Intro To Neurone

Question 1

Which currents inactivate?

Answer 1

I Na, I A, I t

Question 2

How does mitral cell affect granule cells?

Answer 2

Excites to form long lasting IPSP

Question 3

Which transmitter does mitral cell release?

Answer 3

Glutamate

Question 4

Which transmitter reduces mitral cell inhibition during mating?

Answer 4

NA

Question 5

Where is synaptobrevin found?

Answer 5

V snare

Question 6

Where are syntaxin and snap-25 found?

Answer 6

T snare

Question 7

Where is synaptotagmin found?

Answer 7

On the vesicle

Question 8

Which transmitter is only ionotropic?

Answer 8

Glycine

Question 9

What is the major CNS excitatory transmitter?

Answer 9

Glutamate

Question 10

What are the inhibitory transmitters?

Answer 10

Gaba and glycine

Question 11

What shape are excitatory vesicles under the microscope?

Answer 11

Round

Question 12

What shape are inhibitory vesicles under the microscope?

Answer 12

Flat

Question 13

Where are inhibitory synapses found?

Answer 13

The soma

Question 14

Where are excitatory synapses found?

Answer 14

Spine or shaft

Question 15

Which channels reduce AP height?

Answer 15

K and Cl

Question 16

What is neonatal Cl- conduction like?

Answer 16

Flows OUT, raised intracellularly

Question 17

Which are the long receptors?

Answer 17

Touch, pain, olfaction

Question 18

Which are the short receptors?

Answer 18

Taste, auditory, vision

Question 19

Which synapses mediate presynaptic inhibition?

Answer 19

Axoaxonic

Question 20

Which kind of depolarisation does the axoaxonic synapse produce?

Answer 20

Primary afferent

Question 21

Which currents are inwardly rectifying?

Answer 21

K1, K-ACh, KATP

Question 22

Which currents are delayed recitfiers?

Answer 22

Kv11.1, Kv1.5, KCNE1/KvLQT2

Question 23

Where do basal dendrites come from?

Answer 23

The soma

Question 24

What are internal chloride and calcium like?

Answer 24

Low

Question 25

What extrudes chloride?

Answer 25

NCKX and NCX

Question 26

What are the non-NMDA receptors?

Answer 26

AMPA and kariate

Question 27

What are NMDA receptors like?

Answer 27

Don’t obey Ohm’s law, slower decay of the response

Question 28

What does PLA form via Gi?

Answer 28

Arachidonic acid

Question 29

How does NO cause cGMP production?

Answer 29

Acts on sGC

Question 30

Which afferents and motor neurones do muscle spindles act on?

Answer 30

IA afferent, alpha-MN

Question 31

How many IA afferents are needed to make alpha-MN fire?

Answer 31

Many - EPSP below threshold

Question 32

What happens to ionotropic Glu-R at 0mV?

Answer 32

Changes direction

Question 33

How do muscle spindles inhibit antagonists?

Answer 33

Interneurone releasing glycine

Question 34

What happens to time to AP peak as dendrites approach cell body?

Answer 34

Slower - more capacitance to charge

Question 35

What happens to K+ permeability with some IPSPs?

Answer 35

Increased

Question 36

What current is needed for a graded potential?

Answer 36

A current

Question 37

What is the A current?

Answer 37

Further K+ conductance which does inactivate to space out spikes

Question 38

What inactivates transient Ca2+ channels?

Answer 38

Steady depolarisation

Question 39

Which currents do thalamic relay neurones use?

Answer 39

Ih

Question 40

What activates the Ih current?

Answer 40

Hyperpolarisation

Question 41

What does Ca2+-activated K+ conductance do to spiking?

Answer 41

Slows and terminates bursts

Question 42

What happens to olfactory receptor nuerones when exposed to prolonged stimuli?

Answer 42

Coupled oscillation of Ca2+ and cAMP

Question 43

Why do olfactory receptor neurones oscillate?

Answer 43

Preserves ability to fire spikes

Question 44

What is it called when subliminal fringe cells can’t be stimulated twice?

Answer 44

Response occlusion

Question 45

In which area of the hypothalamus do commisural fibres make spatially-segregated synapses on pyramidal cell dendrites?

Answer 45

CA1