intro to the endocrine system Flashcards
hormones types
peptides/proteins
Amines/AAs
Steroid hormones
Amines/AAs
derivatives of tyrosine
Gives rise to thyroid hormones (thyroxine, triiodothyrine) and adrenaline and noradrenaline (catecholamines- derived from tyrosine)
Indoleamines derived from tyrptophan (melatonin)
Thyroid hormones
bind to nuclear receptors and regulate gene transcription
What types of receptors do adrenaline and noradrenaline bind to
GPCR
alpha and beta
Peptides/proteins
eg insulin
Receptor tyrosine kinase
Activates intracellular signalling via phosphorylation cascade
Steroid hormones
eg sex hormones, glucorticoids, adrenal hormones
Activate nuclear receptors - work as TFs regulating gene transcription
2 endocrine glands
Parathyroid (PTH)
- stimulated by Ca
Pancreas (insulin and glucagon)
-stimulated by glucose
medulla
adrenaline, noradrenaline
Thyroid
Thyroxine (T4)
Triodothyronine (T3)
endocrine glands
ductless
extensive blood supply
may be primary glands eg pituitary, thyroid, adrenals
Other organs may have secondary endocrine function eg brain (hypothalamus), heart, kidney
intracrine
within cell signalling
autocrine
cell releases signal that acts back on the cell
paracrine
affects neighbouring cells
endocrine
releases into circulation, affects distant target cells
Neuroendocrine
modified nerve cells that secrete directly into blood and travel to distant target cells
endocrine organs release hormones important in
reproduction, growth and development, maintenance of internal environment, regulation of energy
Hormones
produced by glands and released directly into circulation
Present in low conc
Bind to specific, high affinity recog sites or receptors on/in target cells
Single hormone may have different tissue-specific effects
Adrenal catecholamine synthesis
Tyrosine (tyrosine hydroxylase) L-DOPA ( dopa decarboxylase) Dopamine (Dopamine Beta hydroxylase) Noradrenaline (phenylethanolamine N-methyl transferase) Adrenaline
Thyroid hormone synthesis
in thyroid gland
requires iodine and tyrosine
Add 1 iodine- forms mono-iodotyrosine (MIT)
Add 2 - di-iodotyrosine (DIT)
steroid hormones produced by
adrenal gland
steroid hormone synthesis
hormone producing cells stimulated by by binding of anterior pituitary gland hormone to its plasma membrane receptor
These receptors link to Gs proteins, which activate adenylyl cyclase and cAMP production. Activates protein kinase A (cAMP) which results in phosphorylation of numerous intracellular proteins- these convert cholesterol into final steroid hormone
Steroids lipophilic
means they do well in hydrophobic environments so can cross CSMs
Peptides examples
Short AA chains eg ADH, Oxytocin
Polypeptides eg Insulin, Prolactin
Proteins example
Thyroid Stimulating hormone
Follicle “ “
Growth hormone
Peptide and protein hormones synthesis
Synthesised on ribsosomes, Packaged into secretory vesicles from the golgi as a prohormone and prohormone cleaved into active hormone
Release by exocytosis into bloodstream
up/down regulation
number of receptors for a hormone can incr or decr
cell surface receptors
GPCRs eg adrenaline
and RTKs eg insulin
Activate intracellular signalling cascades
Intracellular receptors
activate gene transcription
eg corticosteroids
Attach to a carrier protein in the blood
Carrier proteins
Bind lipophilic molecules in the blood
2 models to hormone release
- stimulus provokes hormone release from endocrine cells which acts on target cells to produce response
- Stimulus acts on hypothalamic neurone which releases regulatory hormone. Stimulates endocrine cells anterior pituitary to release another hormone, stimulates target endocrine organ to releasea hormone which activates target cells and leads to a response
endocrine communication
messages via circulation
slow transfer of info, long lasting
All cells contacted, but specificity conferred by receptors
Slow maintenance of cellular homeostasis
Positive and negative feedback loops
Contribute to circadian rhythm
endocrine disorders
hyposecretion, hypersecretion, hypo responsive (produce hormone but don’t respond to it) , hyper responsive
steroid hormones produced by
adrenal cortex and gonads
all steroid hormones are derived from
cholesterol
once they are synthesised steroid hormones
diffuse into the circulation across Plasma membrane, because lipophilic
which hormones are water soluble
most peptide and all catecholamine - transported in dissolved plasma
How are steroid and thyroid hormones transported
bound to plasma proteins