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finals > Hematology: Malignant Myeloproliferative DIsorders > Flashcards

Hematology: Malignant Myeloproliferative DIsorders Flashcards

1
Q

with dysgranulopoiesis and dysmegakaryopoiesis

A

RAEB

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2
Q

RARS is similar to RA except

A

RARS have phatologic ringed sideroblasts

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3
Q

clonal hematopoietic neoplasms characterized by **cytopenias **due to ineffective hematopoiesis and increased apoptosis

A

Myelodysplastic Syndromes

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4
Q

the three abnormalities found in PB and BM in MDSs

A
  1. dyserythropoiesis
  2. dysgranulopoiesis
  3. dysmegakaryocytopoiesis
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5
Q

AML subgroup that stains negatively with MPO and SBB

A

M0

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6
Q

neutropinia, anemia, and thrombocytopenia is a lab finding in _____?

A

Acute Myeloid Leukemia

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7
Q

unregulated proliferation of the myeloid stem cell

A

AML
Acute Myeloid Leukemia

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8
Q

FAB classification of DMPS where anemia is not responsive to therapy

A

Refractory Anemia

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9
Q

chromosome abnormality is t(15-17)

A

M3 (APL)

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10
Q

DMPS where there is impaired hemoglobinization of RBC

A

RARS

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11
Q

highest degree of skin and tounge disease involvement, bcs of migration of leukocytes

A

M3 (APL)

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12
Q

DMPS where there is dyspoiesis, presents with leukocytosis (WBC >100x109/L)

A

CMML (Chronic Myelomonocytic Leukemia)

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13
Q

in the laboratory findings of this anemia, absolute reticulocytopenia is found

A

RA/RC

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14
Q

also called Naegeli leukemia

predominance of myeloblast nds myelocyte

A

M4 (AMML)

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15
Q

Also known as* Schilling’s Leukemia*

A

M5 (AMoL)

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16
Q

Megakaryocytic Leukemia is only positive in what cytochemical stain?

A

ANAE

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17
Q

DMPS where there is presence or absence of auer rods

A

RAEBIT

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18
Q

Presents with pancytopenia and bleeding

A

M7 (AMegL)

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19
Q

2 subgroups of AML that comprises 30% relative frequency

A

M2, M4

20
Q

AML where predominant cell is poorly differentiated myeloblast without granulations

A

M1 (Myeloblastic anemia with minimal maturation

21
Q

Auer rods are predominantly seen in

A

myelobasts or promyelocytes

22
Q

High risk of developing into AML

A

RAEBIT

23
Q

the mildest form of DMPs

A

RA/RC

24
Q

In RAEB and M2, how are they differentiated

A

M0 have auer rods

25
Q

derivative of azurophilic granules, stains positively for MPO, SBB, and CAE

A

Auer rods

26
Q

Chromosome abnormality is t(15-17) and predominantly associated with** DIC** (thromboplastin)

A

M3 (APL)

27
Q

gum hypertrophy and infiltration, rectal ulceration, skin involvement

A

M4 (AMML)

28
Q

MPO and SBB stain positive in M0? True or False.

A

False.

29
Q

the one MDS that usually presents with leukocytosis

A

CMML
(Chronic Myelomonocytic Leukemia)

30
Q

associated with chromosome abnormality t(8,21)

A

M2 (Myeloblastic Leukemia with maturation)

31
Q

anemia is refractory, no dysgranulopoiesis, no dysmegakaryopoiesis

A

RA/RC

32
Q

Laboratory findings include Philadelphia chromosome; normocytic normochronic anemia

A

Chronic Myelogenous Leukemia (CML)

33
Q

Philadelphia chromosome is a translocation in what two chromosome

A

t(9,22)

34
Q

Proliferation of granulocytic, erythrocytic, and megakarocytic series seen in spleen, liver, and lymph nodes

also has presence of teardrop RBC, blood picture (nRBC+immature WBC+ab platelets)

A

Primary Myelofibrosis

35
Q

Proliferation of megakaryocytes; increase in platelet mass w/out accompanying significant erythrocytosis. Many giant and bizarre forms of platelets.

platelet count >600 x 109/L

A

Essential Thrombocytopenia

36
Q

Rarest of the chronic MPDs, high LAP score

A

Chronic Neutrophilic Leukemia

37
Q

mildest form of DMPS

A

RA/RC

38
Q

dimorphic anemia (hypochromic microcytes and oval macrocytes)

A

RARS

39
Q

with dysgranulopoiesis and dysmegakaryopoiesis

A

RAEB

40
Q

the one MDS that usually presents with leukocytosis

A

CMML

41
Q

presence/absence of auer rods

A

RAEBIT

42
Q

linear, spindle-shaped, red-purple inclusions

A

Auer rods

43
Q

Auer rods seen in

A

myeloblasts promyelocytes

44
Q

frequently assoc w DIC

A

M3 (APL)

45
Q

FAGGOT CELLS

A

M3

46
Q

erythrocytes have nRBCs and HJ bodies

leukomoid reax vs cml

A

cml

47
Q

increase in all cell line

A

PV

finals (10 decks)

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