Isoproterenol (Isuprel)

Question 1

Isoproterenol class

Answer 1

Sympathomimetic

Question 2

Isoproterenol MOA

Answer 2

Beta- adrenergic receptor stimulator, increases chronotope, inotrope, dromotrope, and myocardial O2 consumption. Bronchodilator. Decreases PVR, causes venous pooling.

Question 3

Isoproterenol indications

Answer 3

Hemodynamically significant bradycardia refractory to atropine and transcutaneous pacing.

Question 4

Isoproterenol contraindications

Answer 4

Hypersensitivity, AMI

Question 5

Isoproterenol Adverse reactions

Answer 5

Palpitations, tachycardia angina, hypotension, headache, nervousness, tremors, may cause MI in elderly.

Question 6

Isoproterenol dosage

Answer 6

Adult: 2-10 mcg/min IV/IO titrated to systolic blood pressure of 90 mm Hg or heart rate > 60 bpm (make by mixing 2 mg in 500 mL)

Pediatric: 0.1-1 mcg/min IV/IO (make by mixing 0.5 mg in 250 mL)

Question 7

Isoproterenol Duration

Answer 7

Onset: 60-90 secs
Peak: 5 minutes
Duration: 1-2 hours

Question 8

Isoproterenol special considerations

Answer 8

Should be nebulized for bronchodilation

Question 9

Isoproterenol pregnancy category

Answer 9

C

Question 10

Isoproterenol How supplied

Answer 10

2mg in 10 mL ampules