Intracellular Signalling Mechanisms Flashcards
1
Q
The phospholipid bilayer facilitates movement of what: 1) water soluble or 2) lipid soluble compounds?
A
Lipid soluble compounds
2
Q
How do steroid hormones influence signalling?
A
Diffusion across the membrane, and associating with a cytosolic receptor, diffusing into the nucleus and binding to response elements to influence gene transcription
3
Q
What are the two broad classes of kinases?
A
Ser / Thr kinases
Tyr kinases
4
Q
What do kinases do?
A
Phosphorylate
5
Q
What do phosphatases do?
A
Dephosphorylate
6
Q
Describe the structure of GPCRs
A
7 Transmembrane domain proteins, coupled to either Gi, Gq, Gs
7
Q
What are the two types of Acetylcholine receptor? How are they different?
A
Nicotinic receptor (Ion channel receptor)
Muscarinic receptor (GPCR receptor)
