy cats and dogs have a TDI
Soukup JW, Snyder CJ. Traumatic Dentoalveolar and Maxillofacial Injuries in Cats: Overview of diagnosis and management
How prevalent are TDIs in cases of maxillofacial trauma?
72% of cases have a TDI
According to Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW. in
Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs,
What was performed in this study?
Measured dies from crowns with a laser scanner to evaluate surface area, and then used physical measurements to create a mathematical model to predict a crown pre’s surface area.
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
Which lines in the photo below represent overbite and overjet? Describe the difference.
AB Overjet
CD overbite
overjet is how far the labial surface is rostral to where it should be (i.e. in line with labial surface of the mandibular incisors.)
Overbite is how far the occlusal surface is from where it should be (i.e. occluding with the mandibular incisors)
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
What was done in this study?
restrospective looking at correction of MAL2 in foals using a device like this. orthodontic wires and an incline plane
According to Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW. in
Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs,
Why do the not recommend using the best models chairside in clinical practice?
require laser scanning (elliptical frustrum) and complicated computer software mathematics
According to Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW. in
Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs,
What is the recommended model to use in clinical practice, why?
Circular cone - only requires 2 measurements and simple equation
need major base diameter and height
According to Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW. in
Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs,
What other 2 shapes provided an accurate estimate, and what is the drawback to using them chairside?
Right pyramidal cone and circular frustrum
both need 3 measurements and equations are more difficult.
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
What surgical and post op complications were seen?
surgical - bleeding major palatine arteries
post-op - device hurt mare’s udder
permanent incisors abnormal eruption in 7
valve diastema between maxillary 07’s and 08’s in ALL foals
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
in what proportion of overbites and overjets did treatment reduce the malocclusion?
Overjet 95%
Overbite 90%
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
What proportion of foals had a complete reduction of overjet and what proportion had a reduction to <5mm overjet?
25% complete reduction
51% to <5mm (functionally corrected)
According to Easley J, Dixon PM, Reardon RJ. Orthodontic correction of overjet/overbite (‘parrot mouth’) in 73 foals (1999-2013)
What factors had a positive impact on treatment?
starting at an early age
increased severity at diagnosis had a positive association with rate of correction
According to Heidenreich D, Gradner G, Kneissl S, Dupre G. Nasopharyngeal Dimensions From Computed Tomography of Pugs and French Bulldogs With Brachycephalic Airway Syndrome.
Which breed had the smaller airway?
The pug
According to Heidenreich D, Gradner G, Kneissl S, Dupre G. Nasopharyngeal Dimensions From Computed Tomography of Pugs and French Bulldogs With Brachycephalic Airway Syndrome.
In what location was the airway the smallest?
Dorsal to the caudal end of the soft palate
According to Heidenreich D, Gradner G, Kneissl S, Dupre G. Nasopharyngeal Dimensions From Computed Tomography of Pugs and French Bulldogs With Brachycephalic Airway Syndrome.
Which breed has the larger and thicker soft palate?
french bulldog
According to Suske A, Poschke A, Schrock P, Kirschner S, Brockmann M, Staszyk C.
Infundibula of equine maxillary cheek teeth. Part 1: Development, blood supply and infundibular cementogenesis.
Why is the mesial infundibulum more prone to incomplete cementogenesis?
central artery supplying bloodflow for genetation of cementum is destroyed at eruption. lateral arteries located more coronally, and destroyed soon after eruption for mesial infundibulum, wheras the distal infundibulum has a more apically located artery which persists for longer after eruption.
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
What was performed in this study?
- harvested fat from 9 cats with non responsive FCGS.
- grew mesenchymal stem cells from them and injected them IV back into the cats.
- repeated injection after 1 month
- 20 million stem cells per injection
measured response to treatment via blood markers, histopath and a clinical scorinng system
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
what T cell changes are seen in cats with stomatitis?
High CD8+ cells and a low CD4:CD8 ratio
According to Chinkangsadarn T, Wilson GJ, Greer RM, Pollitt CC, Bird PS. in
An abattoir survey of equine dental abnormalities in Queensland, Australia,
Identify the equine abnormality in b (arrows and star), c and d.
a. normal
b. hook and sharp enamel points
c step
d. diastemata and periodontal pockets.
N.B. Wave mouth not shown
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
What are the immunomodulatory mechanisms of mesenchymal stem cells?
- MSCs inhibit T-cell proliferation,
- alter B-cell function,
- downregulate MHC II on antigen-presenting cells,
- inhibit dendritic cell maturation and differentiation
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
what cytokine change was seen in cats that responded?
increase in serum IL-6
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
what proportion of cats had a cure or significant improvement?
5/7 or 71%
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
What T cell change was predictive of response to therapy?
low percentage of CD8+ lo cells predicted response to therapy
According to Arzi et al. in Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats,
Succesful ASC treatment resulted in what 5 outcomes?
- (a) complete clinical remission or reduction in clinical disease severity,
- (b) histologic resolution of the oral lesions,
- (c) reduction of total circulating CD8+ T cells (and increased CD8lo cells),
- (d) resolution of neutrophilia and reduction of serum proinflammatory cytokine concentrations (IL-1b and IFN-g), and
- (e) increases in serum IL-6 levels.
According to Chinkangsadarn T, Wilson GJ, Greer RM, Pollitt CC, Bird PS. in
An abattoir survey of equine dental abnormalities in Queensland, Australia,
What were the 4 most common abnormalities identified, in order of prevalence?
Sharp enamel points
Hooks
Wave mouth
periodontal pockets
Schwabenlander M, Stepaniuk K, Carstensen M, Armien AG.
Brain, Craniofacial, and Dental Lesions of a Free-ranging Gray Wolf (Canis lupus) Implicated in a Human Attack in Minnesota, USA.
•A wolf implicated in a human attack had a messed up skull, dentition and brain.
According to Carreira LM, Dias D, Azevedo P. in
Relationship Between Gender, Age, and Weight and the Serum Ionized Calcium Variations in Dog Periodontal Disease Evolution,
What correlations were found between age, PD Dz and iCa?
As age increase,
PD Dz increases
ionized calcium decreases
According to Miguel Carreira L, Daniela D, Pedro A. in
Serum Ionized Calcium Quantification for Staging Canine Periodontal Disease: A Preliminary Study
What was found with regards to serum iCa and PdDz.
how does it compare to the other study by the same authors?
ionized calcium goes up with worsening PdDz.
exactly opposite to other study by the same authors, which says it goes down as animals age and as PDDz gets worse.
According to Lohinai Z, Keremi B, Szoko E, et al. in
Biofilm Lysine Decarboxylase, a New Therapeutic Target for Periodontal Inflammation,
What is tranexaminic acid (TA) and What was the main problem with the TA mouthwash?
TA is an analog of lysine. inhibits biofilm formation
also inhibits attachment of gingival epithelial cells
According to Santos M, Carreira LM. in
Mathematical equation for prediction of cat mandibular canal height dimension based on canine tooth width measurement,
Which of the following measurements was correlated with canine tooth width?
what was the margin of error?
Height of the mandibular canal.
margin of error was 0.4 mm
According to Carvalho CM, Rahal SC, Mesquita L, Castilho MS, Kano W, Mamprim M. in
Mandibulectomy for treatment of fractures associated with severe periodontal disease,
What was the most common location for fracture in this case series?
ROSTRAL to M1
According to Losinski SL, Stanley BJ, Schallberger SP, Nelson LL, Millard HAMT. in
Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction,
what is being shown here?
transillumination of the flap to ensure incorporation of AO artery.
According to Carvalho CM, Rahal SC, Mesquita L, Castilho MS, Kano W, Mamprim M. in
Mandibulectomy for treatment of fractures associated with severe periodontal disease,
How many bilateral and how many unilateral fractures were there?
4 bilateral, 2 unilateral
According to Losinski SL, Stanley BJ, Schallberger SP, Nelson LL, Millard HAMT. in
Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction,
the plane of dissection should be deep to which muscles?
In which direction is dissection performed?
deep to the platysma and the sphincter colli profundus
dissect caudal to rostral
According to Losinski SL, Stanley BJ, Schallberger SP, Nelson LL, Millard HAMT. in
Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction,
what was the rate of dehiscence, what was the stated reason for this?
3/9 flaps dehisced at the distal edge.
thought they had extended flap beyond where the blood supply would reach
According to Losinski SL, Stanley BJ, Schallberger SP, Nelson LL, Millard HAMT. in
Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction
what was the most common flap complication?
mild(3/9) or moderate (5/9) flap edema
According to Losinski SL, Stanley BJ, Schallberger SP, Nelson LL, Millard HAMT. in
Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction,
What are the landmarks for the flap incisions?
dorsal border of the flap: incision along the ventral aspect of the zygomatic arch, extending caudally to either just beyond the vertical ear canal or to the wing of the atlas, depending on the desired length of the flap
The ventral border of the flap was created with a parallel incision at the level of the horizontal ramus of the mandible, and the caudal border of the flap was created by joining these ventral and dorsal incisions.
Accoding to Snyder CJ, Soukup JW, Drees R, Tabone TJ. in
Caudal Mandibular Bone Height and Buccal Cortical Bone Thickness Measured by Computed Tomography in Healthy Dogs
What was the study design?
retrospective looking at CT’s of healthy mandibles and measuring cortical bone thickness at various locations
split into groups based on weight
Accoding to Snyder CJ, Soukup JW, Drees R, Tabone TJ. in
Caudal Mandibular Bone Height and Buccal Cortical Bone Thickness Measured by Computed Tomography in Healthy Dogs,
Why were they looking for 2mm of thickness?
need 2mm of thickness of cortical bone to generate compression with plate fixation and monocortical screws