Invasive fungal infections

Question 1

Azoles inhibit

Answer 1

biosynthesis of ergosterol in the cell membrane

Question 2

Flucytosine inhibit

Answer 2

DNA/RNA synthesis in nucleus

Question 3

Echinocandins inhibit

Answer 3

b-1,3-synthesis in the cell wall

Question 4

How do polyenes work?

Answer 4

Disrupt ergosterol in the cell membrane

Question 5

How do triazoles work?

Answer 5

Decrease ergosterol production through inhibitor of fungal cytochrome P450 enzymes

Question 6

Examples of triazoles

Answer 6

fluconazole, itraconazole, posaconazole, voriconazole

Question 7

Itraconazole contraindications

Answer 7

Simvastatin and atorvastatin

Question 8

Amphoterocin mechanism of action

Answer 8

Binds to ergosterol in fungal cell membrane and creates pores to increase permeability

Question 9

Sepsis

Answer 9

Infections with systemic manifestations

Question 10

Fungi reproduce by

Answer 10

budding or fission

Question 11

Main causative organisms of fungal infections

Answer 11

Candida spp
Aspergillus spp
Cryptococcus spp
Histoplasma capsulatum

Question 12

Types of candidiasis

Answer 12

Catheter related
Acute disseminated
Chronic disseminated
Deep organ

Question 13

Complications of candidaemia

Answer 13

Dissemination

Endopthalmitis, fungal endocarditis

Question 14

Voriconazole active against

Answer 14

Candida and Aspergillus sp

Question 15

Flucytosine is an analogue of

Answer 15

Nucleoside

Question 16

Flucytosine mechanism of action

Answer 16

Converted to 5-FU intracellularly

Bone marrow suppression