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PA20319 > Anti-virals > Flashcards

Anti-virals Flashcards

1
Q

Alpha herpesviruses

A

Herpes simplex virus type 1 (HSV-1)
Herpes simple virus type 2 (HSV-2)
Varicella-zoster virus (VZV)

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2
Q

Beta herpesviruses

A

Human herpesvirus 6 (HHV-6)
Human herpesvirus 7 (HHV-7)
Cytomegalovirus (CMV)

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3
Q

Gamma herpesviruses

A

Epstein-Barr virus (EBV)

Human herpesvirus 8 (HHV-8)

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4
Q

Virulence factors for HSV

A

gC binds complement C3b (innate immune system)

gE is Fc receptor for IgG (adaptive immune system)

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5
Q

Acyclovir (Zovirax) inhibits

A

viral synthesis of DNA

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6
Q

Acyclovir (Zovirax) is a structural analog of

A

guanosine

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7
Q

First step of phosphorylation of Acyclovir is carried out by

A

Viral thymidine kinase

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8
Q

Acyclovir mechanism of action

A

Chain terminator

Incorporated into the replicating viral DNA strand and blocking further replication

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9
Q

3 drugs used in treatment of herpes zoster

A

Acyclovir
Valacyclovir
Famiciclovir

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PA20319 (12 decks)

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