II - Infection Biology

Question 1

Pathogens that cause disease in immunocompromised

Answer 1

Opportunistic Pathogens

Question 2

Measure of a microbe’s ability to cause disease

Answer 2

Virulence

Question 3

Number of organisms required to cause disease in 50% of pop’n

Answer 3

ID50

Question 4

Modes of bacterial adherence

Answer 4

Pili, glycocalyx

Question 5

Adherence protein of Salmonella and E.coli

Answer 5

Curli

Question 6

Enzymes that degrade subcutaneous tissue

Answer 6

Collagenase, hyaluronidase (spreading factor)

Question 7

Enzyme that accelerates fibrin clot formation

Answer 7

Coagulase

Question 8

Protein for adherence to mucosal membranes

Answer 8

IgA protease

Question 9

Enzyme, destroys neutrophils and macrophages

Answer 9

Leukocidin (Panton Valentine Lekocidin in Staph. Aureus)

Question 10

Bacteria with IgA protease

Answer 10

Strep. Pneumoniae, Haemophilus influenzae, Neisseria gonorrhea, Neisseria meningitidis

Question 11

Vaccine for exotoxins

Answer 11

Toxoids, none for endotoxins

Question 12

MOA of diphtheria toxin, cholera toxin, pertussis toxin

Answer 12

ADP ribosylation

Question 13

MOA of TSS toxin, staph enterotoxin, erythrogenic toxin

Answer 13

Superantigen

Question 14

MOA of tetanus toxin, botulinum toxin, scalded skin toxin

Answer 14

Protease

Question 15

MOA of Clostridium perfringens alpha toxin

Answer 15

Lecithinase

Question 16

Toxic component of lipopolysaccharide (endotoxin)

Answer 16

Lipid A

Question 17

All bacteria have peptidogylcan cell walls except

Answer 17

Mycoplasma pneumoniae (none)

Question 18

All G(+) have no endotoxin except

Answer 18

Listeria monocytogenes

Question 19

All bacterial capsules are composed of polysaccharide except

Answer 19

Bacillus anthracis

Question 20

All exotoxins are heat-labile except

Answer 20

Staphylococcal enterotoxin

Question 21

Clostridium perfringerns agar

Answer 21

Egg yolk

Question 22

Corynebacterium diphtheriae agar

Answer 22

Tellurite

Question 23

group D streptococci

Answer 23

Bile Esculin Agar

Question 24

Staphylococci agar

Answer 24

Mannitol salts

Question 25

N. meningitidis, N. gonorrhea (sterile)

Answer 25

Chocolate agar

Question 26

N. gonorrhea (from nonterile sites) agar

Answer 26

Thayer-Martin

Question 27

Haemophilus inluenzae agar

Answer 27

Chocolate + Factors X, V

Question 28

Antibiotics in Thayer-Martin agar

Answer 28

Vancomycin, Cholestin, Nystatin

Question 29

Mycobacterium tuberculosis agar

Answer 29

Lowenstein-Jensen agar

Question 30

Vibrio cholerae agar

Answer 30

Thiocyanate Citrate Bile Salts/Sucrose Agar

Question 31

Bordetella pertussis agar

Answer 31

Bordet-Gengou agar

Question 32

Legionella pneumophilla agar

Answer 32

Charchoal yeat agar

Question 33

Campylobacter, Helicobacter agar

Answer 33

Skirrow’s/Campi agar

Question 34

Borrelia burgdorferi agar

Answer 34

Barbour-Stoenner-Kelly (BSK)

Question 35

Mycoplasma pneumonia agar

Answer 35

Eaton

Question 36

Pseudomonas aeuroginosa agar

Answer 36

Cetrimide

Question 37

Salmonella, shigella agar

Answer 37

Xylose-lysine-deoxycholate

Question 38

Leptospira interrogans

Answer 38

Ellinghausen-McCullough-Johnson-Harris/Fletcher’s

Question 39

Excellent BBB penetration with or without inflammation

Answer 39

(FIRST Cranial Med in Flame) Fluconazole, Isoniazid, Rifampicin, Sulfonamides, Trimethoprim, Chloramphenicol, Metronidazole, Flucytosine

Question 40

No BBB passage even with inflammation

Answer 40

(P12CA)Polymixins, 1/2 Cephalosporins (except Cefuroxime), Amphotericin B

Question 41

Good BBB penetrance only with inflammation

Answer 41

(Im Vying MAC PC)Imipenem+Cilastatin, Vancomycin, Meropenem, Aztreonam, Ciprofloxacin, Penicillins, Cephalosporins (Cefuroxime, all 3 except cefoperazone, cefipime)

Question 42

Minimal BBB passage even with inflammation

Answer 42

(MALT) Macrolides, Aminoglycosides, Lincosamides, Tetracyclines