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Heme > Cancer Drug Toxicities and MOA > Flashcards

Cancer Drug Toxicities and MOA Flashcards

1
Q

Pulmonary Fibrosis

A

methotrexate and bleomycin

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2
Q

what can’t be given w/ fludarabine

A

pentostatin

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3
Q

hemorrhagic cytitis

A

cyclophosphamide and ifosphamide

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4
Q

CV toxicity

A

anthracycline, arsenic, nilotinib, mitoxantrone, IFN 2 alpha beta

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5
Q

Neuropathy

A

vins

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6
Q

leukocytosis

A

ATRA and arsenic

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7
Q

hyperuricemia

A

bendamustine

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8
Q

infusion

A

mabs and bendamustine

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9
Q

birth defects

A

thalidomide, imatinib, hydroxurea

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10
Q

exfolative dermatitis

A

rituximab, ibrutimomab, metho

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11
Q

hepatic disease

A

dacarbazine and anthracyclines

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12
Q

TPMT genotyping

A

6MP and TG

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13
Q

Pregnancy contraindication

A

chlorambucil, dacarbazine, mechlorethamine

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14
Q

MOA for cyclophosamide

A

cell cycle inhibitor

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15
Q

Side effects for cyclophosamide

A

renal failure, hematuria, hemorrhagic cystitis

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16
Q

MOA for dacarbazine

A

methylating agent on )6

17
Q

Metho MOA

A

DHFR inhibitor

18
Q

Cytarabine MOA

A

inhibits chain elongation

19
Q

6MP MOA

A

has some effects on HGPRT

20
Q

Fludarabine MOA

A

ribonulceotide reductase inhibitor

21
Q

anthracyclines MOA

A

topo II enzymes

22
Q

bleomycin MOA

A

drug-Fe complex breaks DNA

23
Q

hydroxyurea MOA

A

free radical scavenger, ribonucleotide reductase inhibitor

24
Q

thalidomide MOA

A

enhances NK cell activity and peripheral neutropathy

25
Q

IFN 2ab MOA

A

induces immunologic response

26
Q

intrathecal administration = DEATH

A

vins

27
Q

hypersensitivity

A

asparaginase, carboplatin, teniposide, tositumomab, rituximab

28
Q

suicide and depression thoughts

A

IFN 2ab

Heme (38 decks)

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