Introduksjon til pediatrisk radiologi Flashcards
Viktige kilder?
https://radiopaedia.org/articles/respiratory-distress-syndrome?lang=us
https://blog.myesr.org/ecr-2013-focus-justifying-ct-in-paediatric-radiology/
https://www.ajronline.org/doi/pdf/10.2214/AJR.11.8082
https://pubs.rsna.org/doi/10.1148/rg.323115111
https://www.rch.org.au/clinicalguide/guideline_index/Radiology_Guidelines_Acute_indications/
Hva gjør vi?
Classic:
Neonate (first 4 weeks)
Swellling middle sternocleid muscle
Torticollis
Make good / precise / well written referrals («henvisning»).
Diagnosis:
A - Congenital / (early) developmental
B - Acquired
- Inflammatory
- Infectious
- Vascular
- Neoplastic
- Traumatic
Arguments can be made both for and against the need for imaging.
For:
Calm down and educate both parents and clinicans (the latter who havn’t seen this disorder before)
Exclude differential diagnoses (if there are any relevant)
Against:
Really no need in «classical» cases (but: can we be 100% sure if it isn’t antyhing more worriesome?)
Fibromatosis colli:
Fusiform or spindle-shaped mass within the sternocleidomastoid muscle.
Underlying muscle fibril structure is preserved
Can have increased vascularity (↑doppler)
Hva bruker man rtg. til hos barn?
Contraindications:
Few, but of course radiation risk
Foreign bodies:
Accidental or self-inflicted
Fluoroscopy
is a type of medical imaging that shows a continuous X-ray image on a monitor, much like an X-ray movie.
During a fluoroscopy procedure, an X-ray beam is passed through the body. The image is transmitted to a monitor so the movement of a body part or of an instrument or contrast agent (“X-ray dye”) through the body can be seen in detail.
Upper gastrointestinal series to examine the esophagus, stomach and small intestine, or a barium enema to examine the colon.
Hva er et “babygram”?
Very common use in: Neonates (sometimes infants/children)
Head and upper abdomen
Catheters; where is the arterial catheter?
(2 arteries and 1 vein in the umbilical cord; arteries go to both internal iliac arteries + aorta on left side)
Hva ser vi på disse bildene?
Thymus (gland)
It is relatively large in infancy (weighing 25 g at birth) reaching a maximal weight in adolescence between 12 and 19 years (35 g), and gradually involutes with age (between 20 and 60 years)with progressive fatty replacement (15 g at 60 years of age).
There can be a wide variation in size between patients.
Når bruker man UL hos barn?
Contraindications:
Air and bones
Uncooperative patients
User dependent (aka «skillz»)
Hvorfor er det så viktig å være spesifikk når man henviser pas. til radiologi?
I urge you to be precise in you’re clinical information and be specific in what you want me & other radiologist to look for, given the clinical and biochemical context:
e.g.
6 year old boy with acute stomach pain. Elevated leukocytes, CRP < 6. Appendicittis? Mesenteric lymphadenitis?
Don’t dare to ask «other pathology?» at the end of the referal. Have an opinion about you’re diagnosis. We are looking for and will tell you if we find something else that could explain the patients problems.
eFAST (extended focused assessment with sonography for trauma); Checking for pneumothorax and pleural fluid
US abdomen
We don’t routinealy check the internal organs in girls/women (than you have to refer to: US internal genitals)
Når bruker man MR hos barn?
Congenital neurological disorderes in utero (zicca – microcephaly/+++)
Headache and epilepsy
Cancer primary investigation and follow up (lymphoma, sarkoma, …)
**Contraidication:**
1. It’s a giant magnet!
2. Time dependent (even T2 haste sequences)
3. May need some kind of anesthesia (mild sedative to generel anesthesia); esp. in younger children
## Footnote
[https://www.stolav.no/behandlinger/mr-av-barn/](http://)
Når bruker man CT-diagnostikk til barn?
CT = x-ray’s big brother (ionization)
Modern CT scanners are so fast that they can scan through large sections of the body in just a few seconds, and even faster in small children. Such speed is beneficial for all patients but especially children, the elderly and critically ill, all of whom may have difficulty in remaining still, even for the brief time necessary to obtain images.
For children, the CT scanner technique will be adjusted to their size and the area of interest to reduce the radiation dose.
Hvilke nuklærmedisinske bildemodaliteter kan man bruke hos barn?
Depending on the type of nuclear medicine exam, the radiotracer is either injected into the body, swallowed or inhaled as a gas and eventually accumulates in the organ or area of the body being examined.
Radioactive emissions from the radiotracer are detected by a special camera or imaging device that produces pictures and provides molecular information.
Nuclear medicine examinations provide unique information—including details on both function and anatomic structure of the body that is often unattainable using other imaging procedures, i.e.:
- Stage cancer by determining the presence or spread of cancer in various parts of the body, evaluate response to therapy & detect the recurrence of cancer
- Evaluate for hypertension related to the kidney arteries & evaluate kidneys for infection versus scar
Hvilke typer barnemishandling forekommer?
Relatively common (in the media we read and hear often of the most fatal incidents). Esp. head injuries (most common cause of death, followed by abdominaly injuries). Underreported.
Types of Abuse:
- Neglect – (omsorgsvikt) = 75%
- Emotional, sexual or physical = 17%
Don’t see psychological and most physical injuries !!!
Infants and pre-school children are at greatest risk.
Hvordan er den radiologiske us. ved mistanke om barnemishandling?
Shaken baby, battered child and other are all terms to describe the complex of non-accidental injuries (NAI) in infants and young children as a result of abuse.
Discrepancy between history and clinical/imaging findings (severity of fractures, fracture mechanism, age of the fractures)
The radiologist can be the first to suggest the diagnosis on the basis of CT studies performed to evaluate for seizures or other neurologic symptoms or on X-rays performed for other reasons.
When we look at X-rays at the emergency department, we have to realize, that the forces needed to break a bone in an infant or young child are enormous. Any fracture in this age group indicates a major traumatic event, not just a fall from a low height.
Detection of occult non-accidental injury
The role of imaging in cases of child abuse is to identify the extent of physical injury when abuse occurs, as well as to elucidate all imaging findings that point to alternative diagnoses.
When viewed in conjunction with clinical and laboratory studies, imaging findings commonly provide support for allegations of abuse (characterisc lesions to support a diagnosis or raise suspicion).
As most conventional imaging studies performed in these settings are noninvasive and entail minimal radiation.
Hvilke radiologiske bileddiagnostikk er akt. ved mistanke om barnemishandling?
Hva er hhv. indikasjon, fordel/ulemper ved disse?
Radiographic skeletal survey is the method of choice for global skeletal imaging in cases of suspected abuse.
Whole body: Appendicular & Axial
Axial:
- Ribs (AP, lateral, left and right obliques)
- Pelvis (AP)
- Lumbosacral spine (AP and lateral)
- Cervical spine (AP and lateral)
- Skull (AP and lateral)
Appendicular
- Humeri (AP)
- Forearms (AP)
- Hands (PA)
- Femurs (AP)
- Lower legs (AP)
- Feet (AP)
All children < 2 years, where physical abuse is suspected, should have a skeletal survey done!
While skeletal surveys are crucial in providing objective evidence, it is important to remember the significance of a good clinical history.
Hvilke typer frakturer forekommer ofte hos et mishandlet barn?
Although skeletal injuries rarely pose a threat to the life of the abused child, they are often the strongest radiologic indicators of abuse (secondly most common 35-88%, 2/3 have multiple injuries).
Cutaneous injuries are the most common (bruises and contusions).
Location (highly specific – metaphyseal and posterior rib fractures)
Patterns (multiplisity)
Acute rib fractures are difficult to visualize since fractures are often incomplete and nondisplaced, and/or in an area with multiple superimposed structures.
Hence they are are the most commonly missed on skeletal surveys so it is important to include oblique views of the chest and do a follow up (2 weeks; callus formation).
Unlike adults, CPR almost never causes fractures in infants. While posterior rib fractures can occur from from CPR, they are rare. Posterior rib fractures are highly specific for abuse.
Hva er CML?
Radiologisk utredning av barnemishandling
CML – classic metaphyseal Lesions = almost pathognomic of abuse (lower extrem.); Series of microfractures in the primary spongiosa of bone, which is the most immature area of mineralized matrix in the growing metaphysis.
Most common location is the lower extremities, especially the knees.
Scapular fracture: although uncommon, it is highly specific for abuse, particularly when it occurs at the acromion.
Mechanism: Shaking an infant and stretching of deltoid muscle.
Avulsion of acromion.
There is no consensus in the literature for the precise dating of fractures. Infant’s fractures heal faster than older children and adults.
Callus in diaphyseal fractures generally forms no earlier than 5 days after a fracture, but will usually form by 14 days. Thus, fractures without visible callus may be up to 14 days old, and fractures which demonstrate a little bit of callus are at least 5 days old.
Large amounts of callus indicate that the fracture is at least 2 weeks old.
Hvor ofte forekommer CNS-skader ved barnemishandling, og hvilken bildemodalitet bruker man?
Ultrasound is way to user and patient depended and should NOT be used in the imaging investigation.
Chronic bilateral subdural hematomas and new subdural hematomas in the right frontal and posterior interhemispheric region.
The bright signal is a result of methemoglobin indicating subacute hematoma ( about one week old).
CNS injury related to non-accidental injury is a leading cause of morbidity and mortality in infants and children. Abusive head trauma, accounts for 80% of deaths from head injury.
All infants and children with suspected intracranial injury must undergo cranial CT or MRI, or both. Strategies should be directed toward the detection of all intracranial sequelae of abuse and neglect with a thorough characterization of the extent and age of the abnormalities.
The CT is readily available and rapidly performed for critically ill patients. The CT is better than MRI for evaluation of acute hemorrhage (SDH); mostly ‘crescent-shape’. Associated skull and facial fractures also can be diagnosed with appropriate bone window setting images
The MRI is the best modality to fully assess intracranial injury, including extra-axial collections, intraparenchymal hemorrhages, contusions, shear injuries, and brain swelling, or edema. Imaging should be performed with T1 and T2 weighting with proton-density or inversion-recovery sequences to differentiate cerebrospinal fluid collections from other water-containing lesions. Gradient echo sequences should be included to detect hemorrhage or mineralization not demonstrable by other MRI techniques. Because MRI may fail to detect acute subarachnoid or subdural hemorrhage, its use should be delayed for 5 to 7 days in acutely ill children. MRI of the spine is also performed in most hospitals.
Hvor ofte forekommer viscerale skader ved barnemishandling, og hvilke bildemodaliteter bruker man å detektere disse?
Retinal hemorrhage is seen in nearly all cases of infant abuse in which shaking is documented.
The overall mortality rate (visceral injuries) is 13-30% due to ‘patients and doctors delay’. It´s the second most common cause of death from abuse.
Visceral perforation or hematoma
- liver- and pancreatic laceration
- adrenal bleeding
Pancreatitis, duodenal hematomas, bowel perforation, and thoracoabdominal injury associated with rib fracture heighten the suspicion of child abuse.
In children, trauma is the leading cause of pancreatic injury.
About 1/3 of all posttraumatic pancreatitis in children is abuse-related.
The most common organs injured in accidental trauma are the spleen – liver – kidneys (in that order)!
Very seldom the panceas and bowels.
How to investigate:
1. If internal chest or abdominal injury is suspected and the patient’s condition is stable, a CT of abdomen and/or thorax with IV contrast should be performed. (Here we as clinicians and diagnosticians should have a low threshold for doing a CT examination)
Vascular injuries and injuries to the liver, spleen, pancreas, and kidneys are best demonstrated after administration of intravenous contrast material.
2. US of abdomen, usually as a follow-up.
Hvilke diff.diagnoser har man til barnemishandling?
Knees x-ray: Classical appearances of severe rickets (rakitt; Vit.D mangel), at the commonest site – the knees. Severe “cupping” and “fraying” of the femoral, tibial and fibular metaphysis with widening of the physis. Underlying subchondral sclerosis.
Chest x-ray: 1 day old child with multiple fractures after a problematic delivery.
Femur x-ray: Bowing deformity and osteopenia in the femur. Multiple dense lines in the distal femur and proximal tibia associated with dense metaphyseal bands along the cartilaginous plates related to biphosphonate therapy.
A variety of coagulopathies is associated with intracranial hemorrhage in infants, including hemophilia and hypoprothrombinemia caused by vitamin K deficiency. These disorders are suggested by the clinical history, physical findings, and laboratory tests
Osteogenesis imperfecta is a rare inherited disorder of connective tissue. Other skeletal findings in these patients are generalized osteoporosis, wormian bones, bowing and angulation of healed fractures and progressive scoliosis. In addition to fractures, suggestive findings include blue sclerae, hearing impairment, dentinogenesis imperfecta, hypermobility of the joints, bruising and short stature.Subdural hemorrhage is a rare complication of the disease.
Menkes disease is a rare X-linked genetic disorder with image similarities to non-accidental injuries. Lethal condition and affected males typically die by age 2-3 years.
Hvorfor bruker man kontrast ved bildediagnostikk?
Contrast materials are not dyes that permanently discolor internal organs. They are substances that temporarily change the way x-rays or other imaging tools interact with the body.
Following an imaging exam with contrast material, the material is absorbed by the body or eliminated through urine or bowel movements.
Hvilke typer kontrasmedier bruker man ved rtg. og CT?
Iodine-based and barium-sulfate compounds are used in x-ray and computed tomography.
When iodine-based and barium-sulfate contrast materials are present in a specific area of the body, they block or limit the ability of x-rays to pass through. As a result, blood vessels, organs and other body tissue that temporarily contain iodine-based or barium compounds change their
appearance on x-ray or CT images.
Hvilke typer kontrastmedium brukes ved MR?
Gadolinium is the key component of the contrast material most often used in magnetic resonance (MR) exams.
When this substance is present in the body, it alters the magnetic properties of
nearby water molecules, which enhances the quality of MR images.
Hvilke typer kontrast kan man bruke ved UL-us.?
Microbubble contrast materials are tiny bubbles of an injectable gas held in a supporting shell. They are extremely small —smaller than a red blood cell— and have a high degree of “echogenicity”, or ability to
reflect ultrasound waves. Structures with higher echogenicity will appear brighter on ultrasound.
Only approved for clinical use in children under age of 18 years in Europe for examination of vesicoureteral reflux (VUR).
Hvorfor er det så viktig å vite om kontrastmidler?
Contrast materials are safe drugs; adverse reactions ranging from mild to severe do occur but severe reactions are very uncommon.
Treatment: Reassurance
Prevention strategy: None
Side effects and adverse and allergic reactions
Patients with impaired kidney (renal) function should be given special consideration before receiving iodine-based contrast materials by vein or artery. Such patients are at risk for developing contrast-induced
nephropathy, in which the pre-existing kidney damage is worsened
Nephrogenic systemic fibrosis (NSF), a thickening of the skin, organs and other tissues, is a rare complication in patients with kidney disease that undergo an MR with contrast materials.
Hva viser bildene?
MRI abdomen by age 1 ½ years (large expansion in the left kidney)
US and MRI by age 4 ½ years (large expansion centrally located in right kidney, growth affecting renal pelvis)
Wilms tumor, also called nephroblastoma, isa malignant (cancerous) tumor originating in the cells of the kidney. It is the most common type of renal (kidney) cancer and accounts for about 7% of all childhood cancers.
They typically occur in early childhood (1-11 years) with peak incidence between 3 and 4 years of age. Approximately 80% of these tumors are found before the age of 5 years
Hva er det alltid snakk om når det kommer til bildediagnostikk og pas.?
Spesielt yngre pas. og barn
Nytte vs. risiko!
A substantial fraction of radiologic examinations (over 30%) are of questionable merit and may not provide a net benefit to patient health care; unnecessary procedures.
Hva er stråling?
The relevant biological effect of x-rays and gamma rays is secondary to ionization.
Ionization of water molecules can create hydroxyl radicals that may interact with DNA to cause strand breaks or base damage; DNA can also be ionized directly. Although most radiation-induced damage is rapidly repaired, misrepair can lead to point mutations, chromosome translocations, and gene fusions that are linked to cancer induction.
This effect is typically thought to be stochastic, ie, it can occur at any level of radiation exposure, with the likelihood increasing as the dose increases.
The typical lag period between radiation exposure and cancer diagnosis is at least 5 years, and in most cases, the lag period may be 1 or 2 decades or longer.
Life-long cumulative effect in children.
Hvordan måler man stråling?
Bq = unit of radioactivity. One bequerel is defined as the activity of a quantity of radioactive material in which one nucleus decays per second.
Gy = quantifies the energy deposited per unit mass
Because not all types of radiation produce the same biological effect, the dose equivalent is often used instead of the absorbed dose
The dose equivalent is the product of the absorbed dose and a radiation weighting factor and is expressed in sieverts (Sv).
Because the radiation weighting factor for x-rays and gamma rays is 1.0, 1 Gy is equivalent to 1 Sv in medical imaging.
Radiation doses in medical imaging are typically expressed as millisieverts (mSv).
For reference, the average yearly background radiation dose (primarily from radon gas in the home) is around 4,5 mSv.
Radiation-induced risk is more controversial at doses between 10 and 100 mSv, the dose range relevant to medical imaging and in particular CT.
A single CT of the abdomen may have a dose of around 10 mSv, and patients who undergo multiple CTs or a single multiphasic CT fall into this dose range.
Nuclear cardiology examinations also typically fall in this dose range.
Hva er “bakgrunnstråling”?
50%-33% is coming from radon (percent wise declining).
12,5%-50% is coming from medical imaging (increasing world wide of the last decade)
Medical radiation currently accounts for an increasing percentage (approximately 50%) of the total radiation exposure for the US population (previously about 15%).
Hvilke grupper i populasjonen er mer sensitiv for ioniserende stråling?
Children are 2–3 times more sensitive to radiation than adults. And they have a longer life expactancy.
There are no data that prove a direct link between low-level radiation from diagnostic imaging and cancer.
The best data regarding long-term effects of low-level radiation (100–150mSv) exposure come from the longitudinal survivor study (LSS) of atomic bomb survivors .
The lifetime risk of fatal cancer from a single (relatively high dose) CT in a child has been estimated to be 1:1000