Intro Flashcards
Urine composition
95% water
5% solutes
Organic components of urine
Urea
Creatinine
Major organinc component of urine
Urea ( 60% - 90%)
Inorganic components of urine
Chloride
Sodium
Potassium
[ChaNaK]
Major inorganic component of urine
Chloride
Recommended capacity of container for urine spx
50 mL
Sterile containers are suggested if _______ elapse between spc collection and analysis
> 2 hours
Reasons for spx rejection
Unlabeled container
Non matching labels
Contaminated spx
Insufficient quantity
Improper transport
After collection, spx must be sent to the lab and tested within_____
2hours
Analytes that increases if spx is not properly preserved
pH
Bacteria
Odor
Nitrite
[PaBaON]
It is the most routinely use method of physical preservative
Refrigeration
Temp of refrigerator used as preservative
2-8 celsius
T or F:
Refrigeration increases sg when measured by urinometer
True
Ideal preservatives
Chemical
Preservative that preserves glucose and sediment well
Thymol
Preservative that preserves protein and fprmed elements well
Boric acid
Excellent sediment preservative
Formalin
Good preservative for drig analysis
Sodium fluoride
Most commonly received spx
Random
Random urine spx is useful for
Routine screening test
Ideal screening spx
8 hour spx (first morning)
8 hour spx is useful for
Preventing false negative pregnancy test and evaluating orthostatic proteinuria
Fasting spx is useful
for glucose monitoring
Spx used for monitoring insulin therapy
2-hour post prandial
Spx used to test glucose and ketones
Glucose tolerance spx
Early afternoon spx is useful for
Urobilinogen determination
12- hour urine is for
Addis count
Catheterized spx is used to
Measure function of individual kidney
Most common used for bacterial culture
Catheterized spx
Spx used as an alternative to catheterized spx
Midstream clean catch
Suprapubic aspiration is used for
Cytologic examination
Volume used for drug spx collection
30-45 mL
Temp and time used for drug spx collection
32.5 to 37.7 Celsius for 4 mins
Normal daily urine output
600-2000 mL
Average urine output
1200-1500 mL
Decreased urine output
Oliguria
Oliguria in infants
< 1mL/kg/ hr
Oliguria in children
< 0.5 mL/ kg/ hr
Oliguria in adult
< 400 mL/ day
Anuria means
Cessation of urine flow
T or F:
The kidney excrete 2-3 times more during night than day
False ( more during day than night)
Increased nocturnal excretion
Nocturia
Increased DAILY urine
Polyuria
Polyuria in children
2.5 to 3 ml/kg/day
Polyuria in adult
> 2.5 L/day
Difference between DI and DM
DI
- decreased SG
- problem is in the ADH
DM
- increases SG
- problem is in the insulin
Color of urine is mainly determined by its_______
Concentration
Pale yellow urine means
Dilute
Dark yello urine means
Concentrated
It causes yello pigment in urine
Urochrome
Who named urochrome
Thudichum (1864)
T or F:
Production of urochrome is dependent on the body’s metabolic state
True
It causes PINK pigment that results amorphous urates precipatation
Uroerythrin
It causes ORANGE-BROWN pigment in the oxidation product of urobilinogen
Urobilin
How to examine urine color
Examine under good light source against white bg
It produces YELLOW FOAM when shaken
Bilirubin
_______ also produces yellow foam when shaken that can be mistaken for bilirubin
Phenazopyridine
It produces RED and CLOUDY urine
Rbc
It produces RED and CLEAR urine
Hgb and myoglobin
When does red urine becomes brown
When the RBC remains in an acidic urine for serveral hours due to oxidation of hgb to methgb
Hgb is the result from
In vivo breakdown of RBC
Myoglobin is the result from
Breakdown of skeletal muscle
It causes PORT WINE color urine due to oxidation of porphobilinogen
Porphyrin
Pigmented food that produces red color in ALKALINE urine
Beets
Pigmented food that produces red color in ACIDIC urine
blackberries
Metabolite of phenylalanine
Homogentisic acid
Homogentisic acid imparts a black color to ALKALINE urine in px with ______
Alkaptonuria
Bacterial infxn imparts what color of urine
Green
It refers to the transparency or turbidity of urine spx
Clarity
No visible particulates
Transparent
Clear
Few particulares
Prints easily seen thru urine
Hazy
MANY particulates
Prints blurred thru urine
Cloudy
Prints CANNON be seen thru urine
Turbid
May precipitate or be clotted
Milky
How to report clarity
Clear
Hazy
Cloudy
Turbid
Milky
[CHeck-Co- kung- TaMa]
Nonpathologic turbidity
Squamous epithelial
Bacteria
Amorphous urates, phosphate and carbonates
Semen
Fecal contamination
Radiographic contrast media
Talcum powder
Vaginal cream
Pathological turbidity
Rbc, Wbc, bacteria, or yeast cell
Abnormal amounts of nonsquamous cell
Abnormal crystals
Lumph fluid
Lipids
Indicator of concentration of dissolved material in the urine
specific gravity
First fxn to diminish in renal dsx
Tubular reabsorption
Normal urine SG
Random: 1.003-1.035
24-hour: 1.015-1.025
Sg of Isosthenuria urine
1.010
It is the end stage of renal dsx
Isosthenuria
Direct method for determining sg
Urinometer and harmonic oscillation densitometry
Principle: density (both)
Indirect method for determining sg
Refractometer and Reagent strip
How many volume are needed for urinometer
10-15 mL
Urinometer is usually calibrated at
20 celsius
The frequency or sound waves entering a solution
HOD( harmonic oscillation densitometry)
HOD result is valid up to sg of
1.080
Volume of urine needed for Refractometer
1-2 gtts
Refractometer is calibrated between
15-38 celsius
Calibration needed for Refractometer
Distilled water- 1.000
5% NaCl- 1.022
9% Sucrose- 1.034
Lack of odor in urine from px with ARF suggest
Acute tubular necrosis
Normal odor of urine
Aromatic
Odor of urine when there is a BACTERIAL decomposition
Foul and ammonia-like
Presence of KETONE suggest what odor
Fruity and sweet
Px with PHENYLKETONURIA has the _______ odor of urine
Mousy
Tyrosinemia
Rancid
Isovaleric acidemia and glutaric acidemia
Sweaty feet
Methionine malabsorption
Cabbage and hops
Trimethylaminuria
Rotting fish