Adenosine Flashcards
Adenosine class
Antiarrhythmic
Adenosine MOA
Endogenous nucleotide that slows conduction time through the SA AND AV node; can interrupt re-entrant pathways; slows heart rate; acts directly on sinus pacemaker cells.
Adenosine indications
SVT and Paroxysmal Supraventricular Tachycardia (PSVT). May be used as a diagnostic tool for regular monomorphic wide complex tachycardia.
Adenosine contraindications
Torsades de Pointes, second- or third- degree heart block or sick sinus syndrome, atrial fibrillation/flutter, ventricular tachycardia, hypersensitivity, poison induced tachycardia.
Adenosine Adverse reactions
Facial flushing, SOB, chest pain, headache, paresthesia, diaphoresis, palpitations, hypotension, nausea, short lasting blocks or asystole or bradycardias at the time of conversion.
Adenosine drug interactions
Methylxanthines antagonize the effects of adenosine. Dipyridamole potentiates the effects of adenosine. Carbamazepine may potentiate the AV node, blocking the effects of adenosine. May cause bronchoconstriction in asthmatic patients.
Adenosine dosage
Adult: 6 mg rapid IV bolus, followed by a 10 mL saline flush. If no
response after 1 – 2 minutes, repeat with 12 mg IV bolus with 10mL saline
flush.
Pediatric: 0.1 – 0.2 mg/kg rapid IV; maximum single first dose of 6 mg
and second dose of 12 mg
Adenosine duration
Onset: seconds
Duration: 12 seconds
Adenosine special considerations
Short half-life limits side effects in most patients, but arrhythmias including blocks are common at the time of conversion. Should be administered directly into a large bore medication port closest to the patient and followed by a flush.
Adenosine pregnancy category
C
Adenosine how supplied
6mg in 2mL vial or preloaded syringe, 12 mg in 4mL vial or preloaded syringe
