Iron Overload

Question 1

What highly reactive radical is formed as a result of unbound iron?

Answer 1

OH (Hydroxyl radical)

Question 2

What are the results of unbound iron?

Answer 2

Lipid peroxidation, Fibrosis, Carcinogenesis

Question 3

Does Iron overload occur in chronic alcoholics?

Answer 3

Yes, about 30% of the time

Question 4

What are the possible alcohol effects with iron?

Answer 4

Iron content in red wines, folate deficiency increases iron absorption

Question 5

What are the clinical presentations of iron with alcoholic liver disease?

Answer 5

Skin pigmentation, hypogondism, glucose intolerance, iron in more of the kupffer cells than hepatocytes

Question 6

What is a risk of treating Thalassemia with transfusion or iron supplements?

Answer 6

Iron Overload

Question 7

What are the clinical problems of Thalassemia and Iron Overload?

Answer 7

1st decade with hepatomegally, lack of sexual development, 2nd decade - cardiomegally