Cancer Drug Toxicities and MOA

Question 1

Pulmonary Fibrosis

Answer 1

methotrexate and bleomycin

Question 2

what can’t be given w/ fludarabine

Answer 2

pentostatin

Question 3

hemorrhagic cytitis

Answer 3

cyclophosphamide and ifosphamide

Question 4

CV toxicity

Answer 4

anthracycline, arsenic, nilotinib, mitoxantrone, IFN 2 alpha beta

Question 5

Neuropathy

Answer 5

vins

Question 6

leukocytosis

Answer 6

ATRA and arsenic

Question 7

hyperuricemia

Answer 7

bendamustine

Question 8

infusion

Answer 8

mabs and bendamustine

Question 9

birth defects

Answer 9

thalidomide, imatinib, hydroxurea

Question 10

exfolative dermatitis

Answer 10

rituximab, ibrutimomab, metho

Question 11

hepatic disease

Answer 11

dacarbazine and anthracyclines

Question 12

TPMT genotyping

Answer 12

6MP and TG

Question 13

Pregnancy contraindication

Answer 13

chlorambucil, dacarbazine, mechlorethamine

Question 14

MOA for cyclophosamide

Answer 14

cell cycle inhibitor

Question 15

Side effects for cyclophosamide

Answer 15

renal failure, hematuria, hemorrhagic cystitis

Question 16

MOA for dacarbazine

Answer 16

methylating agent on )6

Question 17

Metho MOA

Answer 17

DHFR inhibitor

Question 18

Cytarabine MOA

Answer 18

inhibits chain elongation

Question 19

6MP MOA

Answer 19

has some effects on HGPRT

Question 20

Fludarabine MOA

Answer 20

ribonulceotide reductase inhibitor

Question 21

anthracyclines MOA

Answer 21

topo II enzymes

Question 22

bleomycin MOA

Answer 22

drug-Fe complex breaks DNA

Question 23

hydroxyurea MOA

Answer 23

free radical scavenger, ribonucleotide reductase inhibitor

Question 24

thalidomide MOA

Answer 24

enhances NK cell activity and peripheral neutropathy

Question 25

IFN 2ab MOA

Answer 25

induces immunologic response

Question 26

intrathecal administration = DEATH

Answer 26

vins

Question 27

hypersensitivity

Answer 27

asparaginase, carboplatin, teniposide, tositumomab, rituximab

Question 28

suicide and depression thoughts

Answer 28

IFN 2ab