Defence Cells Flashcards
Innate immune defence cells
Mast cells
Monocytes/Macrophages
Natural Killer cells (NK cells)
Dendritic cells
Neutrophils
Eosinophils and Basophils
Innate immune cells (ILCs)
Upon migration into tissues, monocyte differentiates into?
Macrophages
What are the function of Monocytes/Macrophages?
Phagocytoses → antigen presentation
Cytokine release → Immune cell recruitment
What innate immune defence cells best known for role in allergy?
Mast cells
What are the function of mast cells?
Release of active agents and histamines
Important in immune response to parasitic worms
What is the most numerous/important cells in innate immune responses?
Neutrophils
What innate immune defence cells phagocytic granulocytes?
Neutrophils
Eosinophils
Basophils
What are the functions of Neutrophils?
- Utilise Neutrophil Extracellular Traps (NETs)
- Phagocytosis & degranulation
What are the functions of Basophils & Eosinophils?
Contribute to allergen response
Eosinophils - defense against parasites
What of innate immune defense cells that recognize and kill abnormal cells/tumours/viral infected cells by releasing lytic granules ?
Natural Killer (NK) cells
What type of innate immune defense cells are non-cytotoxic members of the NK cell family?
Innate lymphoid cells (ILCs)
Name the cells that activate T and B cells?
Dendritic cells
Explain the antigen presentation function of dendritic cells?
Antigen presentation:
Migrate from blood → target tissue → Phagocytosis of virulent organism
Possess finger like processes, presenting exogenous antigen via MHC I and T cell receptors to naive T cell
What cells formed the bridge between innate and adaptive immune responses?
Dendritic cells
Innate immune cells (cells of myeloid origin)
Innate immune cells (cells of myeloid or lymphoid origin)
Adaptive immune cells (cells of lymphoid origin)
