Antiplatelet Drugs and Thrombolytics Flashcards

1
Q

What are non selective COX inhibitors?

A

aspirins and NSAIDS

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2
Q

What are selective COX2 inhibitors?

A

Celecoxib and Celebrex

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3
Q

What are COX3 inhibitors?

A

Acetaminophen (Tylenol)

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4
Q

What are PDE inhibitors?

A

dypridamole, and cilostazol

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5
Q

What are P2Y12 platelet receptor inhibitors (ADP receptor Antagonists)?

A
oral thienopyridines (grels)
- Clopidogrel and Prasugrel
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6
Q

What are Gp IIb/IIIa receptor antagonists?

A
  • Synthetic peptides –> eptifibidate

- Antibodies –> abciximab

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7
Q

What are thrombolytic drugs?

A

streptokinase, urokinase, tPA, reteplase

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8
Q

What are fibrinolytic inhibitors?

A

Aminocaproic acid

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9
Q

What does inhibition of COX1 in platelets do?

A

prevents synthesis of Thromboxane

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10
Q

What is aspirin’s MOA? what effect does it have on platelets?

A
  • it acetylates COX-1
  • has effect on platelets is 4-7 days, inactivates platelets for their lifetime essentially
  • also inhibits COX2 in vascular endothelium to prevent PGI2 formation
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11
Q

What are the side effects of aspirin?

A

GI bleeding, hemorrhagic stroke, asthma

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12
Q

What is aspirin countraindicated?

A

courmarin, peptic ulcer disease, and aspirin hypersensitivity

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13
Q

Do NSAIDS have an reversible or irreversible effect on COX1/2?

A

reversible

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14
Q

Can you aspirins and NSAIDS are the same time?

A

NOOOO b/c non-selective COX inhibitors compete w/ aspirin for binding to COX.

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15
Q

What COX-2 inhibitor increases coronary heart risk?

A

Refacoxib – w/drawn from market

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16
Q

When do you only use aspirin?

A

for antiplatelet effect

17
Q

What does PDE do?

A

It converts cAMP to AMP and decreases Ca concentration w/in platelets and inhibits platelet activation and aggregation

18
Q

What else do PDE inhibitors do besides inhibiting PDE?

A

activate plateley adenylate cyclase by inhibiting adenosine uptake.

19
Q

What can dipyrdiamole do?

A

-potent vasodilator, can induce coronary steal in cardiac studies

20
Q

What are side effects of dipyrdiamole?

A

headache, dizziness, and GI upset