Jacewicz - Speech and Language Flashcards

1
Q

What is speech?

A
  • Communication via vocalized sounds (phonation) that form spoken words and sentences
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2
Q

What is phonation?

A

Distinct sounds produced by larynx

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3
Q

What is a phoneme?

A
  • A distinct sound that contrasts with others (American English has 25 consonant and 17 vowel phonemes)
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4
Q

What is dysphonia?

A
  • Disturbance of phonation causing alteration of volume (hyper- and hypophonia)
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5
Q

What is dysarthria?

A
  • Disturbance of articulation caused by impaired motor control, resulting in slurring of speech
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6
Q

What is mutism?

A

Absence of phonation

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7
Q

What is the anatomic substrate for speech?

A
  • Neocortex w/sensory (blue) and motor (maroon) strips and overlying homunculi
  • Sagittal section through lower face and neck to emphasize mm used in normal phonation
    1. These mm incl the tongue, and mm controlling the lips, pharynx, vocal cords, etc
  • Any disruption to these motor pathways or the mm themselves can cause slurring of words denoted as dysarthria
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8
Q

How can you examine a pt’s speech?

A
  • Assess spontaneous speech, have subject read, and repeat selected phrases, e.g., “round the rugged rock the ragged rascal ran”
  • Listen for:
    1. Speech volume: INC in hearing deficits, DEC in vocal cord and extrapyramidal disorders, e.g., PD
    2. Rate of speech: INC in fluent aphasia, DEC in non-fluent aphasia
    3. Articulation: abnormal in many CNS and PNS disorders, and in end-organ lesions
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9
Q

What is language?

A
  • System of arbitrary symbols (sounds, written symbols, gestures) that permit communication of thoughts, ideas, emotions, etc.
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10
Q

What is aphasia?

A

Loss of ability for spoken and written language

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11
Q

What is alexia?

A

Loss of ability to read when no visual impairment exists

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12
Q

What is agraphia?

A

Loss of ability to write when no motor impairment exists

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13
Q

What is paraphasia? 2 types?

A
  • Language errors due to word or sound substitution
    1. Semantic paraphasia: substitution of one word for another, e.g., fork for spoon
    2. Phonemic paraphasia: substitution of one sound for another, e.g., moon for spooon
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14
Q

What is neologism?

A

Creation of meaningless words, e.g., woon for spoon

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15
Q

What is semantics?

A
  • Meaning or interpretation of a word, sentence, or other language form, i.e., language lexicon
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16
Q

What is syntax?

A
  • System of rules (grammar) implicit in a language, viewed as a mechanism for generating all sentences possible in that language
17
Q

What is prosody?

A
  • Tone, inflection, volume of words and sentences that add meaning to language
18
Q

What is the anatomic substrate for language?

A
  • Arcuate fasciculus and other peri-Sylvian fibers connecting Wernicke’s (BA #22) and Broca’s (BA #44-45) areas
  • Not shown in this image are the connections bt the main language areas (W and B) and the o/association areas of the frontal, temporal, and parietal lobes
  • It also does not demonstrate connections to the non- dominant hemisphere that provide emotional color to language
  • Lesions of these connecting fibers will cause aphasia with unique characteristics
19
Q

What are the 3 main language disorders and their characteristics (image)?

A
20
Q

How does the lateralization of language work?

A
  • >95% of R-handed ppl are left-hemisphere dominant
  • About 65% of L-handed ppl are L-hemisphere dominant, 15-20% are R-hemisphere dominant, and the rest have mixed dominance
21
Q

Imagine this is a R-handed split-brain subject. How will his responses vary based on the hand he uses to examine the objects blocked from his vision?

A
  • When this R-handed split brain subject is asked to name small geometric objects w/o seeing them, he provides the correct answer when he handles the object w/his right hand -> sensory info registers in left hemisphere, which then connects w/language area
  • However, when he handles the objects with his left hand (sensory info to the right hemisphere, which is disconnected from the language areas in the left hemisphere), he is unable to name the objects
  • NOTE: split brain due to sectioning of the corpus callossum
22
Q

What does this image illustrate?

A
  • Another method for testing split brain subjects: visual input restricted to either left or right calcarine (visual) cortex
  • Same results are obtained as described in the tactile test, i.e. info transmitted to R visual cortex (seen with L eye) cannot reach language areas in L hemisphere -> although subject can see the objects he cannot name them
23
Q

What does this image illustrate?

A
  • When subject is instructed to passively view a word, calcarine cortex lights up indicating INC metabolic activity and thus neuronal activation
  • When subject listens to the word with no visual input, Hershel’s gyrus and Wernicke’s area light up
  • NOTE: SPECT scans register changes in regional cerebral metabolism, measured with positron emitting isotopes, in this case radioactive deoxyglucose
24
Q

What does this image illustrate?

A
  • When subject speaks the word, the facial area of the motor strip and Broca’s area light up
  • When subject is asked for more complex language-related task, e.g., to generate word associations, the language association areas light up
  • NOTE: SPECT scans register changes in regional cerebral metabolism, measured with positron emitting isotopes, in this case radioactive deoxyglucose
25
Q

Describe the left/right hemisphere language functions in a left hemisphere dominant individual (table).

A
  • Orange boxes around specific lang funcs of the 2 hemispheres
  • L HEMI: lexical and syntactic language, writing, and spoken word abilities
  • R HEMI: some rudimentary spoken language and the emotional coloring of language (prosody)
  • NOTE: stereognosis = mental perception of depth or 3-dimensionality by the senses, usually in reference to the ability to perceive form of solid objects by touch
26
Q

What are the 6 components of language testing?

A
  • Expression: normal verbal output 100-150 words/min; assess through spontaneous convo
  • Comprehension of spoken language: test ability to follow simple and complex spoken commands
  • Repetition: ask subject to repeat single words and phrases
  • Reading: ask subject to read aloud and follow a written command
  • Writing: ask subject to write a sample sentence
  • Naming: ask subject to identify common objects
27
Q

What is Broca’s aphasia?

A
  • Perisylvian syndrome: non-fluent, expressive aphasia
  • Reduced verbal output, <50 words/min; single word or short phrase (<5 words)
  • Word use restricted to nouns, verbs, adjectives, with limited use of syntactical words, e.g., adverbs, articles, prepositions
  • Comprehension relatively spared, but some trouble w/understanding complex syntactical language
  • Repetition poor, agrammatic; paraphasias common
  • Lesion to BA #44-45
  • Causes multiple; MCC is a stroke
28
Q

What is Wernicke’s aphasia?

A
  • Perisylvian syndrome: fluent, receptive aphasia
  • Verbal output normal or INC; about 200 words/min
  • Sentences devoid of meaningful lang, most noticeable is absence of nouns, replaced by pronouns and prepositions
  • Comprehension seriously impaired, repetition poor, and paraphasic errors and neologism common
  • Lesion at BA #22; causes multiple, but MCC stroke
29
Q

What is global aphasia?

A
  • Perisylvian syndrome
  • Both expressive AND receptive language function seriously impaired
  • Nonfluent, common paraphasic errors
  • Lesion involves large area of L hemisphere
  • Causes similar to Broca’s/Wernicke’s aphasia (e.g., stroke)
30
Q

What is conduction aphasia?

A
  • Perisylvian syndrome
  • Comprehension and fluency relatively good
  • Repetition poor and paraphasic errors common
  • Lesion location in supramarginal gyrus and arcuate fasciculus
  • MCC occlusion of angular branch of left middle cerebral artery
31
Q

What is transcortical motor aphasia?

A
  • Extra-sylvian syndrome
  • Uncommon aphasia similar to Broca’s, except subjects able to repeat
  • Lesion in left anterior frontal lobe, superior or inferior to Broca’s area; lesions of left basal ganglia may be a rare lesion site
  • Causes similar to Broca’s (e.g., stroke)
32
Q

What is transcortical sensory aphasia?

A
  • Extra-sylvian syndrome
  • Uncommon aphasia similar to Wernicke’s, except subjects able to repeat
  • Lesion in border zone bt left middle cerebral and posterior cerebral aa
  • Causes similar to Wernicke’s, but also severe hypotension
33
Q

What is mixed transcortical aphasia?

A
  • Extra-sylvian aphasia
  • Uncommon aphasia similar to global aphasia, except subjects are able to repeat
  • Lesion in border zone bt left middle cerebral and ant cerebral aa
  • Causes are stroke and severe hypotension
34
Q

What is anomic aphasia?

A
  • Extra-sylvian syndrome
  • Poorly defined since all aphasias have naming difficulty
  • Lesion location can be anywhere in language area
  • Gerstmann syndrome: anomia, alexia, agraphia, right-left disorientation, acalculia, finger agnosia, lesion localized to left angular gyrus (BA #39)
35
Q

What is sub-cortical aphasia?

A
  • Extra-sylvian aphasia
  • Subjects with lesions of left basal ganglia or left thalamus
  • May be associated with variable forms of aphasia
36
Q

What is alexia without agraphia?

A
  • Extra-sylvian syndrome
  • Inability to read with preserved ability to write
  • Lesion in left medial occipital and medial temporal lobe, involving splenium of corpus callossum
  • Cause is branch occlusion of left posterior cerebral artery
37
Q

What will this lesion cause?

A
  • Alexia without agraphia: unusual bc reading and writing typically are linked language functions
  • Lesion that produces this syndrome shown in purple, and involved the left visual cortex and splenium of the corpus callosum
  • Language areas of L hemisphere are intact, so pt able to speak normally and write normally, but they cannot read
  • Pt has a R visual field deficit (R homonymous hemianopsia) -> they have no registration of R visual field and left visual field info (which registers normally in R visual cortex) cannot reach language areas bc of splenium lesion, so the pt is unable to read
38
Q

What is the language syndrome algorithm?

A
  • Testing the patient for fluency, comprehension, and the ability to repeat simple phrases permits the categorization of all aphasic syndromes
  • Color-coded circle under each type of aphasia helps to identify the anatomical lesion responsible for that aphasia
39
Q

What are the 9 language aphasias, and their differentiating features (table)?

A
  • NOTE: only the first 4 columns are useful in separating one aphasic syndrome from all the others