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finals > IS: Diseases and Sero tests > Flashcards

IS: Diseases and Sero tests Flashcards

1
Q

are self-replicating extrachromosomal dna molecules that are located in the bacteria’s cytoplasm and contain limited number of genetic elements

A

Plasmid

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2
Q

Found on the cell wall of gram - bacteria

A

Lipopolysaccharide

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3
Q

Function in the attachment of bacteria to host cell

A

F or sex pili

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4
Q

enhance ability of S. pyogenes pili to attach to host cell particularly to fibronectin

A

F protein

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5
Q

limits deposition of C3 on the bacterial surface

A

M protein

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6
Q

Proteins excreted by bacterial cells as they metabolize during course of strep infections

A

exoantigens/exotoxins

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7
Q

strep enzyme that promotes fibrinolytic activity by converting plasminogen to plasmin

A

streptokinase

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8
Q

enhances spread of streptococcus through connective tissue

A

hyaluronidase

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9
Q

inactive in the oxidized form and can cause lysis of wbc and rbc in its reduced state

A

Streptolysin 0

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10
Q

MW of streptolysin O

A

70 000 daltons

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11
Q

produces surface hemolysis on BAP and is non antifenic with 2800 MW

A

Streptolysin S

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12
Q

result of pharyngeal infection; URTI with rash due to erythrogenic toxin

A

Scarlet Fever

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13
Q

very red and swollen and there is well-defined border btwn normal and infected skin

A

Erysipelas/St. Anthony’s fire

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14
Q

skin infection that invades muscles of extremities or trunk

exotoxins deep in fascia result in ischemia, tissue necrosis, and sepsis

A

necrotizing fasciitis

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15
Q

main damaging sequelae of group a strep

A

glumerulonephritis
Acute RHF

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16
Q

strep is plated on

A

blood agar

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17
Q

ASO titer for children in ASOT testing

A

360 Todd units

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18
Q

positive result in anti-dnase test

A

green color persists

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19
Q

MOT of H. pylori

A

fecal-oral, oral-oral

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20
Q

urea is broken down to what in urea breath test

A

ammonia and bicarbonate

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21
Q

used to determine success of therapy in h. pylori

A

rapid EIA

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22
Q

best for initial screening method

A

anti H. pylori detection/ ELISA

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23
Q

mulberry//fried egg appearance in culture

A

M. pneumoniae

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24
Q

2 syndromes caused by M. pneumoniae

A

Reynaud’s syndrome
Stevens-Johnson syndrome

25
Q

rash appear first on trunk and later to extremities

A

Thypus group

26
Q

Rocy mountain spotted fever is caused by

A

Rickettsia ricketsii

27
Q

Rocky mountain fever is transmitted by

A

american dog tick (D. variabilis),
wood tick (D. andersoni)
brown dog tick (R. sanguineus)

28
Q

target cell of rocky mountain fever

A

vascular endothelium

29
Q

method of choice for rickettsial infection

A

serodiagnosis

30
Q

gold standard in derecting rickettsial antibodies

A

IFA
micro IF

31
Q

long slendel helically coiled microaerophilic bacteria that has periplasmig flagella and corkscrew movement

A

spirochetes

32
Q

pinta is caused by

A

T. carateum

33
Q

t. pallidum s. pallidum is best observed in

A

DFM

34
Q

evolves from macule to papula and into ulcer

firm painless non itchy skin ulceration

A

chancre

35
Q

patches that become maculopapular forms white flat whitish wart like lesions

A

condylomata lata

36
Q

tabes dorsalis in tertiary stage of syphilis means

A

general paralysis

37
Q

chronic skin and bone disease of tropics with fambresia lesions

A

yaws

38
Q
A
39
Q

buba causative agent

A

T. pallidum s. pertenue

40
Q

this test reacts with cardiolipin

A

non trep test

41
Q

false positive in non trep test occurs in diseases such as

A

hepa, im, measles

42
Q

VDRL,RPR,ISR are examples of

A

non trep test

43
Q

only sero test approved for diagnosing neurosyphilis

A

vdrl

44
Q

removes anti-complement property of cardiolipin

A

lecithin

45
Q

preservative used in rpr

A

thimerosal

46
Q

trep test that is test of choice for neurosyphilis and rule out false pos result

A

TPI test

47
Q

uses reiter strain and nichols strain

A

FTA-ABS

48
Q

diag of neurosyphilis in aids ptx

A

pcr

49
Q

microhemagglutinaton uses

A

formalinized tanned sheep rbc

50
Q

hatta and tpha

A

gluteraldehyde stabilized sheep rbc

51
Q

pos result for this is lattice-like structure covering surface of well, used to detect primary syphilis and uses gelatin

A

TP-PA

52
Q

5-30 um long, 0.2-0.5 um wide and contain 7-22 periplasmig flagella

A

Borrelia spp

53
Q

vector-borne multisystem illness involving skin, nervous system heart and joints

A

lyme disease

54
Q

causative agent for lyme disease

A

borrelia burgdorferi sensu stricto

55
Q

ixode in west us

A

i. pacificus

56
Q

main reservoir host of borrelia

A

white footed mouse / peromyscus leucopus

57
Q

bull’s eye lesion

A

erythema chronicum migrans or ECM in stage 1 lyme disease

58
Q

arthritis, late neuroborreliosis

A

late lyme disease/stage 3

finals (10 decks)

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