Hematology: Malignant Myeloproliferative DIsorders Flashcards
with dysgranulopoiesis and dysmegakaryopoiesis
RAEB
RARS is similar to RA except
RARS have phatologic ringed sideroblasts
clonal hematopoietic neoplasms characterized by **cytopenias **due to ineffective hematopoiesis and increased apoptosis
Myelodysplastic Syndromes
the three abnormalities found in PB and BM in MDSs
- dyserythropoiesis
- dysgranulopoiesis
- dysmegakaryocytopoiesis
AML subgroup that stains negatively with MPO and SBB
M0
neutropinia, anemia, and thrombocytopenia is a lab finding in _____?
Acute Myeloid Leukemia
unregulated proliferation of the myeloid stem cell
AML
Acute Myeloid Leukemia
FAB classification of DMPS where anemia is not responsive to therapy
Refractory Anemia
chromosome abnormality is t(15-17)
M3 (APL)
DMPS where there is impaired hemoglobinization of RBC
RARS
highest degree of skin and tounge disease involvement, bcs of migration of leukocytes
M3 (APL)
DMPS where there is dyspoiesis, presents with leukocytosis (WBC >100x109/L)
CMML (Chronic Myelomonocytic Leukemia)
in the laboratory findings of this anemia, absolute reticulocytopenia is found
RA/RC
also called Naegeli leukemia
predominance of myeloblast nds myelocyte
M4 (AMML)
Also known as* Schilling’s Leukemia*
M5 (AMoL)
Megakaryocytic Leukemia is only positive in what cytochemical stain?
ANAE
DMPS where there is presence or absence of auer rods
RAEBIT
Presents with pancytopenia and bleeding
M7 (AMegL)
2 subgroups of AML that comprises 30% relative frequency
M2, M4
AML where predominant cell is poorly differentiated myeloblast without granulations
M1 (Myeloblastic anemia with minimal maturation
Auer rods are predominantly seen in
myelobasts or promyelocytes
High risk of developing into AML
RAEBIT
the mildest form of DMPs
RA/RC
In RAEB and M2, how are they differentiated
M0 have auer rods
derivative of azurophilic granules, stains positively for MPO, SBB, and CAE
Auer rods
Chromosome abnormality is t(15-17) and predominantly associated with** DIC** (thromboplastin)
M3 (APL)
gum hypertrophy and infiltration, rectal ulceration, skin involvement
M4 (AMML)
MPO and SBB stain positive in M0? True or False.
False.
the one MDS that usually presents with leukocytosis
CMML
(Chronic Myelomonocytic Leukemia)
associated with chromosome abnormality t(8,21)
M2 (Myeloblastic Leukemia with maturation)
anemia is refractory, no dysgranulopoiesis, no dysmegakaryopoiesis
RA/RC
Laboratory findings include Philadelphia chromosome; normocytic normochronic anemia
Chronic Myelogenous Leukemia (CML)
Philadelphia chromosome is a translocation in what two chromosome
t(9,22)
Proliferation of granulocytic, erythrocytic, and megakarocytic series seen in spleen, liver, and lymph nodes
also has presence of teardrop RBC, blood picture (nRBC+immature WBC+ab platelets)
Primary Myelofibrosis
Proliferation of megakaryocytes; increase in platelet mass w/out accompanying significant erythrocytosis. Many giant and bizarre forms of platelets.
platelet count >600 x 109/L
Essential Thrombocytopenia
Rarest of the chronic MPDs, high LAP score
Chronic Neutrophilic Leukemia
mildest form of DMPS
RA/RC
dimorphic anemia (hypochromic microcytes and oval macrocytes)
RARS
with dysgranulopoiesis and dysmegakaryopoiesis
RAEB
the one MDS that usually presents with leukocytosis
CMML
presence/absence of auer rods
RAEBIT
linear, spindle-shaped, red-purple inclusions
Auer rods
Auer rods seen in
myeloblasts promyelocytes
frequently assoc w DIC
M3 (APL)
FAGGOT CELLS
M3
erythrocytes have nRBCs and HJ bodies
leukomoid reax vs cml
cml
increase in all cell line
PV
