ATP dependent pumps and ion exchnagers

Question 1

Secondary active transport

Answer 1

Uses gradients made by primary active transport

Question 2

Sodium potassium ATPase

Answer 2

Pumps 3 sodium out of cell
two potassium into cell

Drive secondary active transport

Question 3

Control of resting calcium levels

Answer 3

Primary active transport
PMCA
SERCA

Secondary active transport
NCX

Facilitated transport
mitochondrial calcium uni ports

Question 4

P MCA affinity and capacity

Answer 4

HiGH Affinity low capacity

Question 5

NCX ability and capacity

Answer 5

Low affinity high capacity

Question 6

Direction of sodium calcium exchanger

Answer 6

Flow in the direction of sodium gradient
therefore direction can change
role in expelling intracellular calcium during recovery

Question 7

Which transporter is associated with ischaemia

Answer 7

Sodium calcium exchanger.
ATP depletion means sodium potassium ATPase cannot function, therefore sodium builds up inside the cell. The sodium calcium exchanger will reverse its function and move sodium out of cell, however this brings calcium into cell. Increase in intracellular calcium levels is toxic

Question 8

Channels involved in acid extrusion

Answer 8

Sodium hydrogen exchange

sodium chlorine HCO3 hydrogen co-transporter

Question 9

Charles involved in alkaline influx

Answer 9

Sodium chlorine bicarbonate hydrogen co-transporter

sodium bicarbonate co-transporter

Question 10

Channels involved with alkaline extrusion

Answer 10

Ion exchange bicarbonate out choride in

Question 11

cell swelling causes bu

Answer 11

ion influx

Question 12

cell shrinking caused by

Answer 12

extrution of ion

Question 13

thick accending limb drugs

Answer 13

loop diuretics

Question 14

distual convoultued tuble

Answer 14

thiazide

Question 15

collecting duct

Answer 15

spironolactone