Cancer studies Flashcards
Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.
What proportion were MM? What proportion were SCC?
MM 30%
SCC32%
Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.
What was the MST for lingual MM? What was the MST for lingual SCC?
MM - 241 days
SCC - 216 days
Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.
What was the overall MST?
483 days
Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.
What prognostic factor was identified that held true on multivariate analysis?
•Dogs with lingual tumors >2cm in diameter at diagnosis had a significantly shorter survival time than did dogs with tumors < 2 cm
(univariate also had significant values for placement of feeding tube (negative) and dogs that developed metastases (negative))
Size was only one that held up.
Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.
What was the largest factor identified in this study regarding survival?
surgery or no surgery
Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.
What was the MST for dogs having no surgery?
54 days
Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.
What other factors were identified that impacted overall survival? (aside from surgery or no surgery)
Tumor associated inflammation (more was worse)
Risk score (combined tumor associated inflammation with perineural invasion and with lymphovascular inflammation)
Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.
Which factors were NOT associated with survival?
Tumor location,
clinical stage
histologic subtype
Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.
What were the MST in dogs and cats respectively?
MST 550 days in dogs, MST 516 in cats
Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.
What were the proportions of parotid and mandibular gland tumors in the dog and cat?
Dog 50% parotid, 30% mandibular
Cat 60% Mandibular, 20% parotid
Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.
What breeds were over represented?
Cats - siamese & crosses
Dogs - no breed predisposition
Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.
What prognostic factors were identified in the dog?
Stage I and II tumor versus either stage III or stage IV
Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.
What was the most common histopathologic tumor type?
simple adenocarcinoma
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
what proportion were completely and incompletely excised?
73% clean margins, 27% incomplete excision
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
What were the overall median progression free interval and the median survival time?
Were they longer or shorter than previously reported?
PFI 508 days
MST 723 days
Longer
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
In the multivariate analysis, what factors had negative prognostic influence?
Did they influence survival or progression?
metastases at diagnosis hazard ratio 3.8 for death
treated with surgery AND adjuvant hazard ratio 2.3 for progression
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
How many dogs diagnosed with well differentiated melanoma died of their disease?
none
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
What was to proposed reason for why dogs receiving adjuvant therapy did worse?
selection bias - adjuvant therapy recommended more for worse cases
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
What differences were seen in outcome based on intraoral location?
none
Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.
What were the Median survival time and progression free interval for dogs that had only surgery?
PFI >567d (median not reached)
MST 874 days
What proportion of all tumors are oral tumors?
5-7%
Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.
What were the most important prognostic factors associated with survival for oral tumors with curative intent resection?
tumour type
completeness of excision,
tumour size
age.
Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.
What were the shortest MST’s in this study?
MM 206 days
OSA 209 days
Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.
which tumor had the highest local recurrence rate?
Fibrosarcoma 54%
Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.
What tumor had the highest distant metastatic rate?
MM - 30%
Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.
What was the overall rate of clean margins with 2 cm surgical planning?
85%