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Microbiology Flashcards > IX - Virology > Flashcards

IX - Virology Flashcards

1
Q

All enveloped viruses acquire envelope from plasma membrane except -

A

Herpesvirus (nuclear membrane)

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2
Q

All viruses are haploid except

A

Retrovirus

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3
Q

Negative-polarity RNA must be converted to positive-polarity RNA for transcription by this enzyme

A

RNA-dependent RNA polymerase

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4
Q

Segmented genone virus

A

BOAR - Bunya, Orthomyxo, Arena, Reo

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5
Q

Negative-polarity RNA (require polymerase)

A

Arena, Bunya, Paramyxo, Orhtomyxo, Filo, Rhabdo

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6
Q

Viral phase, single virus enters cell

A

Phase 0 - Entry

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7
Q

Viral phase, decrease in number of virus

A

Phase 1 - Decline

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8
Q

Viral phase, no virus detectable

A

Phase 2 - Eclipse

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9
Q

Viral phase, increase in virus

A

Phase 3 - Rise

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10
Q

Viral phase, steady number of virus, plateau

A

Phase 4 - Latent

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11
Q

Viral phase, cytopathic effects, cell death

A

Phase 5 - Cytopathic effect

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12
Q

Visual or functional effect of virus in cell

A

Cytopathic effect

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13
Q

Oncogenic effect of virus in cell

A

Malignant transformation

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14
Q

Cells are infected but appear normal, producing large numbers of virus

A

Commensal symbiosis

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15
Q

Bind to cytokine, virulence factor

A

Cytokine decoy

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16
Q

Reduce expression of APCs, virulence factor

A

Virokines

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17
Q

Gold standard in viral diagnosis

A

Replication of DNA or RNA thru DNA probe or PCR

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18
Q

Live-attenuated vaccines

A

MMR, Sabin’s polio, varicella, yellow fever, small pox

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19
Q

Killed vaccines

A

Rabies, Influenza, Salk Polio, Hep A

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20
Q

All DNA viruses are double stranded except

A

Parvovirus

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21
Q

All DNA viruses are icosahedral except

A

Pox virus

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22
Q

All DNA viruses replicate in the nucleus except

A

Pox virus

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23
Q

All DNA viruses have linear DNA except

A

Papilloma, Polyoma, Hepdna

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24
Q

Presents with slapped-cheek apperacne, fever, coryza

A

Erythema infectosum / Fifth Disease (Parvo B19)

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25
Transmission of ParvoB19
Transplacental (fetal hydrops/death), Respiratory
26
Causes aplastic crisis in pts with sickle cell anemia, thalasemia, spherocytosis
Parvovirus
27
Only virus with a fiber (penton)
Adenovirus
28
Spectrum of diease may be conjunctivitis, pharyngitis, atypical pneumonia, hemorrhagic cystitis
Adenovirus
29
Cowdry B bodies
Adenovirus, Poliovirus
30
Koilocytes / cytoplasmic inclusion, fried egg apperance in
HPV
31
Etiology of veruca vulgaris
HPV 1-4
32
Etiology of condyloma acuminata (anogenital warts)
HPV 6, 11
33
Most common viral STD
HPV 6, 11
34
Carcinogenic HPV strains
HPV 16, 18, 31, 33 courtesy of gene E6, E7
35
Vaccine, HPV 6, 11, 16, 18
Gardacil (Quadrivalent)
36
Vaccine, HPV 16, 18
Cervarix (Bivalent)
37
Etiology, Progressive Multifocal Leukoencephalopathy
JC Polyoma
38
Etiology, hemorrhagic cystitis, nephropathy in immunocompromised
BK Polyoma
39
Stomatitis, herpes labialis, karatoconjunctivitis
HSV-1
40
Genital herpes, aseptic meningitis, neonatal herpes
HSV-2
41
Latency site in HSV-1
Trigeminal ganglia
42
Latency site in HSV-2
Lumbosacral ganglia
43
DOC in HSV
Acyclovir
44
Cowdry A bodies on Tzanck smear
HSV (intranuclear)
45
Mulinucleated giant cells, intranuclear
VZV
46
Centrifugal rash at different stages, dewdrop on a rose petal
Varicella
47
VZV reactivation, postherpetic neuralgia
Herpes zoster
48
VZV involving geniculate ganglion
Ramsay Hunt Syndrome
49
DOC in VZV
Acyclovir, when severe
50
Giant cells with owl's eye intranuclear inclusions
CMV
51
Most common cause of congenital abnormalities
CMV
52
Heterophil-negative mononucleosis
CMV
53
MCC of blindness in HIV pts
CMV (systemic mononucleosis)
54
DOC in CMV
Gancyclovir (Forscarnet for CMV retinitis)
55
Kissing disease, heterophil-positive mononucleosis, Downy cells, splenomegaly
EBV
56
Malignant transormation in EBV
Nasopharyngeal CA, Burkitt lymphoma, Non-Hodgkin lymphomas
57
Malignancy of vascular endothelium, AIDS-defining illness
Kaposi Sarcoma (HHV-8)
58
Largest virus, Guarnieri bodies, intracytoplasmic
Variola
59
Henderson-Peterson bodies
Molluscum contagiosum
60
DOC for molluscum contagiosum
Cifodovir
61
First vaccine to prevent human cancer was for which virus
Hepa B
62
DOC for Hep B
Interferon A, Lamivudine
63
Autoimmune vasculitides in Hepa B
Polyarteritis nodosa
64
All RNA are single stranded except
Reo, Rota
65
All RNAs replicate in cytoplasm except
Retrovirus and Influenza
66
Most common clinical form of polio
Abortive poliomyelitis
67
Polio vaccine, prevents GI replication, transmission
Sabin (Live)
68
Vesicular sorethorat/herpangina
Coxsackie
69
Hand-foot-and-mouth disease, vesicles on hands and feet
Coxsackie
70
MCC of viral myocarditis
Coxsackie
71
MCC of aseptic meningitis
Coxsackie
72
Enteric cytopathic human orphan
Echovirus
73
Common cold, acid-labile, does not cause enteritis
Rhinovirus
74
Self-limited hepatitis
Hepa A aka Enterovirus 72
75
MCC of nonbacterial diarrhea in adults
Norwalk/Norovirus
76
MCC of childhood diarrhea
Rotavirus
77
Influenza that causes pandemics
Influenza A via shifts
78
Influenza that causes epidemics
Influenza B via drifts
79
Influenza spike that binds to receptor
Hemagglutinin
80
Influenza spike that cleaves nuraminic acid
Neuraminidase
81
Influenza spikes present in humans
H 1,2,3 N 1,2
82
DOC in influenza
Oseltamivir
83
Warthin-Finkeldy bodies (multinucleated giant cells)
Measles
84
Koplik spots
Measles
85
Subacute sclerosing panencephalitis / Damson disease
Measles
86
Parotitis, orchitis, meningitis
Mumps
87
Surface spikes are fusion proteins only
RSV
88
Most IMPORTANT cause of pneumonia and bronchiolitis in infants
RSV
89
DOC for RSV
Ribavirin
90
Laryngotracheobroncitis (Croup)
Parainfulenza 1,2
91
Steeple sign
Parainfulenza 1,2
92
Animal bite, axonal CNS transport, hypersalivation, laryngospasm, hydrophobia, encephalitis
Rabies
93
Negri bodies, bullet-shaped
Rabies
94
Only vaccine routinely used post-exposure is for
Rabies
95
SARS, non-cavitary ground glass infiltrates
Corona
96
Influenza-like, breakbone fever, maculopapular rash
Dengue
97
Most prevalent blood-borne pathogen
Hep C
98
Chronic hepatitis, cirrhosis, CA
Hep C
99
Main cause of essential mixed cryoglobulinemia
Hep C
100
MC indcation for liver transplant
Hep C
101
German measles, postauricular LAD, polyarthritis
Rubella
102
Sensorineural deafness, congenital ataracts, PDA, mental retardation, blueberry baby
Rubella
103
Diploid virus
HIV
104
HIV, transmembrane protein
p41
105
HIV, surface protein
p120
106
HIV, nucleoprotein
p7
107
HIV, major capsid protein
p24
108
HIV, outer matrix protein
p17
109
HIV, p24, p7, p17 gene
gag
110
HIV, p41, p120 gene
env
111
HIV, reverse transciptase, protease, integrase gene
pol
112
HIV protein, rapidly changing antigenic variants
p120
113
Most common complication of HIV
AIDS (CD4 <200)
114
Most common AIDS-defining disease
PCP
115
#1 killer in AIDS
pTB
116
#1 cause of blindness in AIDS
CMV
117
#1 cause of meningitis in HIV
Cryptococcus neoformans
118
#1 cause of chronic diarrhea in AIDS
C. parvum
119
Definitive diagnosis of AIDS
Western blot
120
HIV prognostication
HIV RNA
121
Retrovirus causing adult T-cell leukemia
HTLV
122
MCC of epidemic encephalitis, thalamic infarcts
Japanese B virus

Microbiology Flashcards (11 decks)

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