ISBB Flashcards

1
Q

Phenotype of D negative

a. (+/+)
b. (-)
c. (+)
d. (-/-)

A

b

Genotype: (-/-)

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2
Q

Anti-Sda can be neutralized by:

a. Hydatic Cyst Fluid
b. Plasma
c. Urine
d. Human Breast Milk

A

C

Anti-sda - isda = panghe

  • mostly IgM
  • Reactivity: small, refractile (shiny) agglutinates
  • Enhanced by enzyme
  • Generally clinically insignificant antibody
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3
Q

The ability of a single cytokine to alter the expression of several genes is called:

a. Endocrine
b. Autocrine
c. Redundancy
d. Pleiotropy

A

d

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4
Q

An Ig test with antibodies to detect CD3 will detect which cell

a. Circulating T cells
b. T helper lymphocytes only
c. T Suppressor lymphocytes only
d. NK Cells

A

A
- Surface marker found on ALL T cells
- Associated with T-Cell antigen receptor

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5
Q

Cryoprecipitate AHF contains all of the following Except:

a. RBC
b. Fibrinogen
c. vWF
d. Fibronectin

A

a

At least 80 unit of AHF 150 mg of fibinogen
FXIII vWF Fibronnectin

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6
Q

Which minor blood group system can cause HDN?

a. Vel
b. Gregory
c. Gerbich
d Holley

A

A or C

Gerbich
- Some IgM, most IgG
- Sometimes Clinically significant, sometimes not
- Anti-Ge3: implicated to cause serious HDFN

Vel
- Most IgG and some IgM
- activates Complement; causes in vitro and in vivo hemolysis
- Caused severe, immediate HTRs and one cause of severe HDFN

If Boards = Go with Gerbich

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7
Q

ABO discrepanicies between forward or reverse blood typing with weak reacting or missing Ab

a. Patient with antibody to wak antigen
b. Patient is very young or old
c. Patient with subgroup of A or B
d. Patient with acquired phenomenon

A

b

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8
Q

Lectin Dolichos biflorus expresses ___ antigen

a. A1
b. K
c. P
d. I

A

a

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9
Q

Red cell immune antibody

a. IgG
b. IgA
c. IgD
d. IgE

A

a

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10
Q

The following are correct for the storage and transport of blood comp except
a. Hygeinc environment
b. Stored at -20 C
c. Not be hemolyzed
d. must be protected from breakdown products of glycerol

A

b

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11
Q

Rh blood group:

a. Glycosylated protein
b. Non-glucosylated protein
c. Carbs
d. Glycolipids

A

b

Rh antigen are non glycosylated protein No Carbs

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12
Q

Delayed transfusion reaction, Except:

a. Hemolytic
b. TA-GVHD
c. PTP
d. Hemosiderosis

A

D

least likely cause of a delayed transfusion reaction

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13
Q

Improved methodology referring to non-valued added activities as waste

a. Lean
b. Scrum
c. Agile
d. Waterfall

A

a

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14
Q

The Red cell phenotype of an individual in routine forward and reverse group with the genotypes hh, AB

a. AB
b. O
c. A
d. B

A

b

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15
Q

Which type of hypersensitivity reaction involves immune complexes

a. Type 1
b. Type 2
c. Type 3
d. Type 4

A

c

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16
Q

CD8+

a. Helper
b. Killer
c. Null
d. Cytotoxic

A

d with T suppressor

CD4- T regulator
NK (Large granular lymphocytes) = CD 16 . CD 56

17
Q

Anti-G will not react to the following except

a. D+ C+
b. D- C-
c. D+ C-
d. D- C+

A

a

G-antigen
- Ag present on most D+ and all C+ RBCs
- In Ab identification testing, anti-G reacts as though it is a combination of Anti D and anti-C

18
Q

Blood group enhanced by enzyme:

a. Kell
b. Kidd
c. MN
d. Duffy

A

b

MN, Duffy, and Kell are destroyed by enzymes treatment

19
Q

FFP is used to treat the following Except:
a. DIC
b. Liver disease
c. Vitamin K Deficiency
d. Idiopathic Thrombocytopenic purpura

A

D

20
Q

What is the percentage of mother-fetus incompatibility if father is Rh+, mother is Rh-? The have their fist child without undergoing treatment

a. 0%
b. less than 50%
c. 50%
d. 100%

A

B

If the father is Heterozygous \

If father is Homozygous = 100%

21
Q

Component only found in the alternative pathway

a. C4
b. C1q
c. Properdin B
d. C3

A

C

22
Q

What is detected by the flocculation test for syphilis?

a. Cadriolipin
b. Reagin
c. Treponemal antigen
d. Treponemal Ab

A

b

23
Q

Which cluster of differentiation marker appears during the fist stage of T cell development and remains present as an identifying marker for T cells

a. CD 1
b. CD 2
c. CD 3
d. CD 4 or CD 8

A

c

24
Q

Most common form of autoimmune hemolytic anemia and involves IgG autoantibodies and has optimal reactivity at 37 C

a. WAIHA
b. CAIHA
c. Drug induced Autoimmune hemolytic anemia
d. Aplastic anemia

A

a

25
Q

Indirect marker for fibrinogen

a. Hemoglobin
b. CRP
c. SLE
d. ESR

A

D
Plasma protein that can affect ESR

26
Q

Which of the followin is correct:

a. Northern Blot: DNA
b. Northern Blot: RNA
c. Souther Blot: DNA
d. Southern blot: RNA

A

B or C

S D
N R
o o
W P

27
Q

Cell mediated immunity

a. B cell
b. T cell
c. T helper
d. Dendritic cell

A

b

28
Q

All are correct regarding Sabin Feldman Dye test, Except:

a. I t uses live toxoplasma
b. It uses dead Toxoplasma
c. It is a neutralization reaction
d. It is sensitive and specific test for Toxoplasmosis

A

b

  • Reference serologic test
  • Sensitive and specific neutralization test
  • Uses live toxoplasma
29
Q

Hepatitis profile

HBsAg (-)
Anti-HBc (-)
Anti-HBs (+)

a. Chronic
b. Past
c. Active
d. Immunization

A

d

30
Q

Which of the following should have deferral

a. Antibiotic
b. Birth Control pills
c. Hepatitis Vaccination
d. Blood pressure medication
.

A

a

Hepatitis vaccination have no Deferral due to its composition

31
Q

Immunoglobulin Present in B cells

a. IgA
b. IgM
c. IgG
d. IgE

A

b

32
Q

Measure total serum IgE

a. IFA
b. RAST
c. RIST
d. EIA

A

c

RAST = Allergen Specific IgE
RIST = Total Serum IgE

33
Q

Lectin that detec H antigen

a. Dolichus biflorus
b. Ulex europaues
c.
d.

A

b

34
Q

Patient with very low fibrinogen and DIC may be given which blood product?

a. WB
b. pRBCs
c. Cryoprecipitate
d.FFP

A

c

Has the highest concentration of FI

35
Q

Which serum Ab response usually characterized the primary or early stage of sypjilis

a. Ab against syphilis are undetectable
b. Detected 1-3 Weeks after appearance of the primary chancre
c.
d.

A

bWhich tests

36
Q

Which tests are considered screening tests for HIV?

a. ELISA, 4th Gen, and Rapid Ab test
b.
c.
d.

A

a

37
Q

Involeved in inflammation

a. Serotonin
b. Acetylcholine
c. Dopamine
d. Prostaglandin

A

d

38
Q

What to check during blood donation Except:l

a. Donor hyperventilating
b. Change in Blood flow
c. Hematoma formation
d Wounds in the arms and legs of donor

A

d

39
Q

Immunity induced by toxoid administration:

a. Natural active
b. Natural passive
c. Artificial active
d. artificial passive

A

c