IPC final exam - communication Flashcards
Anticonvulsants
What are some MOAs
does t have a lot of a few indications and what are they?
MOAs
GABA (inhibitory neurotransmitter)
Ion channels (Na+, Cl-, Ca++)
Unknown
Many indications
Seizures
Migraine prophylaxis
Bipolar disorders
Weight loss
Neuropathic pain
what are the anticonvulsants
carbamazepine
Seizures are curbed
We are amazed that seizures are controlled
oxcarbazepine
Similar to carbamazepine (structural analog)
Drug interactions, MOA
Tegretol is first alphabetically, then Trileptal
Newer agent has clinical benefits
Trileptal epilepsy
Keppra
levetriacetam
Elevate seizure threshold?
No – but prevents seizures
Dilantin
phenytoin
Dilantin rhymes with “shakin’?
Lamictal
lamotrigine
Limo have shocks to prevent excessive shaking
-trigine trigger causes rash (SJS)
-motrigine no trigger does not trigger seizures (prevents)
Topamax
topiramate
Depakote
valproic acid, divalproex sodium
val vul convulsions
proex: professional at extracting seizures
kote coat protection from seizures
Neurontin and Lyrica
gabapentin and pregabalin
GABA
what is the cause of parkinson’s
what are the 2 meds for it
Neurodegenerative
Lack of dopamine
Movement issues
Chronic, progressive
Cogentin
benztropine
Anticholinergic
atropine cholinergic
Cog cog-wheel rigidity
Requip, Requip XL
ropinirole
Dopamine agonist
Rope & roll
reign in your movement
Pin & roll
pill rolling (tremor)
what anticonvulsant is used for migraines
Imitrex
sumatriptan
Serotonin Receptor Agonist
-triptans
Summa cum laude
Get rid of the migraine and you’ll be able to study and focus
Im available in other formulations for severe migraine
But NOT IM!
SC and nasal (and PO)
Imitates serotonin?
Trips up migraines?
what meds help with RA
Plaquenil
hydroxychloroquine
RA and lupus
Antimalarial
Anti-Covid?
Chronic inflammation with RA plaques in arteries
Trexall
methotrexate
RA and cancers
T-Rex + all + ate
T-Rex ate it all!
Pain & inflammation
All formulations
PO
IM, SC, IV
Intrathecal
What meds help with Parkinson’s Disease
Neurodegenerative
Lack of dopamine
Movement issues
Chronic, progressive
Cogentin
benztropine
Anticholinergic
atropine cholinergic
Cog cog-wheel rigidity
Requip, Requip XL
ropinirole
Dopamine agonist
Rope & roll
reign in your movement
Pin & roll
pill rolling (tremor)
what meds help with Psoriasis / inflammatory skin conditions
Kenalog
triamcinolone
Tri 3 indications
Psoriasis
Inflammatory skin conditions
Pruritus
-olone alone
Commercials about psoriasis show people wanting to be alone
Temovate
clobetasol
vate alleviate itching
Vacate itching
clob clobber itching
what are the types of pain
somatic pain
- musculoskeletal
- dull/achy/surgical
- local
visceral pain
- internal organs
- pressure/squeezing
- diffuse
neuropathic pain
- nerve pain
- burning, shooting, stabbing, stinging
- waves of frequency and intensity
- diffuse
what are non-pharm. treatments for pain
Rest
Ice
Compression
Elevation
RICE!
what adjuvants are good for neuropathic pain
Anticonvulsants
SSRI/SNRIs
TCAs
Good for neuropathic component of pain
what are NSAID MOA, ADRs & clinical pearls
MOA: mode of activity
Inhibit Cyclooxygenase (COX) mediated prostaglandin synthesis
Decrease immune response
Decrease inflammation, fever, pain
ADRs
GI upset/ulcers
Bleeding
Edema
Hypertension
Clinical Pearls
Take with food
Can cause kidney issues
Increased risk of MI/stroke
NSAIDs – Pregnancy and Children caution
Chronic use in women of childbearing age: linked to reversible infertility
DO NOT give during 3rd trimester
Premature closure of the ductus arteriosus and other effects
Consult with OBGYN before taking in 1st or 2nd trimester
DO NOT give to children <6 months
Other classes:
APAP: Safe in pregnancy and children of any age (Rx)
Opioids: Able to be used in pregnancy and children at any age but not preferred due to risk of addiction and neonatal withdrawal
NSAIDs memory devices
“-profen” & “-proxen”
Advil, Motrin
ibuprofen
Aleve, Naprosyn, Naprelan
naproxen
Alleviate pain
Mobic
meloxicam
Voltaren, Zipsor, Flector
diclofenac
Voltage decrease conduction of pain
Flec on your skin (patch)
Celebrex
Celecoxib
Celebrate pain relief!
Cox COX-2 selective
Opioids MOA, ADRs & clinical pearls
MOA
Mu (μ) receptor agonist
Analgesic, antitussive, antidiarrheal
Not anti-inflammatory
Clinical Pearls
Opioid epidemic
Scheduled/controlled
Take with bowel regimen
ADRs
Common:
Pruritus (up to 80% for morphine)
Constipation, N/V
Dizziness, HA, Lightheadedness, drowsiness/somnolence
Miosis
Urinary retention
Serious:
Respiratory depression
CNS depression
Dependence
which opioid is the most potent
fentanyl!
what are meds that are Opioid Analgesics
Duragesic (CII)
fentanyl
“fent can kill” super potent, current killer
Used for sedation and general anesthesia (“vent” ventilator)
MS Contin, Kadian, Duramorph (CII)
morphine sulfate (MS)
cont continuous (lasts 8-12 hours)
Kadian circadian rhythm 24 hour pain relief
Roxicodone, OxyContin, Oxaydo (CII)
oxycodone
contin continuous (lasts 8-12 hours)
-codone related to codeine
Ultram (CIV)
tramadol
tram wreck (not as strong as a train wreck)
Opioid Analgesic / APAP Combinations
Tylenol with codeine (CIII)
APAP with codeine
#3: 300 mg APAP, 30 mg codeine
#4: 300 mg APAP, 60 mg codeine
Percocet, Roxicet, Endocet (CII)
oxycodone with APAP
-cet acetaminophen
oxy oxygen group (breathe easier with pain relief?)
Vicodin, Norco (CII)
hydrocodone with APAP
-codin -codone related to codeine
hydro hydrogen group (relax, like floating in water?)
Other pain medications
Methadose, Dolophine (CII)
methadone
For pain or opioid use disorder (opioid analgesic)
done done using opioids or done with cancer pain
This is the method to stop using opioids
Suboxone (CIII)
buprenorphine and naloxone
For opioid use disorder (opioid partial agonist and antagonist)
Sub- sublingual, or substitute for opioids
Lidoderm Patch
lidocaine
For pain (Topical analgesic/anesthetic)
-derm topical / applied to skin
-caine anesthetic (benzocaine, cocaine)
Muscle relaxants
Flexeril
cyclobenzaprine
Improve flexibility, you can cycle and bend!
Robaxin
methocarbamol
Relaxin with Robaxin
Soma
carisoprodol
Zanaflex
tizanidine
Improve flexibility
Gablofen, Lioresal
baclofen
Similar sounds
“-fen” might imply NSAID (be careful)
what are Corticosteroids
Used for inflammatory conditions (asthma, urticaria, severe allergic reactions, gout, IBD, etc.)
“-sone” or “-solone”
Orapred, Millipred, Pediapred
prednisolone
In liquid form for pediatric patients
Deltasone
prednisone
Medrol
methylprednisolone
Dose pack: 6-5-4-3-2-1
TCAs – Tricyclic Antidepressants
what is t used for
what does it cause you to do
Used for:
Depression
Neuropathic pain
Migraine prophylaxis/prevention
Elavil
amitriptyline
Pamelor
nortriptyline
“-triptyline”
“tri” Tricyclic antidepressant
Sedating could make you dizzy, careful not to trip
SSRIs – Selective Serotonin Reuptake Inhibitor
what is it used for
Used for depression and anxiety
Celexa
citalopram
Sounds like “relax”
Lexapro
escitalopram
Celexa, but like a professional
Zoloft
sertraline
Loft lift up, lift your mood
Paxil
paroxetine
Packs ill feelings
Prozac
fluoxetine
Pro + Zac hard sounds, strong antidepressant
Careful with “-oxetine”
Atomoxetine and duloxetine are not SSRIs
SNRIs – Serotonin Norepinephrine Reuptake Inhibitor
what is it used for
Used for depression
Some also used for fibromyalgia, anxiety disorders, narcolepsy, etc.
Cymbalta
duloxetine
du- Dual action w/ serotonin and norepinephrine
Playing the cymbals makes you happy
Effexor XR
venlafaxine
Pristiq
desvenlafaxine
Newer agent, must be prestigious, pristine
Depression and Smoking Cessation
Desyrel
trazodone
Serotonin Reuptake inhibitor
Used for depression and sleep
-azodone alone only works on serotonin
Remeron
mirtazapine
Remember, only one
no real pharmacologic category, it’s just an antidepressant
Wellbutrin, Zyban
bupropion
Be well, no butts
I ban smoking
Wellbutrin TID
Wellbutrin SR BID
And Zyban
Wellbutrin XL once daily
Chantix
varenicline
My chant is “I’m very inclined to quit”
Second Generation (Atypical) Antipsychotics for Schizophrenia & Bipolar Disorder
Abilify
aripiprazole
“-prazole” but not a PPI
Improved the ability to function
Risperdal
risperidone
Risper sounds like whisper
Whispers are done
Seroquel, Seroquel XR
quetipine
Quiet the voices
Zyprexa
olanzapine
Lan land on your feet
Zap zap the voices away
Be careful with ”-pine”
also suffix for CCBs
Other Psychiatric conditions
bipolar disorder
insomnia
Lithobid
lithium
BID dosing
Also bipolar swings 2 ways
Mania
Depression
Lithium battery recharge
back to baseline
Ambien, Intermezzo
zolpidem
Z drugs for zzzz sleep
Non-benzodiazepine hypnotic
Ambient light
Set up light for sleep
Restoril
temazepam
Benzodiazepine used only for sleep
Rest = sleep
Sleep hygiene – 1st line for insomnia
Use bed for sleeping or intimacy only
Establish a regular sleep pattern
Make the bedroom comfortable
Relax before bed
Exercise regularly*
Avoid eating meals shortly before bedtime
Avoid napping
Avoid alcohol, caffeine, nicotine for at least 4-6 hours before bedtime
Do not watch the clock at night
If unable to fall asleep…
Benzodiazepines For Anxiety
MIA
MOA:
Increase GABA (inhibitory)
“-azepam” or “azolam”
Klonopin
clonazepam
Clonus stiffening and relaxing of muscles (brain)
Xanax
alprazolam
Sound like “z”
makes you relax, feel sleepy
Ativan
lorazepam
Nap at a van?
“Van down by the river?”
Valium
diazepam
Dial it back relax
V available PO and IV
Both used for seizures
Other Medications for Anxiety
BuSpar
buspirone
Take the bus to the park relaxing
Vistaril
hydroxyzine pamoate
1st generation antihistamine
Also used for pruritus (brand Atarax)
Great options if we cannot use controlled medications (All BZDs are CIV)
Patients with history of substance use disorder, alcoholism, etc.
Alzheimer’s Disease / Dementia
Aricept, Adlarity
donepezil
Acetylcholinesterase Inhibitor
keeps ACh around helps w/ learning, memory, cognition
Air cognition is suffering “airy”
-cept improve perception
Namenda, Namenda XR
memantine
NMDA Receptor Antagonist
Sounds like “Rememba”
mem memory
Stimulants for ADHD
Adderall, Adderall XR
sextroamphetamine & amphetamine
Concerta, Daytrana, Metadate, Methylin, Ritalin
methylphenidate
CDMMR
Concentrate Daily, Must Must Repeat!
Focalin, Focalin XR
dexmethylphenidate
Helps you focus
Vyvanse
lisdexamfetamine
Odd man out
“f”
Vyv
Other Medications For ADHD
Strattera
atomoxetine
Not the same as SSRIs (fluoxetine, paroxetine)
Norepinephrine Reuptake Inhibitor
Strat Straightens patients’ attention
If you’ve got moxie – you’ve got determination and character (just need focus)
Intuniv
guanfacine
Intun in tune spot on focused
-facine facing forward paying attention
Influenza and Cough
Fluzone High Dose Quadrivalent, Fluarix Quadrivalent
influenza virus vaccine
Helps to prevent (or decrease severity) of the flu
IM given annually
Tamiflu
oseltamivir
Neuraminidase Inhibitor
Osel oscillation flu moves back and forth every year
-tamivir sounds like Tamiflu
Tessalon Perles
benzonatate
Tess tuss anti-tussive
Abbreviations for Asthma and COPD
FEV1:
SABA:
LABA:
ICS:
SAMA:
LAMA:
LTRA:
What is Asthma?
Chronic inflammatory disease
Reversible
Allergen triggered inflammatory reaction
Both acute and chronic inflammation
Leads to airway remodeling and bronchial hyper-reactivity
Tightened muscles constrict airway, thickened airway wall, mucus
Asthma – Epidemiology, Risk Factors
10% of children by 5-17 years
Pediatric Disease
Diagnosis by 5 years
Most have symptom resolution by adulthood
30-40% persistent adult asthma
Environmental Risk Factors
Family Size
Tobacco Smoke in utero or infancy
Allergen exposure
Urbanization
Respiratory viral infection
Decreased exposure to childhood infectious agents
Asthma – Diagnosis
1) Assess symptoms
Wheezing
History of any of the following:
Cough, worse at night
Recurrent wheeze
Recurrent difficulty breathing
Recurrent chest tightness
Symptoms occur or worsen at night, waking the patient
Symptoms worsen with triggers
2) Confirm with spirometry testing
FEV1 (forced expiratory volume in 1 second) before and after SABA
Asthma – Treatment
intermittent
symptoms: <2 days/week
step 1 - rescue (PRN)
Mild
symptoms: 2-6 days/week
step 2 - rescue (PRN) + maintenance
moderate
symptoms: daily
step 3 - rescue (PRN) + maintenance
severe
symptoms: throughout the day
step 4-5 - rescue (PRN) + maintenance
Symptoms occur: >2 times per week
Uncontrolled
STEP UP Therapy
Symptoms occur: 0-2 times per week
Controlled
If >3 months, STEP DOWN therapy
Caution with close monitoring
What is COPD?
Airflow limitation that is not fully reversible
Chronic and progressive
Umbrella term of chronic bronchitis, emphysema, or mixed
Does not affect treatment
COPD – Epidemiology
12.1 million people in US
9 million have chronic bronchitis
3.1 million have emphysema or combination
4 leading cause of death
Only leading cause of death to increase (projected to become 3rd)
By 2020 5th highest cost burden on US Healthcare
2nd leading cause of disability
Cigarette smoke is leading cause
Currently 25% of population
COPD
Exposure
Environmental tobacco smoke
Occupational dusts and chemicals
Air pollution
Patient factors
Genetic predisposition (AAT deficiency)
Airway hyper-responsiveness
Impaired lung growth
Chronic sputum production, dyspnea, chronic cough
History of exposure
FH of COPD
> 40 years old
COPD – Treatment
Global Initiative for Chronic Obstructive Lung Disease (GOLD)
Classified into Groups A, B, C, or D
Based on symptoms, airflow limitation, exacerbation history
Asthma and COPD Medications
ICS
Pulmicort
budesonide
Pulm pulmonary
Flovent
fluticasone
“-sone”
Vent ventilate, breathe
ICS + LABA Combination
Breo
fluticasone & vilanterol
Advair
fluticasone & salmeterol
Symbicort
budesonide & formoterol
“-terol” LABA
Work symbiotically to help asthma/COPD
Asthma and COPD Medications
ProAir, Ventolin, Proventil
albuterol
SABA
Combivent
ipratroprium & albuterol
Atropine is anticholinergic (antimuscarinic)
Combination of SAMA and SABA
Spiriva
tiotropium
LAMA
Spirometry revitalized
Singulair
montelukast
LTRA
Single ingredient to help breathe air
luk leukotriene
Hormonal Products For Menopause
Estrogen
Estrace, Vagifem, Vivella dot, Alora, Climara
estradiol
Premarin
conjugated / equine estrogen
Progestin
Prometrium
progesterone
Osteoporosis med
Fosamax
alendronate
Bisphosphonate
-dronate
Combination Oral Contraceptives
All contain ethinyl estradiol & a progestin
Nuvaring
etongestrel
Vaginal ring
Aviane, Seasonique, Twirla
levonorgestrel
Transdermal, weekly
Necon, Junel, Loestrin
norethindrone
Yaz, Yasmin
drospirenone
Won’t drop the potassium
Patient-centered medical care
Transitioning away from medication-centered care
Or “task-centered care”
RPhs accepting more responsibility
Depends on RPhs ability to:
Develop trusting relationships
Engage in an open exchange of information
Involve patients in decision-making regarding treatment
Help patients reach their therapeutic goals
Pharmacist’s responsibility
Patient-care responsibilities
Medication-related morbidity and mortality
Omnibus Budget Reconciliation Act of 1990
OBRA 90
Mission statements
Patient-care responsibilities:
Communication between patient and healthcare professionals serves 2 functions:
To establish an ongoing relationship
To exchange information so that you can effective utilize the Pharmacist Patient Care Process (PPCP)
Patient-centered medical care – Five dimensions
. Practitioners must understand __________ and ________________as well as the biomedical factors that affect the patient’s illness experience
- Practitioners must understand social and __psychological as well as the biomedical factors that affect the patient’s illness experience
- “Patient as person” – providers must understand that each patient’s illness is a unique experience
- Providers and patients share power and responsibility; active dialogue and collaboration in the decision-making
- “Therapeutic alliance” – patient perceptions, mutual agreement regarding _therapeutic goals__ , a trusting relationship between patient and healthcare professionals.
- Providers must be aware that their responses to patients and their behaviors may have significant effects on patients
who ultimately makes healthcare decisions
PCP
RPh
patient
third partes
the patient
Patient-centered medical care – The pharmacist must be able to…
Understand the patient’s illness experience
Acknowledge that each patient’s experience is unique
Foster a mutually respectful relationship with patients
Establish a “therapeutic alliance” with patients to meet mutually understood goals of therapy
Develop self-awareness of personal effects on patients
Medication use process
Process begins with perception and interpretation of the problem
Identifying symptoms
Previous experiences
Cultural differences
Knowledge of the problem
Misinformation?
Health beliefs
Patient may take action
Self-care therapy
Medical/medication therapy
Complimentary medicine
Power transfers to the provider?
Patient has final say
Therapeutic monitoring – patient’s role
Meeting therapeutic goals
Self-monitoring
Obtaining information from providers
Being more assertive
Joint Commission tips
Patient-Provider communication
Unanswered questions
Misunderstandings
Therapy-related problems
Self-monitoring
Decision-making
In Healthcare, Interpersonal Communication is:
The ability of the provider to elicit
and understand patient concerns,
to explain healthcare issues,
and to engage in shared decision-making if desired
Why use interpersonal communication?
Better adherence
Improve patient outcomes
Improved QOL
Patient satisfaction
Improved mental health
Trust/relationships established with healthcare team
Interpersonal communication model
The Sender
The Message
The Receiver
Feedback
Barriers