Intro Flashcards

1
Q

What is immunology?

A

The study of the immune system

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2
Q

Pathology

A

The study of the causes/effects of diseases

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3
Q

Why immunology and pathology are important?

A

To make the correct diagnosis
To give the correct treatment
To understand systemic diseases
To make appropriate referrals
To advise and educate patients

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4
Q

What is aetiology?

A

The cause, set of causes, or manner of causation of a disease or condition.

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5
Q

What is morphology?

A

The phenotypic changes associated with a disease.

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6
Q

What is pathogenesis?

A

Progressive changes as disease develops

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7
Q

What is sequalae?

A

What happens next? Can involve intervention

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8
Q

What are the diseases that linked with periodontitis?

A

Diabetes
Rheumatoid Arthritis
Stroke
Alzheimer’s Disease

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9
Q

Surgical Sieve

A

Differential diagnosis in which the clinician must distinguish symptoms of a particular disease or condition from others that present similar clinical features

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10
Q

Mention the organs of the immune system

A

Thymus
Lymph nodes
Bone marrow
Spleen

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11
Q

Where is the thymus located?

A

Behind the breastbone

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12
Q

Where does the T-cells mature?

A

In the thymus

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13
Q

What is the function of lymph nodes?

A

Produce and store cells that fight infection and disease.

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14
Q

What will happen to the lymph nodes when someone get infection?

A

Lymph nodes can get larger and feel sore.

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15
Q

What is the largest lymphatic organ?

A

Spleen

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16
Q

What is the system that connect the 4 main organs of the immune system?

A

Lymphatic system

17
Q

What are the function of the lymphatic system?

A

-Transport clean fluids back to the blood
-Drains excess fluids from tissues
-Removes “debris” from cells of body
-Transports fats from digestive system

18
Q

What are the 2 branches of the immune system?

A

Innate immunity
Adaptive immunity

19
Q

Innate immunity

A

Non-specific/ effective/ fast first line defence (1-4 days)
Regular contact with pathogens which are destroyed within minutes or hours, only rarely causing disease

  • Examples:
    1-Epithelium (skin): physical barrier
    2-Innate cell subsets & complement: Macrophages, neutrophils, dendritic cells
    3-Chemokines/cytokines: cell recruitment, activation and proliferation
20
Q

Adaptive immunity

A

Specific/long lived second line defence (4-10 days)
Repeat infections met immediately with strong/specific respons

  • Examples
    1-B cell (Humoral) → Antibody production
    2-T cells (Cell-mediated) → Cell-cell communication (Various types)
21
Q

What is inflammation and what is aimed to?

A

“to set on fire”
Aimed at eliminating inciting cause:
• invading microorganisms
• particulate materials e.g. dust\ prostheses e.g. denture material
• altered self cells
• transformed malignant cells (cancer)

22
Q

Stages of inflammation

A

1) Initiation - Response to harmful stimuli
2) Progression - Containment of harmful stimuli
3) Amplification - Modulation of immune response
4) Resolution - Healing (Acute inflammation)\ Failure to resolve - (Chronic inflammation)