Ion Channelopathies Flashcards

1
Q

What is CF?

A
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2
Q

What are the classes of CF gene mutation?

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3
Q

Conformational changes of CFTR chloride channel during chanel gating

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4
Q

Knockout CF mice:

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5
Q

Airway epithelial cells and CF

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6
Q

Organs affected by CF and common symptoms

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7
Q

Diagnosis of CF

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8
Q

Sweat Glands (CF)

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9
Q

Nasal Potential Difference (CF)

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10
Q

TM for CF

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11
Q

Liddles Syndrome

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12
Q

Symptoms and main cause of Liddles Syndrome

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13
Q

In liddles syndrome which channel is degraded

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14
Q

RAAS activation

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15
Q

Thompsens disease

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16
Q

Symptoms of Thomsens disease

A
17
Q

In Liddles Syndrome what defect occurs in muscles

A

Myotonia Congenita (in fainting goats/ myotonic goats)

18
Q

Long QT Syndrome

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19
Q

Delayed After Depolarisation (Long QTS)

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20
Q

Determinants Delayed after Depolarisation (LQTS)

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21
Q

Nature of DAD (LQTS) graphically

A

extra heart beat

22
Q
A
23
Q

LQTS- repolarisation of the heart

A
24
Q

Facts + Causes and TM of LQTS

A