Intracellualr signalling pathway effector mechaism

Question 1

Effectors can be enzymes give two examples

Answer 1

adenylyy cyclase ATP->cAMP

phospholipase C PIP2->IP3+DAG

Question 2

Effectors Can be ion channels give an example

Answer 2

Voltage operated calcium channels (VOCC)

Question 3

Agnes stimulates regulation of the adenylyl cyclase name the specific G-protein in the receptor

Answer 3

GS

beta- adrenoceptor

Question 4

GI subunit can interact with what receptors

Answer 4

Alpha-2- adrenoceptor

mu-opioid receptor

Question 5

Cycle MP acts on

Answer 5

PKA

Question 6

Name the domains of PKA

Answer 6

Two regulatory domains bound to catalytic domains

Question 7

GQ G proteins associate with which receptors

Answer 7

Alpha-1 Adrenoceptor

M1 - muscarinic receptor

Question 8

Signal amplification

Answer 8

Activation of adenylyl cyclase generates many molecules of cycling MP which then activate many PKA

Question 9

Inotrophy in the heart caused by what

Answer 9

Adrenaline and your adrenaline can interact with beta one and adrenoceptor to increase force of contraction

VOCC phosphorylated allows more calcium into cell

Question 10

PIP2 splits into

Answer 10

IP3 and DAG

Question 11

DAG activates

Answer 11

PKC

Question 12

IP3 activates

Answer 12

IP3 receptor on SER membrane

Question 13

Morphine what receptor and what do proteins interact with

Answer 13

MU-opioid receptor

G alpha i