Cancer studies Flashcards

1
Q

Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.

What proportion were MM? What proportion were SCC?

A

MM 30%

SCC32%

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2
Q

Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.

What was the MST for lingual MM? What was the MST for lingual SCC?

A

MM - 241 days

SCC - 216 days

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3
Q

Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.

What was the overall MST?

A

483 days

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4
Q

Culp WTN, Ehrhart N, Withrow SJ, et al.
Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases(1995-2008). Journal of the American Veterinary Medical Association. 2013;242(10):1392.

What prognostic factor was identified that held true on multivariate analysis?

A

•Dogs with lingual tumors >2cm in diameter at diagnosis had a significantly shorter survival time than did dogs with tumors < 2 cm

(univariate also had significant values for placement of feeding tube (negative) and dogs that developed metastases (negative))

Size was only one that held up.

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5
Q

Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.

What was the largest factor identified in this study regarding survival?

A

surgery or no surgery

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6
Q

Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.

What was the MST for dogs having no surgery?

A

54 days

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7
Q

Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.

What other factors were identified that impacted overall survival? (aside from surgery or no surgery)

A

Tumor associated inflammation (more was worse)

Risk score (combined tumor associated inflammation with perineural invasion and with lymphovascular inflammation)

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8
Q

Fulton AJ, Nemec A, Murphy BG, Kass PH, Verstraete FJM. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010). Journal of the American Veterinary Medical Association. 2013;243(5):696.

Which factors were NOT associated with survival?

A

Tumor location,
clinical stage
histologic subtype

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9
Q

Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.

What were the MST in dogs and cats respectively?

A

MST 550 days in dogs, MST 516 in cats

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10
Q

Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.

What were the proportions of parotid and mandibular gland tumors in the dog and cat?

A

Dog 50% parotid, 30% mandibular

Cat 60% Mandibular, 20% parotid

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11
Q

Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.

What breeds were over represented?

A

Cats - siamese & crosses

Dogs - no breed predisposition

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12
Q

Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.

What prognostic factors were identified in the dog?

A

Stage I and II tumor versus either stage III or stage IV

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13
Q

Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth W.

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. Journal of the American Animal Hospital Association. 2001;37(5):478-482.

What was the most common histopathologic tumor type?

A

simple adenocarcinoma

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14
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

what proportion were completely and incompletely excised?

A

73% clean margins, 27% incomplete excision

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15
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

What were the overall median progression free interval and the median survival time?

Were they longer or shorter than previously reported?

A

PFI 508 days

MST 723 days

Longer

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16
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

In the multivariate analysis, what factors had negative prognostic influence?

Did they influence survival or progression?

A

metastases at diagnosis hazard ratio 3.8 for death

treated with surgery AND adjuvant hazard ratio 2.3 for progression

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17
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

How many dogs diagnosed with well differentiated melanoma died of their disease?

A

none

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18
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

What was to proposed reason for why dogs receiving adjuvant therapy did worse?

A

selection bias - adjuvant therapy recommended more for worse cases

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19
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

What differences were seen in outcome based on intraoral location?

A

none

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20
Q

Tuohy JL, Selmic LE, Worley DR, Ehrhart NP, Withrow SJ.
Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association. 2014;245(11):1266.

What were the Median survival time and progression free interval for dogs that had only surgery?

A

PFI >567d (median not reached)

MST 874 days

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21
Q

What proportion of all tumors are oral tumors?

A

5-7%

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22
Q

Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.

What were the most important prognostic factors associated with survival for oral tumors with curative intent resection?

A

tumour type
completeness of excision,
tumour size
age.

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23
Q

Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.

What were the shortest MST’s in this study?

A

MM 206 days

OSA 209 days

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24
Q

Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.

which tumor had the highest local recurrence rate?

A

Fibrosarcoma 54%

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25
Q

Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.

What tumor had the highest distant metastatic rate?

A

MM - 30%

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26
Q

Sarowitz BN, Davis GJ, Kim S.
Outcome and prognostic factors following curative‐intent surgery for oral tumours in dogs: 234 cases (2004 to 2014. Journal of Small Animal Practice. 2017;58(3):146-153.

What was the overall rate of clean margins with 2 cm surgical planning?

A

85%

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27
Q

Coyle VJ, Rassnick KM, Borst LB, et al.

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007. Veterinary and Comparative Oncology. 2015;13(2):89-97.

What was the overall metastatic rate?

A

58%

28
Q

Coyle VJ, Rassnick KM, Borst LB, et al.

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007. Veterinary and Comparative Oncology. 2015;13(2):89-97.

What was the MST?

What did most dogs die from?

A

525 days

90% died due to metastases

29
Q

Coyle VJ, Rassnick KM, Borst LB, et al.

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007. Veterinary and Comparative Oncology. 2015;13(2):89-97.

In the multivariate analysis what factors had prognostic significance?

A

no chemo 2.8x hazard of death over getting chemo

histologic grade II or III had a 2.8 hazard of death over dogs that had grade I

30
Q

Coyle VJ, Rassnick KM, Borst LB, et al.

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007. Veterinary and Comparative Oncology. 2015;13(2):89-97.

what was the median metastasis free interval (MFI)?

A

627 days

31
Q

Coyle VJ, Rassnick KM, Borst LB, et al.

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007. Veterinary and Comparative Oncology. 2015;13(2):89-97.

In the univariate analysis what additional factor was prognostic for shorter met free interval and survival?

A

Mitotic index >40

32
Q

Gardner H, Fidel J, Haldorson G, Dernell W, Wheeler B.

Canine oral fibrosarcomas: a retrospective analysis of 65 cases (1998–2010. Veterinary and Comparative Oncology. 2015;13(1):40-47.

Which treatment/combo had the greatest effect on MST and PFI?

What were they for all others?

A

Surgery + radiation

PFI 301 days

MST 505 days

All others

PFI 138 days

MST 220 days

33
Q

Gardner H, Fidel J, Haldorson G, Dernell W, Wheeler B.

Canine oral fibrosarcomas: a retrospective analysis of 65 cases (1998–2010. Veterinary and Comparative Oncology. 2015;13(1):40-47.

Which prognostic factors were identified that had an effect on PFI?

A

tumor location

radiation protocol

34
Q

Gardner H, Fidel J, Haldorson G, Dernell W, Wheeler B.

Canine oral fibrosarcomas: a retrospective analysis of 65 cases (1998–2010. Veterinary and Comparative Oncology. 2015;13(1):40-47.

Which factors were identified that had a significant effect on survival?

A

location, tumor size/stage, type of surgery, margins, and grade

35
Q

Frazier SA, Johns SM, Ortega J, et al.

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*. Veterinary and Comparative Oncology. 2012;10(1):33-43.

In this study, what were the MST and PFI?

A

MST 743 days

PFI >653 days

36
Q

Frazier SA, Johns SM, Ortega J, et al.

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*. Veterinary and Comparative Oncology. 2012;10(1):33-43.

in this study what was the effect of radiation therapy?

A

No significant difference

37
Q

Frazier SA, Johns SM, Ortega J, et al.

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*. Veterinary and Comparative Oncology. 2012;10(1):33-43.

What proportion of dogs developed local recurrence? what proportion developed metastases?

A

24% and 24%

38
Q

Frazier SA, Johns SM, Ortega J, et al.

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*. Veterinary and Comparative Oncology. 2012;10(1):33-43.

what breed was overrepresented, and what was found in these dogs?

A

golden retriever.

Shorter PFI, 514 days versus not reached for non goldens

39
Q

Frazier SA, Johns SM, Ortega J, et al.

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*. Veterinary and Comparative Oncology. 2012;10(1):33-43.

What factor affected local recurrence?

what was the PFI?

A

having a dirty margin

316 versus not reached.

40
Q

Riggs J, Adams VJ, Hermer JV, Dobson JM, Murphy S, Ladlow JF.
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. Journal of the American Veterinary Medical Association. 2018;253(1):73-83.

What was the overall MST, MST for SCC and MST for FSA?

A

overall 2049 days

MST not reached for SCC

557 days for FSA

41
Q

Riggs J, Adams VJ, Hermer JV, Dobson JM, Murphy S, Ladlow JF.
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. Journal of the American Veterinary Medical Association. 2018;253(1):73-83.

Did RT improve survival in SCC with dirty margins?

A

Yes - MST 2051 d for dirty margins with radiation

MST 181 days for dirty margins without radiation

42
Q

Riggs J, Adams VJ, Hermer JV, Dobson JM, Murphy S, Ladlow JF.
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. Journal of the American Veterinary Medical Association. 2018;253(1):73-83.

Did RT have a benefit in dogs with FSA who had dirty margins?

A

NO - MST 299 with radiation, MST 694 without radiation

43
Q

Riggs J, Adams VJ, Hermer JV, Dobson JM, Murphy S, Ladlow JF.
Outcomes following surgical excision or surgical excision combined with adjunctive, hypofractionated radiotherapy in dogs with oral squamous cell carcinoma or fibrosarcoma. Journal of the American Veterinary Medical Association. 2018;253(1):73-83.

In the multivariate analysis, what remained as significant for SCC and FSA?

A

SCC - nothing

FSA - caudal location bad and females seem to have higher risk (first time this has been reported)

44
Q

Soltero-Rivera MM, Krick EL, Reiter AM, Brown DC, Lewis JR.

Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005–2011). Journal of Feline Medicine and Surgery. 2014;16(2):164-169.

What was the proportion of cats had LN metastases?

A

31%

45
Q

Soltero-Rivera MM, Krick EL, Reiter AM, Brown DC, Lewis JR.

Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005–2011). Journal of Feline Medicine and Surgery. 2014;16(2):164-169.

What proportion of cats had thoracic metastases?

A

10%

46
Q

Soltero-Rivera MM, Krick EL, Reiter AM, Brown DC, Lewis JR.

Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005–2011). Journal of Feline Medicine and Surgery. 2014;16(2):164-169.

How did metastases at diagnosis affect survival time?

A

no significant difference

47
Q

Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A.

Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of veterinary internal medicine. 2011;25(3):504.

What was the MST in this study?

A

overall 163 days

48
Q

Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A.

Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of veterinary internal medicine. 2011;25(3):504.

what factors were predictive for longer survival?

A

Site was predictive for survival, as was complete response at 30 days

49
Q

Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A.

Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of veterinary internal medicine. 2011;25(3):504.

which sites had more favourable survival?

A

Tonsil and buccal mucosa - only 5 cats in this group

MST not reached, average 724 days

50
Q

Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A.

Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of veterinary internal medicine. 2011;25(3):504.

What was the MST for for cats with complete response at 30 days versus incomplete response.

A

complete remission at 30 days - 379 days

incomplete remission - 115 days

51
Q

Fidel J, Lyons J, Tripp C, Houston R, Wheeler B, Ruiz A.

Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of veterinary internal medicine. 2011;25(3):504.

Which factors were not associated with prognosis?

A

tumor stage and tumor size

52
Q

Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs

Ana Rejec, DVM, PhD; Jerome Benoit DVM, MRCVS; Cedric Tutt, BVSc, MRCVS; DavidCrossley, BVetMed, PhD, MRCVS; Janos Butinar, DVM, PhD; NatasaIhanHren, DM, PhD

what were the outcomes in cats?

A
  • 4/5 cats had a complete response, 1/5 had a partial response
  • Cat 1 E/D due to mammary carcinoma 89d after rad.
  • Cat 2 E/D due to renal failure 65 d after rad
  • Cat 3 E/D after 201d due to tumor progression (partial response)
  • Cat 4 E/D after 348d due to pulmonary mets, tx’dwith carboplatin
  • Cat 5 Alive at data analysis 335d
53
Q

Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs

Ana Rejec, DVM, PhD; Jerome Benoit DVM, MRCVS; Cedric Tutt, BVSc, MRCVS; DavidCrossley, BVetMed, PhD, MRCVS; Janos Butinar, DVM, PhD; NatasaIhanHren, DM, PhD

What were the outcomes in dogs?

A
  • Dogs all completed treatment
  • Dog 1 –Alive at 1025 days
  • Dog 2 –E/D due to cardiac failure at 919 d
  • Dog 3 –local recurrence in tonsil at 752d, E/D at 844d
54
Q

Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs

Ana Rejec, DVM, PhD; Jerome Benoit DVM, MRCVS; Cedric Tutt, BVSc, MRCVS; DavidCrossley, BVetMed, PhD, MRCVS; Janos Butinar, DVM, PhD; NatasaIhanHren, DM, PhD

What early and late effects of radiation were seen in cats?

A
  • All cats experienced early side effects (mucositis) and all had e-tube placed
  • Late side effects such as fibrosis, bone necrosis, or nervous tissue damage were not observed in 4/5 cats. The cat with laryngeal SCC that lived > 1-year developed some changes in vocalization 7-months after radiotherapy.
  • No other serious late side effects were observed
55
Q

Evaluation of an Accelerated Chemoradiotherapy Protocol for Oropharyngeal Squamous Cell Carcinoma in 5 Cats and 3 Dogs

Ana Rejec, DVM, PhD; Jerome Benoit DVM, MRCVS; Cedric Tutt, BVSc, MRCVS; DavidCrossley, BVetMed, PhD, MRCVS; Janos Butinar, DVM, PhD; NatasaIhanHren, DM, PhD

What early and late effects of radiation were seen in dogs?

A

although all dogs experienced grade 2-3 mucosal toxicity, esophagostomy tube placement was not required.

Surprisingly, no late radiation side effects were observed in the 3 dogs of this study 2-years after chemoradiotherapy

56
Q

Randall EK, Kraft SL, Yoshikawa H, Larue SM.
Evaluation of 18F‐FDG PET/CT as a diagnostic imaging and staging tool for feline oral squamous cell carcinoma. Veterinary and Comparative Oncology. 2016;14(1):28-38.

What was PET CT particularly good at?

A
  • Soft tissue infiltrative tumors that were subtle and ill defined on CT were highly visible and more extensive on FDG-PET/CT.
  • Three cytologically confirmed metastases were hypermetabolic on PET, while two of those metastases were equivocal on CT.
57
Q

Randall EK, Kraft SL, Yoshikawa H, Larue SM.
Evaluation of 18F‐FDG PET/CT as a diagnostic imaging and staging tool for feline oral squamous cell carcinoma. Veterinary and Comparative Oncology. 2016;14(1):28-38.

Where did PET CT perform similarly to standard CT images?

A

•Tumors invading the osseous structures were more similar in extent on 18FDG-PET/CT and CT although they were more conspicuous on PET images.

58
Q

Which types of canine papilloma virus causes oral lesions?

A

1, 13, 17, 19

papilloma 1 is in adriana case report from JVD

other case report is linked to type 17

59
Q

Boston SE, Lu X, Culp WTN, et al.
Efficacy of systemic adjuvant therapies administered to dogs after excision of oral malignant melanomas: 151 cases (2001 2012 ). Journal of the American Veterinary Medical Association. 2014;245(4):401.

What was the MST in this study?

A

346 days

60
Q

Boston SE, Lu X, Culp WTN, et al.
Efficacy of systemic adjuvant therapies administered to dogs after excision of oral malignant melanomas: 151 cases (2001-2012). Journal of the American Veterinary Medical Association. 2014;245(4):401.

What were negative prognostic indicators in this study?

A

Patient age

Tumor Size

Type of excision

61
Q

Boston SE, Lu X, Culp WTN, et al.
Efficacy of systemic adjuvant therapies administered to dogs after excision of oral malignant melanomas: 151 cases (2001-2012). Journal of the American Veterinary Medical Association. 2014;245(4):401.

Which adjunctive treatments showed a survival benefit in multivariate analysis?

A

None! Chemo, radiation and melanoma vaccine examined

62
Q

Grosenbaugh DA, Leard AT, Bergman PJ, et al.
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. American journal of veterinary research. 2011;72(12):1631.

What product was being studied?

A

Oncept - merial

63
Q

Grosenbaugh DA, Leard AT, Bergman PJ, et al.
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. American journal of veterinary research. 2011;72(12):1631.

What was the MST of dogs in the study, what was MST of the controls?

A

324 days for controls

not reached for study dogs.

64
Q

Grosenbaugh DA, Leard AT, Bergman PJ, et al.
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. American journal of veterinary research. 2011;72(12):1631.

What was the 25th percentile survival of dogs in the study, what was it for the controls?

A

vaccinates - 464 days

controls - 156 days

65
Q
A