IPC final exam - lab values, medical records Flashcards
Laboratory values are ____ data that complement the clinical impression
SOAP
S: Subjective
O: Objective lab values in this portion
A: Assessment
P: Plan
lab data is objective data
Clinical Pearls When Interpreting Lab Data
are normal values the same between labs
do normal values vary based on age, gender, weight and height, what is an example
Laboratory errors can happen due to
technical error, what are some errors that could happen
- math
- specimen
- time
- preservative
- food substance affecting what
what should be done if lab error is expected
Normal values may vary from lab to lab depending on the techniques and reagents used
- MCPHS reference lab values document on Bb (no need to memorize it!)
Normal values may vary depending on the patient’s age, gender, weight, height
- Example: hematocrit/hemoglobin
Laboratory errors can happen due to
technical error
- improper calculation
- inadequate specimen
- incorrect sampling timing
- improper sample preservation
- food substances affecting specimen
- medication interference with lab tests
If laboratory error is suspected, the test should be repeated
Lab values present a ____ of what is going on with the ____!
what should you look for
what should you think about
Patient: 140 mEq/L, are they in the normal range for Na+
Lab values present a snapshot of what is going on with the patient!
Look at previous labs
Look at trends
Think about which labs need to be ordered
Think how frequently labs should be ordered
the normal range for Na+:
135-147 mEq/L
The PATIENT is in the normal range!
Complete Blood Count (CBC) provides values for:
Harry
Had a
White
Robe but
Molly
Made
Macaroni
Pie
Hemoglobin (Hgb)
Hematocrit (Hct)
White blood cells (WBCs)
Red blood cells (RBCs)
Mean corpuscular volume (MCV)
Mean corpuscular hemoglobin (MCH)
Mean corpuscular hemoglobin concentration (MCHC)
Platelets (Plt)
Basic metabolic panel (BMP) or Chem-7 includes:
Suzie
Plays the
Clarinet
But
Bobby plays
Chess really
Good
Sodium (Na+)
Potassium (K+)
Chloride (Cl-)
Bicarbonate (HCO3-)
Blood urea nitrogen (BUN)
Creatinine (SCr)
Glucose (Glu)
this is what the fish bone displays :)
Comprehensive metabolic panel (CMP) includes:
Ally
Always
Asks
Awesome
Thoughts
Constantly
BMP or Chem-7
Albumin
Alkaline phosphatase (ALP)
Alanine aminotransferase (ALT)
Aspartate aminotransferase (AST)
Total bilirubin
Calcium
some are liver function test
Liver function tests (LFTs) may vary slightly between labs, but generally include what molecules and tests
Always
Asks
And trust
God
Totally
Always
Pray
Intentionally
Aspartate Aminotransferase (AST)
Alanine Aminotransferase (ALT)
Alkaline Phosphatase (ALP)
gamma - Glutamyl Transpeptidase (GGT)
Total bilirubin
Albumin
PT
INR
what is Sensitivity of a test
what is a highly sensitive test
what is specificity of a test
what is a highly specific test
what is the ideal test, what are examples
how much Sensitivity & Specificity does the home pregnancy test have and if what
The sensitivity of a test is its ability to designate an individual with a disease as positive.
A highly sensitive test = with few false negative results, = and fewer cases of disease are missed
Example: COVID-19 test: Antigen test versus PCR
- so patient really has the disease
The specificity of a test is its ability to designate an individual who does not have a disease as negative.
A highly specific test = with few false positive results
Example: pregnancy test, rapid strep test
An Ideal test is highly sensitive and highly specific
Home pregnancy tests have 100% sensitivity and specificity if hCG ≥ 25 mIU/mL
- Reminder: watch the YouTube video posted on Bb
Shorthand Schematics or “Fishbones”
what molecules does it contain
what is the position of each
Hgb at the __ o’clock
Plt at __ o’clock
Hct at __ o’clock
WBC at ___ o’clock
Na, Cl, BUN in the ___ row
K, CO2 (or HCO3-), SCr in ___ row
blood glucose at far ____
and X and fishbones
with:
Hgb
Plt
Hct
WBC
memorize the position
Hgb at the 12 o’clock
Plt at 3 o’clock
Hct at 6 o’clock
WBC at 9 o’clock
Na, Cl, BUN in the top row
K, CO2 (or HCO3-), SCr in bottom row
blood glucose at far right
Causes of hypERnatremia:
- high [ ] of ___
- water
what kind of drug can cause this
Causes of hypOnatremia:
- XS of what
- what 3 diseases is associated with this
- what drug can cause this
Causes of hypERnatremia:
- ↑ Na+ intake
- Dehydration:
—-Gastroenteritis
—–Diabetes insipidus (DI)
Drugs:
- Hypertonic saline
Causes of hypOnatremia:
- Excess body water (dilutional hyponatremia),
for example:
- Heart failure
- cirrhosis
- SIADH (fluid overload)
Drugs from Top 200:
Thiazide diuretics:
- chlorthalidone
- HCTZ
Sodium (Na+) - Normal range: 135-147 mEq/L
Causes of hypERchloremia:
- water
- DI
Causes of hypOchloremia:
- puke
- SI..
- what drugs can cause this
Causes of hypERchloremia:
- Dehydration
- Diabetes insipidus
Causes of hypOchloremia:
- Prolonged vomiting (lose Cl from stomach)
- SIADH
Drugs from Top 200: Acid suppressants because they decrease HCl production:
H2 blockers:
- famotidine
PPIs:
- omeprazole, pantoprazole, esomeprazole, lansoprazole, dexlansoprazole
CHLORide (Cl-) - Normal range: 95 – 105 mEq/L .
Potassium (K+) - Normal range: 3.5 – 5 mEq/L.
Causes of hypERkalemia:
- what organ failure
- water
- massive ____ damages from what
- what about the blood specimen
what Drugs from Top 200 can cause this
Causes of hypOkalemia:
- lose of what
what Drugs from Top 200 can cause this
Causes of hypERkalemia:
- Renal failure
- Dehydration
- Massive cell damage: burns, injuries
- Hemolyzed blood specimen (falsely elevated)
Drugs from Top 200:
- ACEIs: quinapril, Ramipril, benazepril, enalapril, lisinopril
- ARBs: losartan, valsartan, irbesartan
- Potassium-sparing diuretics: Spironolactone
- Others drugs: Potassium supplements
Causes of hypOkalemia:
- Severe diarrhea and/or vomiting
Drugs from Top 200:
- Thiazide diuretics: chlorthalidone, HCTZ
- Loop diuretics: furosemide
CO2 content or HCO3- Normal range 22 – 28 mEq/L
Causes of increased CO2 content
- metabolic what
Causes of decreased CO2 content
- metabolic what
what Drugs from Top 200 can cause this
CO2 content vs CO2 gas (lungs; acidic)
Causes of increased CO2 content
- Metabolic alkalosis
Causes of decreased CO2 content
- Metabolic acidosis
Drugs:
- salicylate toxicity
Do not confuse CO2 content with CO2 gas
- CO2 content in plasma is mostly HCO3- , regulated by the kidneys, & is a base
- CO2 gas is regulated by the lungs & is acidic
Blood Urea Nitrogen (BUN) is a marker of renal function. Urea nitrogen is produced in the liver (from protein breakdown) blood cleared by kidneys (Normal range 6 – 20 mg/dL)
Causes of ↑ BUN (Azotemia)
- what organ failure
- high what diet
- water
what Drugs from Top 200 can cause this
Causes of ↓ BUN
- what organ failure
Causes of ↑ BUN (Azotemia)
- Acute or chronic renal failure
- High-protein diet
- Dehydration
Drugs that are nephrotoxic:
- From Top 200: NSAIDs ibuprofen
Causes of ↓ BUN
- Liver failure
Serum Creatinine (SCr): product of normal breakdown of muscle tissue and is excreted by glomerular filtration in the kidneys = marker of renal function (Normal range: 0.6 – 1.2 mg/dL)
Causes of increased SCr
- what organ dysfunction
- water
- workout
What drugs can cause this
Causes of decreased SCr
- muscle
Causes of increased SCr:
- Renal dysfunction
- Dehydration
- Vigorous exercise (just like for increase Hgb!)
Drugs: nephrotoxic drugs
- from Top 200:
Acyclovir, NSAIDs, cyclosporine
Causes of decreased SCr
Inactive elderly (low muscle mass)
Glucose - Normal range 70 – 99 mg/dL
Causes of hypERglycemia
- DM
- what kind of infection
What drugs can cause this
Causes of hypOglycemia
- missing what
What drugs can cause this
Causes of hypERglycemia
- Diabetes mellitus (DM)
- Sepsis - blood infection
Drugs from Top 200:
- Corticosteroids: prednisone, prednisolone, methylprednisolone
- Atypical antipsychotics: aripiprazole, risperidone, quetiapine, olanzapine
Causes of hypOglycemia
Missing a meal
Drugs from Top 200:
- sulfonylureas: glimepiride, glipizide, glyburide
- Insulin overdose
Calcium (Ca): 98-99% in skeletal bones & teeth, remainder in blood, muscles, other tissues (Total Ca normal range: 8.5 – 10.5 mg/dL)
In the blood how much calcium is in an ionized “free” state what does it do
In the blood how much calcium is bound to proteins (albumin)
what can occur due to low albumin levels
what kind of Ca2+ is usually reported in labs
In the blood
≈ half of the calcium is in an ionized “free” state exerts physiologic functions
≈ half of the calcium is bound to proteins (albumin)
Pseudohypocalcemia can occur due to low albumin levels
- calculate corrected calcium when albumin < 4 g/dL
total Ca is usually reported in labs
Corrected calcium = reported serum calcium + 0.8 (4 – patient’s albumin) - for therapeutics
Some causes of Calcium imbalance
Causes of hypERcalcemia
Drugs:
- what drug toxicity
- from top 200
Causes of hypOcalcemia
- what deficiency
- what disease
Drugs from Top 200:
Causes of hypERcalcemia
- Malignancies
Drugs:
- Vitamin D toxicity
- From Top 200: Thiazides: HCTZ, chlorthalidone
Causes of hypOcalcemia
- Vitamin D deficiency
- Renal disease
Drugs from Top 200:
- Loop diuretics: furosemide
SIADH - what is it referring to
DI - is Na+ high or low
SIADH - soaked inside
In DI, sodium is high
what % are RBC, WBCs/Plt, Plasma in spun down sample
RBCs are about ___%
WBCs and Plt about __%
plasma about ___%
what does the plasma have
RBCs are about 40-45%
WBCs and Plt about 5%
plasma about 55%
plasma has Chem-7
sodium and chloride relationship
go up together and go down together
calcium & phosphorus relationship
more calcium = less phosphate
less calcium = more phosphate
Phosphate (PO4-) - Normal range: 2.5 – 4.5 mg/dL
Causes of hypERphosphatemia
- what organ dysfunction
- increased what intake
what drugs cause this
Causes of hypOphosphatemia
- is the nutrition good
what drugs cause this
Causes of hypERphosphatemia
- Renal dysfunction
- Increased phosphate intake
Drugs:
- Increased vitamin D intake
- Laxatives
Causes of hypOphosphatemia
- Malnutrition
Drugs:
- Overuse of aluminum-containing antacids
- Overuse of calcium-containing antacids
Magnesium (Mg) - Normal range 1.5 – 2.4 mEq/L
Causes of hypERmagnesemia
- what is the one cause
What drugs cause hypermagnesmia
Causes of hypOmagnesemia
- rectal
- food
- poor
What drugs cause this
Causes of hypERmagnesemia
Renal failure
Drugs:
- Magnesium supplements
- Magnesium-containing antacids
- Magnesium-containing laxatives
Causes of hypOmagnesemia
- Diarrhea
- Vomiting
- Malabsorption
Drugs from Top 200:
- furosemide, HCTZ, chlorthiazide
- PPIs (example: omeprazole, pantoprazole, esomeprazole, lansoprazole, dexlansoprazole)
Albumin: a predominant serum-binding protein that transports various substances including medications. It is synthesized only in the liver(Normal range: 3.5 – 5 g/dL)
Causes of hypOalbuminemia
- cirrhosis in what organ
- is the nutrition good
- syndrome where
Causes of hypOalbuminemia
- Liver cirrhosis(defective synthesis)
- Malnutrition (decreased synthesis)
- Nephrotic syndrome (increased loss)
One consequence of hypoalbuminemia
One consequence of hypoalbuminemia is that drugs that are usually protein-bound become free in the plasma, allowing for higher drug levels, more rapid hepatic metabolism, or both
Complete Blood Count (CBC) Complete Blood Count (CBC)
WBC
Hgb
Hct
RBC
Reticulocytes
Red Blood Cells Indices (MCV, MCH, MCHC), Platelets
White Blood Cell (WBC) count = leukocyte count: total number of WBCs in a given volume of blood (Normal range: 3.2 – 11.3 x 103 cells/mm3)
never let monkeys eat bananas- what does each first letter indicate
Causes of increased WBCs/Leukocytosis
- what does left shift mean
- what else could be going on
drugs
Causes of decreased WBCs/Leukopenia
- what kind of therapy
never let monkeys eat bananas
- neutrophils
- lymphocytes
- monocytes
- eosinophils
- basophils
Causes of increased WBCs/Leukocytosis
- Infection
- Leukemia
“left shift” refers to infection or leukemia, increase in bands (immature neutrophils)
- Trauma, stress
Drugs from Top 200: corticosteroids: - prednisone, prednisolone, methylprednisolone
Causes of decreased WBCs/Leukopenia
Drugs:
- Chemotherapy
Red Blood Cell (RBC) count = Erythrocyte Count: Actual amount of RBCs per unit of blood (Normal range: M: 4.3 – 5.9 x 106 cells/microliter, F: 3.5 – 5 x 106 cells/microliter)
how many Hgb does a single erythrocyte have
A single erythrocyte can contain 300 million hemoglobin (Hgb) molecules, therefore, conditions that affect Hgb count will affect RBC count
Hemoglobin (Hgb) is the oxygen-carrying compound found in RBCs (Normal range for adults: M: 14 – 18 g/dL, F: 12 – 16 g/dL)
Causes of increased Hgb:
- smoking
- smokers
- gym
- mountain
- a type of cancer
Causes of decreased Hgb:
- are there enough blood cells
- is there blood retained
- having a baby?
drugs
- glucophage
- ibuprofen, naproxen pharm category
Causes of increased Hgb:
- COPD
- Chronic smokers
- Regular vigorous exercise
- Living at high altitude
- Polycythemia vera: a cancer that produces a lot of RBCs
Causes of decreased Hgb:
- Anemia
- Blood loss
- Pregnancy
Drugs from Top 200:
- Metformin
- NSAIDs (may cause bleeding): ibuprofen, naproxen, meloxicam, diclofenac, celecoxib