Autonomic nervous system Flashcards
Three divisions of the autonomic nervous system
Sympathetic
parasympathetic
enteric
What are the five divisions of the spinal column
Medullary cranial thoracic Lumbar sacral
Describe the relative lengths and minor nations of the two neurons in the parasympathetic system
Long myelinated pre-ganglion
short unmyelinated post ganglion
In parasympathetic system first gangly and is found where
Within the innervated tissue
Parasympathetic Anglian one ganglion to what type of receptors
Ganglion one as a cholinergic
acetyl-choline binds to the nicotinic acetyl choline receptor
Ganglion to is cholinergic
acetyl-choline binds to the muscarinic acetyl choline receptor
Muscarinic ACh receptor is what kind of receptor
G-protein
M2 receptor leads to of the parasympathetic nervous system
Bradycardia
Explain the relative lengths of the pre-and post embryonic neurons in the sympathetic nervous system
Short myelinated
alone unmyelinated
What kind of receptors are involved in the sympathetic nervous system
Androgenic receptors
alpha-1 alpha-2 beta one beta two
First ganglion of the parasympathetic system is what kind of receptor
Cholinergic, acetylcholine binds to nicotinic acetyl choline receptor
Post ganglia nerve is what kind of receptor
Binds noradrenaline to Katrina receptors
Post ganglia nerve is what kind of receptor symapthetic
Binds noradrenaline to adreno receptors
Explain sweat gland
Sweat gland sympathetic
instead of having typical noradrenaline binding to adreno receptor
have acetal choline binding to muscarinic ACh receptor
Adrenal glands
Nerve initiates in the Chromaffin cells
stimulates and ACh nicotinic receptor
which then releases the hormone adrenaline
How can we follow logically intervene with the automatic nervous system activity
Degradation of transmitter interaction with postsynaptic receptors inactivation of transmitter reuptake of transmitter interaction with presynaptic receptor
ACh synthesis requires what enzyme
Choline acetyl transferase CAT
Ach degradation requires were enzyme
acetyl choline esterase
Nicotinic ACh receptors at the automatic ganglia and the neuromuscular junction different structure this can be useful
See activity of drug design
Specific drug used to target the muscarinic Ach antagonist is
Tolteradine-useful overactive bladder
Issues with devising drugs automatic nervous system
Relative lack of selectivity of cholinergic drugs means unwanted side effects
Sludge is caused by massive discharge of the parasympathetic nervous system what could cause this
Drug overdose
Magic mushrooms
organophosphorus insecticides- Caerphilly modified is acetly cholineester
Sludge
Saliva
lacrimation urination desiccation GI upset emesis
mAch Agnes example
Bethanechol used to stimulate bladder emptying
post ganglionic sympathetic neurons posses highly branched axonal network called
varicosities
Neuro adrenaline vesical release requires
Calcium
precursoers of noradenralin
tyrosine
DOPA
dompamine
noradenaline
termination of noradenaline
uptake 1 on pre synapic membrane
uptake 2 on post synapic membrane
NA which is to put into vesicales in the synapic membrane what happeens to
two enzymes act on COMT MAO
agonist of B2 receptors
salbutamol used in asthma for bronchoconstricion
