How Drugs Act II Flashcards
1
Q
What are the four components of Pharmacokinetics?
A
A - Absorption
D - Distribution
M - Metabolism
E - Excretion
2
Q
Describe Phase 1 Metabolism
A
Utilises Cytochome P450
3
Q
The electrons used for Cytochrome P450 is sourced from where?
A
NADPH-CYP450 Reductase
4
Q
Describe the three ways Phase 2 Metabolism can occur
A
- Glucuronidation
Most common reaction, occurs in the liver microsomal enzyme system. Makes drugs more soluble and easily excreted into urine - Amino acid Conjugation
Addition of Glycine or Glutamine - Sulfoconjugation
5
Q
What is elimination half life?
A
The time it takes for plasma concentration of a drug to fall by 50%
