CC Part 2 Flashcards

1
Q

When referring to quality control results what parameter usually determines the acceptable range?

a. The 95% confidence interval for the man
b. The range that includes 50% of the results
c. The central 68% of results
d. The range encompassed by +_1 Standard deviations

A

a

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2
Q

Which of the following QC rules would be broken 1 out of 20 times by chance alone?

a. 12s
b. 22s
c. 13s
d. 14s

A

a

When establishing new Reference range, 120 people are variables that are healthy

in 95%, the remaining 5% is the 12s

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3
Q

The lean seix Sigma quality improvement methodology includes all of the following except:

a. Define
b. Measure
c. Analyze
d. Communicate

A

d

Lean - a matter of reducing waste
SS - Reduction of errors

DMAIC

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4
Q

A trend in QC results is most likely caused by:

a. Deterioration of the reagent
b. Miscalibration of the instrument
c. Improper Dilution of standards
d. Electronic noise

A

A

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5
Q

Which plot will give the earlies indication of a shift or trend

a. Levy-Jenning
b. Tonks-Youden
c. Cusum
d. Histogram

A

C

a. - Detects errors
b. Used to compare 2 lab
c - Cumulative sum graph
d - Histopath for MCV

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6
Q

The extent to which measurement agree with the true value of the quantity being measured is known as?

a. Acceptable limits
b. Accuracy
c. Precision
d. Reliability

A

B

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7
Q

Which of the following would be most adversely affected by a non-fasting sample?

a. HDL
b. LDL
c. Cholesterol
d. Triglycerides

A

d

Endo = VLDL
Exo = Chylomicrons (Derive from the diet which is the most affected)

A. and B. Not directly affected long term

C. Cholesterol is very general

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8
Q

A nurse calls the laboraroty technologist on duty asking about blood collection fro the analysis of enzymes. Which of the following tubes would you suggest the technologist collect?

a. Red Top
b. EDTA
c. Oxalate
d. Fluoride

A

a

Enzymes = Cofactors (Accelerator)

b- Chelates calcium
c and d. Chelates ions

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9
Q

According to NCEP, which lipid or lipoprotein class is more important for therapeutic decision making (Diet and Medication Decisions)

a. Chylomicrons
b. LDL
c. HDL
d. Cholesterol

A

B

HDL contains cardioprotective however it does not collerate disease such as CAD which is why LDL is used

As LDL increase You can predict CAD

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10
Q

A patient sample is assayed for dasting Triglyceriudes and a triglyceride value of 1036 mg/dL, this is of immediate concern because of its association with chich of the following conditions

a. CAD
b. Diabetes
c. Pancreatitis
d. Gout

A

c

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11
Q

Which of the following apoproteins is inversely related to risk for coronary hear disease and is surrogate marker for HDL

a. APO A-1
b. APO B
c. APO B100
d. APO E

A

a

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12
Q

A plasma glucose result is 100mg/dl, the corresponding glucose in whole blood would approximate:

a. 58 mg/dL
b. 87 mg/dl
c. 98 mg/dL
d. 114 mg/dL

A

b

Whole blood is lower 10-15% than in plasma

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13
Q

The red complex developed in the Jaffe method to determine Creatinine measurements is a result of the complexing of creatinine with which of the following?

a. Alkaline picrate
b. Diacetyl monoxide
c. Sulfuric acid
d. Sodium hydroxide

A

a

B. - DAM U (Uric acid)
C
D. Incomplete answer

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14
Q

Which of the following enzymes catalyzed the conversion of PNPP to a colored P-nitrophenol product?

a. AST
b. ALT
c. ALP
d. GGT

A

C

PNPP

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15
Q

Which of the following conditions can physiologically elevate serum ALP

a. Hyperparathyroidism
b. Diabetes
c. Third - Trimester Pregnancy
d. Nephrotic syndrome

A

c

NORMAL

BLIP ( In reverse) (4 Major fractions)

Heat Denaturation: PILB (From most stable to Least)
Electrophoresis: IPBL (From Cathode to anode)

Placental

Intestine

Liver

Bone

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16
Q

Which ofthe following is the most likely to produced plasma potassium result

a. Hypoparathyroidism
b. Cushing’s Syndrome
c. Diarrhea
d. Hemolysis

A

d

17
Q

Which of the following electrolytes is the chief plasma cation whose main function is maintaining osmotic pressure

a. Chloride
b. Potassium
c. Sodium
d. Bicarbonate

A

C

18
Q

Which of the following conditions will elevate ionized calcium?

a. DM
b. Hyperlipidemia
c. Acidosis
d. Alkalosis

A

C

Leaching effect - Too much acid which affects the bone

19
Q

Which of the followin enzymes is activated by Calcium Ions?

a. CK
b. Amylase
c. ALP
d. LD

A

B

Amylase is activated by calcium ANG Cl (The only enzyme that activated by ANION)

20
Q

Which of the following enzymes is common to all enzymatic methods for Triglyceride measurement?

a. Glycerol phosphate oxidase
b. Glycerol Phosphate dehydrogenase
c. Glycerol kinase
d. Pyruvate kinase

A

C

Bacterial
1. Lipase
2. Glycerol kinase
1 and 2 - are most common enzymes to all tri
3.
4.

21
Q

Which enzyme is measured in WB

a. Chymotrypsin
b. G6PD
c. Glycogen Phosphorylase
d. Lipase

A

b

G6PD = Hexokinase / PPP (Product is NADPH to reduce glutathione)

22
Q

Select te order of mobility of lipoproteins electrophoresed on cellulose acetate or agarose at pH 8.6

a. Chlyo > Pre Beta > beta > Alpha
b. Beta >Pre-Beta> Alpha> Chylo
c. Chlyo > Beta > Pre beta > Alpha
d. Pre Beta >Beta> Alpha> Chylo

A

c

Beta = LDL
Pre beta = VLDL
Alpha = HDL

23
Q

In Cirrhosis, A predominant characteristics observed in Electrophoretic serum pattern is:

a. Increase in A2-Globulins
b. Bridging effect between Beta and Gamma Globulin Fraction
c. Monoclonal band in Gamma Globulin region
d. Polyclonal band in Gamma Globulin Region

A

b

Cirrhosis is a chronic inflammation, which will send plasma cells to the liver which increases the gamma region

24
Q

Increased Intravascular hemolysis is indicated by a decrease in

a. Haptoglobin
b. Methemoglobin
c. Albumin
d. Hemopexin

A

a

Haptoglobin will decrease since hemoglobin will bind to it

IF CHRONIC = Hemopexin is increased

25
Q

The sample of Choice for measuring Blood Osmolality
a. Serum
b. Plasma
c. Whole Blood
d. Serum or plasma may both be used

A

a

26
Q

Seleect the most appropriate single screenign test for thyroid disease

a. FTI
b. TSH
c. Total T3
d. Total T4

A

b

Hperthyroidisim = T4

27
Q

Hyperaldosteronism will cause _________ serum sodium and _____ Serum potassium levels

a. Increased ; Decreased
b. Increased; Increased
c. Decreased ; Increased
d. Decreased ; decreased

A

a

Also known as conn’s syndrome

Aldosterone Reabsorbed sodium in DT whihc causes Hypernatremia and hypokalemia

28
Q

a blood alcohol level of 0.35-0.50% is associated with:

a. Unable to stand/Walk, Vomiting and impaired consiousness
b. Decreased inhibitions, loss of critical judgment, memory impairment and decrased reaction time
c. Coma and possible death
d. mild. euphoria, Decreased inhibitions, and some impairment of motor skills

A

C

0.01-0.05% = No obvious impairment
0.03 - 0.12 % = D
0.09 - 0.25% = B
0.18 - 0.30% = Mental confusion, dizziness, strongly impaired motor skills
0.27 - 0.40 % = Unable to stand/Walk , Vomiting, and impaired consiousness
0.35 - 0.50% = Coma and possible death

29
Q

Prerenal azotemia is caused by:

a. Acute renal failure
b. Chronic renal failure
c. Congestive heart failure
d. Urinary Tract obstruction

A

C

PRERENAL not part of Renal (Before)

30
Q

Convert 34.8 C to F

a. 94.7
b. 105.2
c. 34.8
d. 72.3

A

a

F = (c x 1.8 or 9/5) + 32

37.5 C = 110 F

31
Q

Which of the following chemistry analyzers uses “Slides” to contain the entire reagent syste,?

a. Vitros
b. ACA
c. Paramax
d. Coulter

A

A

Brand that uses Slide

32
Q

Which of the following values is considered to be the safest Blood lead level?

a. 0.5 MCG/DL
b. 1.0 MCG/DL
c. 10.0 MCG / DL
d. 0 mcg/dL

A

d

Lead is basically not safe (SAFEST) PUSA Just use common sense

0.5-1.0 Is the Threshold

33
Q

Hypokalemia may be caused by each ofthe following except:

a. Acidosis
b. Prolonged vomiting or diarrhea
c. Hypomagnesemia
d. Hyperaldosteronism

A

A

Hydrogen ions exchange (Meaning Hydrogen in which decreases hydrogen = Acid, Potassium out which is increased)

Prolonged vomiting = Decreased in potassium (Remember that ma K is seen in Gastric fluid

34
Q

The normal ratio of Carbonic acid to Bicarbonate in Arterial Blood is:

a. 7.4:6.1
b. 20:1
c. 0.00004:1.39
d. 1:20

A

D

Carbonc : Bicarbonate

Bicarbonate should be many in the body

35
Q

Which of the following is the primary mechanism of compensation for metabolic acidosis:

a. Hyperventilation
b. Hypoventilation
c. Aldosterone Release
d. Bicarbonate Excretion

A

a

Least effective compensatory mechanism IS B due to requirement of Breathing

Adrenal Gland hormone: Mnemonics
G (Zona Glomerulosa) > M (Aldosterone)
F (Zona Fasiculata) > G (Cortisol)
R (Zona Reticularis) > Sex steroid