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PA20319 > Antibiotic modes of action > Flashcards

Antibiotic modes of action Flashcards

1
Q

Inhibitors of cell wall synthesis

A

b-lactams, glycoproteins, fosftomycin, cycloserine, bacitracin

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2
Q

Peptidoglycan consists of alternating

A

N-acetyl-glucosamine (NAG) and N-acetyl-muramic (NAM)

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3
Q

b-lactams

A

Monobactam, cephalosporin, carbapenem, penicillin

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4
Q

b-lactams mode of action e.g. amoxicillin

A

Bind and inhibit action of PBP - transpeptidases
Get incorporated into peptide side chain
Stimulate autolysins

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5
Q

Inhibitors acting on cell membrane

A

Polymyxins

Lipopeptides

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6
Q

Inhibitors of DNA replication: Fluoroquinolones

A

Bind to and inhibit Type II (DNA gyrase) and/or type IV topoisomerases when complexed with bacterial DNA

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7
Q

Inhibitors of protein synthesis: Aminoglycosides

A

Bind irreversibly to the A-site on 16S rRNA in 30 subunit

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PA20319 (12 decks)

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