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Pathology & Immunity > Defence Cells > Flashcards

Defence Cells Flashcards

1
Q

Innate immune defence cells

A

Mast cells
Monocytes/Macrophages
Natural Killer cells (NK cells)
Dendritic cells
Neutrophils
Eosinophils and Basophils
Innate immune cells (ILCs)

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2
Q

Upon migration into tissues, monocyte differentiates into?

A

Macrophages

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3
Q

What are the function of Monocytes/Macrophages?

A

Phagocytoses → antigen presentation
Cytokine release → Immune cell recruitment

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4
Q

What innate immune defence cells best known for role in allergy?

A

Mast cells

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5
Q

What are the function of mast cells?

A

Release of active agents and histamines
Important in immune response to parasitic worms

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6
Q

What is the most numerous/important cells in innate immune responses?

A

Neutrophils

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7
Q

What innate immune defence cells phagocytic granulocytes?

A

Neutrophils
Eosinophils
Basophils

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8
Q

What are the functions of Neutrophils?

A
  • Utilise Neutrophil Extracellular Traps (NETs)
  • Phagocytosis & degranulation
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9
Q

What are the functions of Basophils & Eosinophils?

A

Contribute to allergen response
Eosinophils - defense against parasites

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10
Q

What of innate immune defense cells that recognize and kill abnormal cells/tumours/viral infected cells by releasing lytic granules ?

A

Natural Killer (NK) cells

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11
Q

What type of innate immune defense cells are non-cytotoxic members of the NK cell family?

A

Innate lymphoid cells (ILCs)

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12
Q

Name the cells that activate T and B cells?

A

Dendritic cells

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13
Q

Explain the antigen presentation function of dendritic cells?

A

Antigen presentation:
Migrate from blood → target tissue → Phagocytosis of virulent organism

Possess finger like processes, presenting exogenous antigen via MHC I and T cell receptors to naive T cell

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14
Q

What cells formed the bridge between innate and adaptive immune responses?

A

Dendritic cells

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15
Q

Innate immune cells (cells of myeloid origin)

A
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16
Q

Innate immune cells (cells of myeloid or lymphoid origin)

A
17
Q

Adaptive immune cells (cells of lymphoid origin)

A
18
Q

T cell give rise to

A

Cellular immunity: the immune response that involves the activation of T cells to defend against intracellular pathogens.

19
Q

Subset of T cells

A

• T helper cells (CD4+): function to help support other
immune cells to fight threats
-Can be TH1, TH2, TH17, TFH cells

• Cytotoxic T cells (CD8+): destroy our own cells which
have become infected (usually virus-related)

• Regulatory T cells (Tregs): regulate or suppress other cells in the immune system

20
Q

How T cells recognize forigen antigen?

A

T Cell Receptor (TCR)

21
Q

B cells function

A
  • Antibody production: Plasma cells
  • Memory generation: Memory B cells

Pathology & Immunity (13 decks)

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